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Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children

Claudia M. Toledo-Corral; Christian K. Roberts; Gabriel Q. Shaibi; Christianne J. Lane; Paul B. Higgins; Jaimie N. Davis; Marc J. Weigensberg; Michael I. Goran (Profiled Author: Gabriel Shaibi)

Journal of Pediatric Endocrinology and Metabolism. 2008;21(9):855-864.

The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 ± 1.7 yr; body mass index: 28.2 ± 5.4 kg/m²). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, p <0.001 and r = -0.25, p <0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, p <0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, p = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children. © Freund Publishing House Ltd., London.

PMID: 18924579    

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