William R. Jacobs, Jr.

Microbiology & Immunology

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William R. Jacobs, Jr.

• Departments
  Microbiology & Immunology
  
  

718-678-1075

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This is a list of publications by this researcher, listed chronologically starting with the most recent first. New publications appear in this list weekly. The source of publications and 'cited by' data for this application is Scopus.

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• 1.

  2012

  Catherine Vilchèze; William R. Jacobs Jr.

  The combination of sulfamethoxazole, trimethoprim, and isoniazid or rifampin is bactericidal and prevents the emergence of drug resistance in Mycobacterium tuberculosis

  Antimicrobial Agents and Chemotherapy. 2012;56(10):5142-5148.
  1

• 2.

  2012

  Natalie Taylor; Faith Bahunde; Afton Thompson; Jae-Sung Yu; William R. Jacobs Jr.; Norm L. Letvin; Barton F. Haynes; Sunhee Lee

  Enhanced priming of adaptive immunity by Mycobacterium smegmatis mutants with high-level protein secretion

  Clinical and Vaccine Immunology. 2012;19(9):1416-1425.
  0

• 3.

  2012

  Kristopher Kolibab; Steven C. Derrick; William R. Jacobs; Sheldon L. Morris

  Characterization of an intracellular ATP assay for evaluating the viability of live attenuated mycobacterial vaccine preparations

  Journal of Microbiological Methods. 2012;90(3):245-249.
  0

• 4.

  2012

  Kara Jensen; Uma Devi K. Ranganathan; Koen K. A. Van Rompay; Don R. Canfield; Imran Khan; Resmi Ravindran; Paul A. Luciw; William R. Jacobs Jr.; Glenn Fennelly; Michelle H. Larsen; et al.

  A recombinant attenuated Mycobacterium tuberculosis vaccine strain is safe in immunosuppressed simian immunodeficiency virus-infected infant macaques

  Clinical and Vaccine Immunology. 2012;19(8):1170-1181.
  0

• 5.

  2012

  Hiroyuki Yamada; Apoorva Bhatt; Radostin Danev; Nagatoshi Fujiwara; Shinji Maeda; Satoshi Mitarai; Kinuyo Chikamatsu; Akio Aono; Koji Nitta; William R. Jacobs Jr.; et al.

  Non-acid-fastness in Mycobacterium tuberculosis ΔkasB mutant correlates with the cell envelope electron density

  Tuberculosis. 2012;92(4):351-357.
  1

• 6.

  2012

  Helen McShane; William R. Jacobs; Paul E. Fine; Steven G. Reed; David N. McMurray; Marcel Behr; Ann Williams; Ian M. Orme

  BCG: Myths, realities, and the need for alternative vaccine strategies

  Tuberculosis. 2012;92(3):283-288.
  3

• 7.

  2012

  Paras Jain; Travis E. Hartman; Nell Eisenberg; Max R. O'Donnell; Jordan Kriakov; Karnishree Govender; Mantha Makume; David S. Thaler; Graham F. Hatfull; A. Willem Sturm; et al.

  φ ²GFP10, a high-intensity fluorophage, enables detection and rapid drug susceptibility testing of Mycobacterium tuberculosis directly from sputum samples

  Journal of Clinical Microbiology. 2012;50(4):1362-1369.
  1

• 8.

  2012

  Rosamund Chapman; Enid Shephard; Helen Stutz; Nicola Douglass; Vasan Sambandamurthy; Irene Garcia; Bernhard Ryffel; William Jacobs; Anna-Lise Williamson

  Priming with a recombinant pantothenate auxotroph of mycobacterium bovis bcg and boosting with mva elicits HIV-1 gag specific CD8 ⁺ T cells

  PLoS ONE. 2012;7(3).
  0

• 9.

  2012

  Steven C. Derrick; Dee Dao; Amy Yang; Kris Kolibab; William R. Jacobs; Sheldon L. Morris

  Formulation of a mmaA4 gene deletion mutant of mycobacterium bovis BCG in cationic liposomes significantly enhances protection against tuberculosis

  PLoS ONE. 2012;7(3).
  0

• 10.

  2012

  Daniel E. Goldberg; Robert F. Siliciano; William R. Jacobs Jr.

  Outwitting evolution: Fighting drug-resistant TB, Malaria, and HIV

  Cell. 2012;148(6):1271-1283.
  8

• 11.

  2012

  Neema Bourai; William R. Jacobs; Sujatha Narayanan

  Deletion and overexpression studies on DacB2, a putative low molecular mass penicillin binding protein from Mycobacterium tuberculosis H ₃₇Rv

  Microbial Pathogenesis. 2012;52(2):109-116.
  1

• 12.

  2012

  Manjunatha M. Venkataswamy; Michael F. Goldberg; Andres Baena; John Chan; William R. Jacobs; Steven A. Porcelli

  In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCG

  Vaccine. 2012;30(6):1038-1049.
  1

• 13.

  2011

  Marcela Parra; Steven C. Derrick; Amy Yang; JinHua Tian; Kristopher Kolibab; Miranda Oakley; Liyanage P. Perera; William R. Jacobs; Sanjai Kumar; Sheldon L. Morris

  Malaria infections do not compromise vaccine-induced immunity against tuberculosis in mice

  PLoS ONE. 2011;6(12).
  1

• 14.

  2011

  Paras Jain; David S. Thaler; Mamoudou Maiga; Graham S. Timmins; William R. Bishai; Graham F. Hatfull; Michelle H. Larsen; William R. Jacobs

  Reporter phage and breath tests: Emerging phenotypic assays for diagnosing active tuberculosis, antibiotic resistance, and treatment efficacy

  Journal of Infectious Diseases. 2011;204(SUPPL. 4):S1142-S1150.
  3

• 15.

  2011

  Kari A. Sweeney; Dee N. Dao; Michael F. Goldberg; Tsungda Hsu; Manjunatha M. Venkataswamy; Marcela Henao-Tamayo; Diane Ordway; Rani S. Sellers; Paras Jain; Bing Chen; et al.

  A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

  Nature Medicine. 2011;17(10):1261-1268.
  28

• 16.

  2011

  Ka-Wing Wong; William R. Jacobs

  Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis

  Cellular Microbiology. 2011;13(9):1371-1384.
  13

• 17.

  2011

  Catherine Vilchèze; Yossef Av-Gay; S. Whitney Barnes; Michelle H. Larsen; John R. Walker; Richard J. Glynne; William R. Jacobs Jr.

  Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis

  Antimicrobial Agents and Chemotherapy. 2011;55(9):4422-4423.
  5

• 18.

  2011

  Halimah Sayahi; Oren Zimhony; William R. Jacobs Jr.; Alexander Shekhtman; John T. Welch

  Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase i

  Bioorganic and Medicinal Chemistry Letters. 2011;21(16):4804-4807.
  5

• 19.

  2011

  Patamaporn Pruksakorn; Masayoshi Arai; Liu Liu; Prashini Moodley; William Robert Jacobs Jr.; Motomasa Kobayashi

  Action-mechanism of trichoderin A, an anti-dormant mycobacterial aminolipopeptide from marine sponge-derived Trichoderma sp.

  Biological and Pharmaceutical Bulletin. 2011;34(8):1287-1290.
  1

• 20.

  2011

  Catherine Vilchèze; Anthony D. Baughn; JoAnn A. Tufariello; Lawrence W. Leung; Mack Kuo; Christopher F. Basler; David Alland; James C. Sacchettini; Joel S. Freundlich; William R. Jacobs Jr.

  Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions

  Antimicrobial Agents and Chemotherapy. 2011;55(8):3889-3898.
  6

• 21.

  2011

  Xia Xu; Catherine Vilchèze; Yossef Av-Gay; Anaximandro Gómez-Velasco; William R. Jacobs Jr.

  Precise null deletion mutations of the mycothiol synthesis genes reveal their role in isoniazid and ethionamide resistance in Mycobacterium smegmatis

  Antimicrobial Agents and Chemotherapy. 2011;55(7):3133-3139.
  7

• 22.

  2011

  Liliana Rondón; Mariana Piuri; William R. Jacobs Jr.; Jacobus De Waard; Graham F. Hatfull; Howard E. Takiff

  Evaluation of fluoromycobacteriophages for detecting drug resistance in Mycobacterium tuberculosis

  Journal of Clinical Microbiology. 2011;49(5):1838-1842.
  5

• 23.

  2011

  Rafael Prados-Rosales; Andres Baena; Luis R. Martinez; Jose Luque-Garcia; Rainer Kalscheuer; Usha Veeraraghavan; Carmen Camara; Joshua D. Nosanchuk; Gurdyal S. Besra; Bing Chen; et al.

  Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice

  Journal of Clinical Investigation. 2011;121(4):1471-1483.
  16

• 24.

  2011

  Jae-Sung Yu; John Whitesides; Sun-Hee Lee; Natalie Taylor; William R. Jacobs Jr.; Norman L. Letvin; Barton F. Haynes

  Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression

  Clinical and Vaccine Immunology. 2011;18(1):43-49.
  2

• 25.

  2011

  Joseph Hinchey; Bo Y. Jeon; Holly Alley; Bing Chen; Michael Goldberg; Steven Derrick; Sheldon Morris; William R. Jacobs Jr.; Steven A. Porcelli; Sunhee Lee

  Lysine auxotrophy combined with deletion of the secA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis

  PLoS ONE. 2011;6(1).
  9

• 26.

  2011

  Welkin H. Pope; Christina M. Ferreira; Deborah Jacobs-Sera; Robert C. Benjamin; Ariangela J. Davis; Randall J. DeJong; Sarah C. R. Elgin; Forrest R. Guilfoile; Mark H. Forsyth; Alexander D. Harris; et al.

  Cluster k mycobacteriophages: Insights into the evolutionary origins of mycobacteriophage tm4

  PLoS ONE. 2011;6(10).
  5

• 27.

  2010

  Rainer Kalscheuer; Brian Weinrick; Usha Veeraraghavan; Gurdyal S. Besra; William R. Jacobs Jr.

  Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis

  Proceedings of the National Academy of Sciences of the United States of America. 2010;107(50):21761-21766.
  10

• 28.

  2010

  Anthony D. Baughn; Jiaoyu Deng; Catherine Vilchèze; Angelica Riestra; John T. Welch; William R. Jacobs Jr.; Oren Zimhony

  Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy

  Antimicrobial Agents and Chemotherapy. 2010;54(12):5323-5328.
  2

• 29.

  2010

  Virginie Molle; Gulcin Gulten; Catherine Vilchèze; Romain Veyron-Churlet; Isabelle Zanella-Cléon; James C. Sacchettini; William R. Jacobs Jr; Laurent Kremer

  Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis

  Molecular Microbiology. 2010;78(6):1591-1605.
  10

• 30.

  2010

  Rainer Kalscheuer; William R. Jacobs Jr.

  The significance of GlgE as a new target for tuberculosis

  Drug News and Perspectives. 2010;23(10):619-624.
  2

• 31.

  2010

  Feng Wang; Paras Jain; Gulcin Gulten; Zhen Liu; Yicheng Feng; Krishna Ganesula; Alifiya S. Motiwala; Thomas R. Ioerger; David Alland; Catherine Vilchèze; et al.

  Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid

  Antimicrobial Agents and Chemotherapy. 2010;54(9):3776-3782.
  15

• 32.

  2010

  Eszter Lázár-Molnár; Bing Chen; Kari A. Sweeney; Emilie J. Wang; Weijun Liu; Juan Lin; Steven A. Porcelli; Steven C. Almo; Stanley G. Nathenson; William R. Jacobs Jr.

  Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

  Proceedings of the National Academy of Sciences of the United States of America. 2010;107(30):13402-13407.
  25

• 33.

  2010

  Thomas R. Ioerger; Yicheng Feng; Krishna Ganesula; Xiaohua Chen; Karen M. Dobos; Sarah Fortune; William R. Jacobs Jr.; Valerie Mizrahi; Tanya Parish; et al.

  Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories

  Journal of Bacteriology. 2010;192(14):3645-3653.
  31

• 34.

  2010

  Michelle H. Larsen; William R. Jacobs; Steven A. Porcelli; John Kim; Uma Devi K. Ranganathan; Glenn J. Fennelly

  Balancing safety and immunogenicity in live-attenuated mycobacterial vaccines for use in humans at risk for HIV: Response to Misleading comments in Ranganathan et al. "Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice"

  Vaccine. 2010;28(21):3633-3634.
  0

• 35.

  2010

  Rainer Kalscheuer; Karl Syson; Usha Veeraraghavan; Brian Weinrick; Karolin E. Biermann; Zhen Liu; James C. Sacchettini; Gurdyal Besra; Stephen Bornemann; William R. Jacobs Jr.

  Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway

  Nature Chemical Biology. 2010;6(5):376-384.
  25

• 36.

  2010

  Catherine Vilchèze; Brian Weinrick; Ka-Wing Wong; Bing Chen; William Jacobs Jr.

  NAD⁺ auxotrophy is bacteriocidal for the tubercle bacilli

  Molecular Microbiology. 2010;76(2):365-377.
  7

• 37.

  2010

  Patamaporn Pruksakorn; Masayoshi Arai; Naoyuki Kotoku; Catherine Vilchze; Anthony D. Baughn; Prashini Moodley; William R. Jacobs Jr.; Motomasa Kobayashi

  Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

  Bioorganic and Medicinal Chemistry Letters. 2010;20(12):3658-3663.
  15

• 38.

  2010

  Arvind G. Kinhikar; Indu Verma; Dinesh Chandra; Krishna K. Singh; Karin Weldingh; Peter Andersen; Tsungda Hsu; William R. Jacobs Jr; Suman Laal

  Potential role for ESAT6 in dissemination of M. tuberculosis via human lung epithelial cells

  Molecular Microbiology. 2010;75(1):92-106.
  13

• 39.

  2009

  Jenna K. Capyk; Rainer Kalscheuer; Gordon R. Stewart; Jie Liu; Hyukin Kwon; Rafael Zhao; Sachi Okamoto; William R. Jacobs Jr.; Lindsay D. Eltis; William W. Mohn

  Mycobacterial cytochrome P450 125 (Cyp125) catalyzes the terminal hydroxylation of C27 steroids

  Journal of Biological Chemistry. 2009;284(51):35534-35542.
  30

• 40.

  2009

  Uma Devi K. Ranganathan; Michelle H. Larsen; John Kim; Steven A. Porcelli; William R. Jacobs Jr.; Glenn J. Fennelly

  Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8⁺ T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice

  Vaccine. 2009;28(1):152-161.
  11

• 41.

  2009

  Ivan P. Nascimento; Waldely O. Dias; Wagner Quintilio; Tsungda Hsu; William R. Jacobs Jr.; Luciana C.C. Leite

  Construction of an unmarked recombinant BCG expressing a pertussis antigen by auxotrophic complementation: Protection against Bordetella pertussis challenge in neonates

  Vaccine. 2009;27(52):7346-7351.
  5

• 42.

  2009

  Thomas R. Loerger; Sunwoo Koo; Eun-Gyu No; Xiaohua Chen; Michelle H. Larsen; William R. Jacobs Jr.; Manormoney Pillay; A. Willem Sturm; James C. Sacchettini

  Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa

  PLoS ONE. 2009;4(11).
  38

• 43.

  2009

  Anthony D. Baughn; Scott J. Garforth; Catherine Vilchèze; William R. Jacobs Jr.

  An anaerobic-type α-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis

  PLoS Pathogens. 2009;5(11).
  14

• 44.

  2009

  Charles F. Capinos Scherer; Janice J. Endsley; Juliana B. De Aguiar; William R. Jacobs Jr; Michelle H. Larsen; Mitchell. V. Palmer; Brian J. Nonnecke; W. Ray Waters; D. Mark Estes

  Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with mycobacterium bovis BCG or M. bovisΔRD1

  Transboundary and Emerging Diseases. 2009;56(6-7):228-239.
  5

• 45.

  2009

  Manjunatha M. Venkataswamy; Andres Baena; Michael F. Goldberg; Gabriel Bricard; Jin S. Im; John Chan; Faye Reddington; Gurdyal S. Besra; William R. Jacobs Jr.; Steven A. Porcelli

  Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guérin

  Journal of Immunology. 2009;183(3):1644-1656.
  15

• 46.

  2009

  W. Ray Waters; Mitchell V. Palmer; Brian J. Nonnecke; Tyler C. Thacker; D. Mark Estes; Michelle H. Larsen; William R. Jacobs Jr.; Peter Andersen; James McNair; F.C. Minion; et al.

  Signal regulatory protein α (SIRPα)⁺ cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria

  PLoS ONE. 2009;4(7).
  3

• 47.

  2009

  Michelle H. Larsen; Karolin Biermann; Bing Chen; Tsungda Hsu; Vasan K. Sambandamurthy; Andrew A. Lackner; Pyone Pyone Aye; Peter Didier; Dan Huang; Linyun Shao; et al.

  Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates

  Vaccine. 2009;27(34):4709-4717.
  31

• 48.

  2009

  Marcela Parra; Amy L. Yang; JaeHyun Lim; Kristopher Kolibab; Steven Derrick; Nathalie Cadieux; Liyanage P. Perera; William R. Jacobs; Michael Brennan; Sheldon L. Morris

  Development of a murine mycobacterial growth inhibition assay for evaluating vaccines against Mycobacterium tuberculosis

  Clinical and Vaccine Immunology. 2009;16(7):1025-1032.
  13

• 49.

  2009

  Radha Gopalaswamy; Sujatha Narayanan; Bing Chen; William R. Jacobs; Yossef Av-Gay

  The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection

  FEMS Microbiology Letters. 2009;295(1):23-29.
  11

• 50.

  2009

  Mark J. Cayabyab; Birgit Korioth-Schmitz; Yue Sun; Angela Carville; Harikrishnan Balachandran; Ayako Miura; Kevin R. Carlson; Adam P. Buzby; Barton F. Haynes; William R. Jacobs; et al.

  Recombinant Mycobacterium bovis BCG prime-recombinant adenovirus boost vaccination in rhesus monkeys elicits robust polyfunctional simian immunodeficiency virus-specific T-cell responses

  Journal of Virology. 2009;83(11):5505-5513.
  18

• 51.

  2009

  Suat L. G. Cirillo; Selvakumar Subbian; Bing Chen; Torin R. Weisbrod; William R. Jacobs Jr.; Jeffrey D. Cirillo

  Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination

  Infection and Immunity. 2009;77(6):2557-2567.
  13

• 52.

  2009

  Crystal Y. Chen; Dan Huang; Richard C. Wang; Ling Shen; Gucheng Zeng; Shuyun Yao; Yun Shen; Lisa Halliday; Jeff Fortman; Milton McAllister; et al.

  A critical role for CD8 T cells in a nonhuman primate model of tuberculosis

  PLoS Pathogens. 2009;5(4).
  43

• 53.

  2009

  Mariana Piuri; William R. Jacobs Jr.; Graham F. Hatfull

  Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis

  PLoS ONE. 2009;4(3).
  15

• 54.

  2009

  R. Colangeli; A. Haq; V.L. Arcus; E. Summers; R.S. Magliozzo; A. McBride; A.K. Mitra; M. Radjainia; A. Khajo; W.R. Jacobs Jr.; et al.

  The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates

  Proceedings of the National Academy of Sciences of the United States of America. 2009;106(11):4414-4418.
  22

• 55.

  2009

  Janice J. Endsley; W. Ray Waters; Mitchell V. Palmer; Brian J. Nonnecke; Tyler C. Thacker; William R. Jacobs Jr.; Michelle H. Larsen; Alison Hogg; Elisabeth Shell; Martin McAlauy; et al.

  The calf model of immunity for development of a vaccine against tuberculosis

  Veterinary Immunology and Immunopathology. 2009;128(1-3):199-204.
  9

• 56.

  2009

  Katherine C. Yam; Igor D'Angelo; Rainer Kalscheuer; Haizhong Zhu; Jian-Xin Wang; Victor Snieckus; Lan H. Ly; Paul J. Converse; William R. Jacobs Jr.; et al.

  Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis

  PLoS Pathogens. 2009;5(3).
  45

• 57.

  2009

  Dawn M. Zimmerman; W. Ray Waters; Konstantin P. Lyashchenko; Brian J. Nonnecke; Douglas L. Armstrong; William R. Jacobs Jr.; Michelle H. Larsen; Erin Egan; Gregg A. Dean

  Safety and immunogenicity of the Mycobacterium tuberculosis ΔlysA ΔpanCD vaccine in domestic cats infected with feline immunodeficiency virus

  Clinical and Vaccine Immunology. 2009;16(3):427-429.
  2

• 58.

  2009

  W. Ray Waters; Mitchell V. Palmer; Brian J. Nonnecke; Tyler C. Thacker; Charles F. Capinos Scherer; D. Mark Estes; R. Glyn Hewinson; H. Martin Vordermeier; S. Whitney Barnes; Glenn C. Federe; et al.

  Efficacy and immunogenicity of Mycobacterium bovis ΔRD1 against aerosol M. bovis infection in neonatal calves

  Vaccine. 2009;27(8):1201-1209.
  17

• 59.

  2009

  Joel S. Freundlich; Feng Wang; Catherine Vilchèze; Gulcin Gulten; Robert Langley; Guy A. Schiehser; David P. Jacobus; William R. Jacobs Jr.; James C. Sacchettini

  Triclosan derivatives: Towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis

  ChemMedChem. 2009;4(2):241-248.
  29

• 60.

  2009

  Warren L. Lee; Benjamin Gold; Crystal Darby; Nathan Brot; Xiuju Jiang; Luiz Pedro S. De Carvalho; Daniel Wellner; Gregory St. John; William R. Jacobs Jr.; Carl Nathan

  Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite

  Molecular Microbiology. 2009;71(3):583-593.
  12

• 61.

  2009

  JaeHyun Lim; Steven C. Derrick; Kristopher Kolibab; Amy Li Yang; Steven Porcelli; William R. Jacobs; Sheldon L. Morris

  Early pulmonary cytokine and chemokine responses in mice immunized with three different vaccines against Mycobacterium tuberculosis determined by PCR array

  Clinical and Vaccine Immunology. 2009;16(1):122-126.
  11

• 62.

  2009

  Niaz Banaei; Eleanor Z. Kincaid; S.-Y. Grace Lin; Edward Desmond; William R. Jacobs Jr.; Joel D. Ernst

  Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green

  Antimicrobial Agents and Chemotherapy. 2009;53(9):3799-3802.
  7

• 63.

  2009

  Jiemin Chen; Jordan Kriakov; Albel Singh; William R. Jacobs Jr.; Gurdyal S. Besra; Apoorva Bhatt

  Defects in glycopeptidolipid biosynthesis confer phage I3 resistance in Mycobacterium smegmatis

  Microbiology. 2009;155(12):4050-4057.
  4

• 64.

  2009

  Apoorva Bhatt; William R Jacobs Jr.

  Gene essentiality testing in mycobacterium smegmatis using specialized transduction.

  Methods in molecular biology (Clifton, N.J.). 2009;465:325-336.
  0

• 65.

  2008

  Susan M. Bueno; Pablo A. González; Kelly M. Cautivo; Jorge E. Mora; Eduardo D. Leiva; Hugo E. Tobar; Glenn J. Fennelly; Eliseo A. Eugenin; William R. Jacobs Jr.; et al.

  Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG

  Proceedings of the National Academy of Sciences of the United States of America. 2008;105(52):20822-20827.
  19

• 66.

  2008

  Min Yu; T.R. Santha Kumar; Louis J. Nkrumah; Alida Coppi; Silke Retzlaff; Celeste D. Li; Brendan J. Kelly; Pedro A. Moura; Viswanathan Lakshmanan; Joel S. Freundlich; et al.

  The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

  Cell Host and Microbe. 2008;4(6):567-578.
  84

• 67.

  2008

  Liyou Qiu; Dan Huang; Crystal Y. Chen; Richard Wang; Ling Shen; Yun Shen; Robert Hunt; James Estep; Barton F. Haynes; William R. Jacobs Jr.; et al.

  Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1α, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-β, TIM1, and TLR2 but low antigen-specific cellular responses

  Journal of Infectious Diseases. 2008;198(10):1514-1519.
  31

• 68.

  2008

  Vanaja Kumar; Prabakaran Loganathan; Gomathi Sivaramakrishnan; Jordan Kriakov; Azger Dusthakeer; Balaji Subramanyam; John Chan; William R. Jacobs Jr.; Narayanan Paranji Rama

  Characterization of temperate phage Che12 and construction of a new tool for diagnosis of tuberculosis

  Tuberculosis. 2008;88(6):616-623.
  10

• 69.

  2008

  Catherine Vilchèze; Yossef Av-Gay; Rodgoun Attarian; Zhen Liu; Manzour H. Hazbón; Roberto Colangeli; Bing Chen; Weijun Liu; David Alland; James C. Sacchettini; et al.

  Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis

  Molecular Microbiology. 2008;69(5):1316-1329.
  32

• 70.

  2008

  Masayoshi Arai; Mari Sobou; Catherine Vilchéze; Anthony Baughn; Hiroyuki Hashizume; Patamaporn Pruksakorn; Shunsuke Ishida; Makoto Matsumoto; William R. Jacobs Jr.; Motomasa Kobayashi

  Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent

  Bioorganic and Medicinal Chemistry. 2008;16(14):6732-6736.
  20

• 71.

  2008

  Anil K. Ojha; Anthony D. Baughn; Dhinakaran Sambandan; Tsungda Hsu; Xavier Trivelli; Yann Guerardel; Anuradha Alahari; Laurent Kremer; William R. Jacobs Jr.; et al.

  Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria

  Molecular Microbiology. 2008;69(1):164-174.
  56

• 72.

  2008

  Nilofar N. MohamedMohaideen; Satheesh K. Palaninathan; Paul M. Morin; Brad J. Williams; Miriam Braunstein; Shane E. Tichy; Joseph Locker; David H. Russell; William R. Jacobs Jr.; et al.

  Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis

  Biochemistry. 2008;47(23):6092-6102.
  24

• 73.

  2008

  Arun K. Mishra; Luke J. Alderwick; Doris Rittmann; Cindy Wang; Apoorva Bhatt; William R. Jacobs Jr.; Kuni Takayama; Lothar Eggeling; Gurdyal S. Besra

  Identification of a novel α(1→6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant

  Molecular Microbiology. 2008;68(6):1595-1613.
  25

• 74.

  2008

  Dee N. Dao; Kari Sweeney; Tsungda Hsu; Sudagar S. Gurcha; Ivan P. Nascimento; Dan Roshevsky; Gurdyal S. Besra; John Chan; Steven A. Porcelli; William R. Jacobs Jr.

  Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production

  PLoS Pathogens. 2008;4(6).
  33

• 75.

  2008

  Jin S. Im; Tae-Jin Kang; Seong-Beom Lee; Chi-Hong Kim; Sang-Haak Lee; Manjunatha M. Venkataswamy; Evan R. Serfass; Bing Chen; Petr A. Illarionov; Gurdyal S. Besra; et al.

  Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

  Clinical Immunology. 2008;127(2):214-224.
  12

• 76.

  2008

  Deepak Jayakumar; William R. Jacobs Jr.; Sujatha Narayanan

  Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection

  Cellular Microbiology. 2008;10(2):365-374.
  21

• 77.

  2008

  Radha Gopalaswamy; Sujatha Narayanan; William R. Jacobs Jr.; Yossef Av-Gay

  Mycobacterium smegmatis biofilm formation and sliding motility are affected by the serine/threonine protein kinase PknF

  FEMS Microbiology Letters. 2008;278(1):121-127.
  12

• 78.

  2008

  Niaz Banaiee; Vanessa January; Charmaine Barthus; Maureen Lambrick; Denise RoDiti; Marcel A. Behr; William R. Jacobs Jr.; Lafras M. Steyn

  Evaluation of a semi-automated reporter phage assay for susceptibility testing of Mycobacterium tuberculosis isolates in South Africa

  Tuberculosis. 2008;88(1):64-68.
  15

• 79.

  2008

  Manchi C.M. Reddy; Kuppan Gokulan; William R. Jacobs Jr.; Thomas R. Ioerger; James C. Sacchettini

  Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response

  Protein Science. 2008;17(1):159-170.
  6

• 80.

  2008

  Dan Huang; Yun Shen; Liyou Qiu; Crystal Y. Chen; Ling Shen; Jim Estep; Robert Hunt; Daphne Vasconcelos; George Du; Pyone Aye; et al.

  Immune distribution and localization of phosphoantigen-specific Vγ2Vδ2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection

  Infection and Immunity. 2008;76(1):426-436.
  30

• 81.

  2008

  Steven A. Porcelli; William R. Jacobs Jr.

  Tuberculosis: Unsealing the apoptotic envelope

  Nature Immunology. 2008;9(10):1101-1102.
  22

• 82.

  2008

  Paul Gratraud; Enlli Huws; Brie Falkard; Sophie Adjalley; David A Fidock; Laurence Berry; William R Jacobs Jr.; Mark S Baird; Henri Vial; et al.

  Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target.

  PloS one. 2008;4(9):e6889.
  2

• 83.

  2007

  W. Ray Waters; Mitchell V. Palmer; Brian J. Nonnecke; Tyler C. Thacker; Charles F. Capinos Scherer; D. Mark Estes; William R. Jacobs Jr.; Aharona Glatman-Freedman; Michelle H. Larsen

  Failure of a Mycobacterium tuberculosis ΔRD1 ΔpanCD double deletion mutant in a neonatal calf aerosol M. bovis challenge model: Comparisons to responses elicited by M. bovis bacille Calmette Guerin

  Vaccine. 2007;25(45):7832-7840.
  13

• 84.

  2007

  Ban Al-Sayyed; Sajida Piperdi; Xinni Yuan; Anping Li; Gurdyal S. Besra; William R. Jacobs Jr.; Arturo Casadevall; Aharona Glatman-Freedman

  Monoclonal antibodies to Mycobacterium tuberculosis CDC 1551 reveal subcellular localization of MPT51

  Tuberculosis. 2007;87(6):489-497.
  1

• 85.

  2007

  Yongkai Mo; Natalie M. Quanquin; William H. Vecino; Uma Devi Ranganathan; Lydia Tesfa; William Bourn; Keith M. Derbyshire; Norman L. Letvin; William R. Jacobs Jr.; Glenn J. Fennelly

  Genetic alteration of Mycobacterium smegmatis to improve mycobacterium-mediated transfer of plasmid DNA into mammalian cells and DNA immunization

  Infection and Immunity. 2007;75(10):4804-4816.
  5

• 86.

  2007

  Rachel Pinto; Joseph S. Harrison; Tsungda Hsu; William R. Jacobs Jr.; Thomas S. Leyh

  Sulfite reduction in mycobacteria

  Journal of Bacteriology. 2007;189(18):6714-6722.
  8

• 87.

  2007

  Joel S. Freundlich; Feng Wang; Han-Chun Tsai; Mack Kuo; Hong-Ming Shieh; John W. Anderson; Louis J. Nkrumah; Juan-Carlos Valderramos; Min Yu; T. R. Santha Kumar; et al.

  X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy

  Journal of Biological Chemistry. 2007;282(35):25436-25444.
  30

• 88.

  2007

  Robert T. Glover; Jordan Kriakov; Scott J. Garforth; Anthony D. Baughn; William R. Jacobs Jr.

  The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis

  Journal of Bacteriology. 2007;189(15):5495-5503.
  21

• 89.

  2007

  Niaz Banaiee; William R. Jacobs; Joel D. Ernst

  LspA-independent action of globomycin on Mycobacterium tuberculosis

  Journal of Antimicrobial Chemotherapy. 2007;60(2):414-416.
  4

• 90.

  2007

  Michelle H Larsen; Karolin Biermann; William R Jacobs Jr.

  Laboratory maintenance of Mycobacterium tuberculosis.

  Current protocols in microbiology. 2007;Chapter 10:Unit 10A.1.
  10

• 91.

  2007

  Michelle H Larsen; Karolin Biermann; William R Jacobs Jr.

  Analyses of Mycobacterium tuberculosis proteins.

  Current protocols in microbiology. 2007;Chapter 10:Unit 10A.4.
  1

• 92.

  2007

  Joseph Hinchey; Sunhee Lee; Bo Y. Jeon; Randall J. Basaraba; Manjunatha M. Venkataswamy; Bing Chen; John Chan; Miriam Braunstein; Ian M. Orme; Steven C. Derrick; et al.

  Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis

  Journal of Clinical Investigation. 2007;117(8):2279-2288.
  121

• 93.

  2007

  Jae-Sung Yu; James W. Peacock; William R. Jacobs Jr.; Richard Frothingham; Norman L. Letvin; Hua-Xin Liao; Barton F. Haynes

  Recombinant Mycobacterium bovis bacillus Calmette-Guérin elicits human immunodeficiency virus type 1 envelope-specific T lymphocytes at mucosal sites

  Clinical and Vaccine Immunology. 2007;14(7):886-893.
  9

• 94.

  2007

  Kamalakannan Velmurugan; Bing Chen; Jessica L Miller; Sharon Azogue; Serdar Gurses; Tsungda Hsu; Michael Glickman; William R Jacobs Jr.; Steven A Porcelli; Volker Briken

  Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells.

  PLoS pathogens. 2007;3(7):e110.
  64

• 95.

  2007

  Silvana C. Ngo; Oren Zimhony; Jin Chung Woo; Halimah Sayahi; William R. Jacobs Jr.; John T. Welch

  Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs

  Antimicrobial Agents and Chemotherapy. 2007;51(7):2430-2435.
  18

• 96.

  2007

  A.C. Murillo; H.Y. Li; T. Alber; E.N. Baker; J.M. Berger; L.T. Cherney; M.M. Cherney; Yoon Song Cho; D. Eisenberg; C.R. Garen; et al.

  High throughput crystallography of TB drug targets

  Infectious Disorders - Drug Targets. 2007;7(2):127-139.
  24

• 97.

  2007

  Roberto Colangeli; Danica Helb; Catherine Vilchèze; Manzour Hernando Hazbón; Chee-Gun Lee; Hassan Safi; Brendan Sayers; Irene Sardone; Marcus B Jones; Robert D Fleischmann; et al.

  Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis.

  PLoS pathogens. 2007;3(6):e87.
  10

• 98.

  2007

  Apoorva Bhatt; Virginie Molle; Gurdyal S. Besra; William R. Jacobs Jr.; Laurent Kremer

  The Mycobacterium tuberculosis FAS-II condensing enzymes: Their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development

  Molecular Microbiology. 2007;64(6):1442-1454.
  44

• 99.

  2007

  Catherine Vilchèze; William R Jacobs

  Isolation and analysis of Mycobacterium tuberculosis mycolic acids.

  Current protocols in microbiology. 2007;Chapter 10:Unit 10A.3.
  1

• 100.

  2007

  Apoorva Bhatt; Nagatoshi Fujiwara; Kiranmai Bhatt; Sudagar S. Gurcha; Laurent Kremer; Bing Chen; John Chan; Steven A. Porcelli; Kazuo Kobayashi; Gurdyal S. Besra; et al.

  Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice

  Proceedings of the National Academy of Sciences of the United States of America. 2007;104(12):5157-5162.
  69

• 101.

  2007

  Steven C. Derrick; Teresa H. Evering; Vasan K. Sambandamurthy; Kripa V. Jalapathy; Tsungda Hsu; Bing Chen; Mei Chen; Robert G. Russell; Ana Paula Junqueira-Kipnis; Ian M. Orme; et al.

  Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine

  Immunology. 2007;120(2):192-206.
  16

• 102.

  2007

  Kiranmai Bhatt; Sudagar S. Gurcha; Apoorva Bhatt; Gurdyal S. Besra; William R. Jacobs Jr.

  Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis

  Microbiology. 2007;153(2):513-520.
  20

• 103.

  2007

  Oren Zimhony; Catherine Vilchèze; Masayoshi Arai; John T. Welch; William R. Jacobs Jr.

  Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli

  Antimicrobial Agents and Chemotherapy. 2007;51(2):752-754.
  28

• 104.

  2007

  Feng Wang; Robert Langley; Gulcin Gulten; Lynn G. Dover; Gurdyal S. Besra; William R. Jacobs Jr.; James C. Sacchettini

  Mechanism of thioamide drug action against tuberculosis and leprosy

  Journal of Experimental Medicine. 2007;204(1):73-78.
  74

• 105.

  2007

  Avi-Hai Hovav; Mark J. Cayabyab; Michael W. Panas; Sampa Santra; John Greenland; Ralf Geiben; Barton F. Haynes; William R. Jacobs Jr.; Norman L. Letvin

  Rapid memory CD8⁺ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis

  Journal of Virology. 2007;81(1):74-83.
  17

• 106.

  2007

  Catherine Vilchèze; William R. Jacobs Jr.

  The mechanism of isoniazid killing: Clarity through the scope of genetics

  Annual Review of Microbiology. 2007;61:35-50.
  68

• 107.

  2006

  Jae-Sung Yu; James W. Peacock; Stacie Vanleeuwen; Tsungda Hsu; William R. Jacobs Jr.; Mark J. Cayabyab; Norman L. Letvin; Richard Frothingham; Herman F. Staats; Hua-Xin Liao; et al.

  Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis

  Clinical and Vaccine Immunology. 2006;13(11):1204-1211.
  13

• 108.

  2006

  N. Banaiee; W.R. Jacobs Jr.; J.D. Ernst

  Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages

  Infection and Immunity. 2006;74(11):6449-6457.
  26

• 109.

  2006

  Sunhee Lee; Bo-Young Jeon; Svetoslav Bardarov; Mei Chen; Sheldon L. Morris; William R. Jacobs Jr.

  Protection elicited by two glutamine auxotrophs of Mycobacterium tuberculosis and in vivo growth phenotypes of the four unique glutamine synthetase mutants in a murine model

  Infection and Immunity. 2006;74(11):6491-6495.
  10

• 110.

  2006

  Ana Paula Junqueira-Kipnis; Randall J. Basaraba; Veronica Gruppo; Gopinath Palanisamy; Oliver C. Turner; Tsungda Hsu; William R. Jacobs Jr.; Scott A. Fulton; Scott M. Reba; et al.

  Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-γ

  Immunology. 2006;119(2):224-231.
  14

• 111.

  2006

  Jacqueline Pérez; Rósula Garcia; Horacio Bach; Jacobus H. de Waard; William R. Jacobs Jr.; Yossef Av-Gay; Jose Bubis; Howard E. Takiff

  Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD

  Biochemical and Biophysical Research Communications. 2006;348(1):6-12.
  27

• 112.

  2006

  Vasan K. Sambandamurthy; Steven C. Derrick; Tsungda Hsu; Bing Chen; Michelle H. Larsen; Kripa V. Jalapathy; Mei Chen; John Kim; Steven A. Porcelli; John Chan; et al.

  Mycobacterium tuberculosis ΔRD1 ΔpanCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis

  Vaccine. 2006;24(37-39):6309-6320.
  61

• 113.

  2006

  Catherine Vilchèze; Feng Wang; Masayoshi Arai; Manzour Hernando Hazbón; Roberto Colangeli; Laurent Kremer; Torin R. Weisbrod; David Alland; James C. Sacchettini; William R. Jacobs Jr.

  Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid

  Nature Medicine. 2006;12(9):1027-1029.
  83

• 114.

  2006

  Louis J. Nkrumah; Rebecca A. Muhle; Pedro A. Moura; Pallavi Ghosh; Graham F. Hatfull; William R. Jacobs Jr.; David A. Fidock

  Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase

  Nature Methods. 2006;3(8):615-621.
  63

• 115.

  2006

  Graham F Hatfull; Marisa L Pedulla; Deborah Jacobs-Sera; Pauline M Cichon; Amy Foley; Michael E Ford; Rebecca M Gonda; Jennifer M Houtz; Andrew J Hryckowian; Vanessa A Kelchner; et al.

  Exploring the mycobacteriophage metaproteome: phage genomics as an educational platform.

  PLoS genetics. 2006;2(6):e92.
  30

• 116.

  2006

  Vivekanandhan Aravindhan; Sujatha Narayanan; Namasivayam Gautham; Vinayaka Prasad; P. Kannan; William R. Jacobs Jr.; Paranji R. Narayanan

  T-h-2 immunity and CD3⁺ CD45RB^low-activated T cells in mice immunized with recombinant bacillus Calmette-Guérin expressing HIV-1 principal neutralizing determinant epitope

  FEMS Immunology and Medical Microbiology. 2006;47(1):45-55.
  4

• 117.

  2006

  Vivek Rao; Feng Gao; Bing Chen; William R. Jacobs Jr.; Michael S. Glickman

  Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis-induced inflammation and virulence

  Journal of Clinical Investigation. 2006;116(6):1660-1667.
  70

• 118.

  2006

  JoAnn M. Tufariello; Kaixia Mi; Jiayong Xu; Yukari C. Manabe; Anup K. Kesavan; Joshua Drumm; Kathryn Tanaka; William R. Jacobs Jr.; John Chan

  Deletion of the Mycobacterium tuberculosis resuscitation-promoting factor Rv1009 gene results in delayed reactivation from chronic tuberculosis

  Infection and Immunity. 2006;74(5):2985-2995.
  43

• 119.

  2006

  Joel S. Freundlich; Min Yu; Edinson Lucumi; MacK Kuo; Han-Chun Tsai; Juan-Carlos Valderramos; Luchezar Karagyozov; William R. Jacobs Jr.; Guy A. Schiehser; David A. Fidock; et al.

  Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2′-Substituted triclosan derivatives

  Bioorganic and Medicinal Chemistry Letters. 2006;16(8):2163-2169.
  29

• 120.

  2006

  V.A. Govan; N.D. Christensen; C. Berkower; W.R. Jacobs Jr.; A.-L. Williamson

  Immunisation with recombinant BCG expressing the cottontail rabbit papillomavirus (CRPV) L1 gene provides protection from CRPV challenge

  Vaccine. 2006;24(12):2087-2093.
  22

• 121.

  2006

  Eleanor Roy; A. Dharshan De Silva; Vasan K. Sambandamurthy; Simon O. Clark; Evangelos Stavropoulos; William R. Jacobs Jr.; John Brennan; John Chan; Ann Williams; M. Joseph Colston; et al.

  Induction of high levels of protective immunity in mice after vaccination using dendritic cells infected with auxotrophic mutants of Mycobacterium tuberculosis

  Immunology Letters. 2006;103(2):196-199.
  3

• 122.

  2006

  Niaz Banaiee; Eleanor Z. Kincaid; Ulrike Buchwald; William R. Jacobs Jr.; Joel D. Ernst

  Potent inhibition of macrophage responses to IFN-γ by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2

  Journal of Immunology. 2006;176(5):3019-3027.
  63

• 123.

  2006

  Hector R. Morbidoni; Catherine Vilchèze; Laurent Kremer; Robert Bittman; James C. Sacchettini; William R. Jacobs Jr.

  Dual Inhibition of Mycobacterial Fatty Acid Biosynthesis and Degradation by 2-Alkynoic Acids

  Chemistry and Biology. 2006;13(3):297-307.
  13

• 124.

  2006

  Mark J. Cayabyab; Avi-Hai Hovav; Tsungda Hsu; Georgia R. Krivulka; Michelle A. Lifton; Darci A. Gorgone; Glenn J. Fennelly; Barton F. Haynes; William R. Jacobs Jr.; Norman L. Letvin

  Generation of CD8⁺ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 env

  Journal of Virology. 2006;80(4):1645-1652.
  30

• 125.

  2005

  Anil Ojha; Mridula Anand; Apoorva Bhatt; Laurent Kremer; William R. Jacobs Jr.; Graham F. Hatfull

  GroEL1: A dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria

  Cell. 2005;123(5):861-873.
  100

• 126.

  2005

  Joel S. Freundlich; John W. Anderson; Dimitri Sarantakis; Hong-Ming Shieh; Min Yu; Juan-Carlos Valderramos; Edinson Lucumi; MacK Kuo; William R. Jacobs Jr.; David A. Fidock; et al.

  Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives

  Bioorganic and Medicinal Chemistry Letters. 2005;15(23):5247-5252.
  37

• 127.

  2005

  Apoorva Bhatt; Laurent Kremer; Annie Z. Dai; James C. Sacchettini; William R. Jacobs Jr.

  Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis

  Journal of Bacteriology. 2005;187(22):7596-7606.
  43

• 128.

  2005

  Vasan K. Sambandamurthy; William R. Jacobs Jr.

  Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis

  Microbes and Infection. 2005;7(5-6):955-961.
  37

• 129.

  2005

  Roberto Colangeli; Danica Helb; Sudharsan Sridharan; Jingchuan Sun; Mandira Varma-Basil; Manzour Hernando Hazbón; Ryhor Harbacheuski; Nicholas J. Megjugorac; William R. Jacobs Jr.; et al.

  The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol

  Molecular Microbiology. 2005;55(6):1829-1840.
  65

• 130.

  2005

  Catherine Vilchèze; Torin R. Weisbrod; Bing Chen; Laurent Kremer; Manzour H. Hazbón; Feng Wang; David Alland; James C. Sacchettini; William R. Jacobs Jr.

  Altered NADH/NAD⁺ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria

  Antimicrobial Agents and Chemotherapy. 2005;49(2):708-720.
  60

• 131.

  2005

  Vasan K. Sambandamurthy; Steven C. Derrick; Kripa V. Jalapathy; Bing Chen; Robert G. Russell; Sheldon L. Morris; William R. Jacobs Jr.

  Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis

  Infection and Immunity. 2005;73(2):1196-1203.
  57

• 132.

  2004

  Isamu Matsunaga; Apoorva Bhatt; David C. Young; Tan-Yun Cheng; Stephen J. Eyles; Gurdyal S. Besra; Volker Briken; Steven A. Porcelli; Catherine E. Costello; William R. Jacobs Jr.; et al.

  Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells

  Journal of Experimental Medicine. 2004;200(12):1559-1569.
  80

• 133.

  2004

  Sunhee Lee; Jordan Kriakov; Catherine Vilcheze; Zhiyan Dai; Graham F. Hatfull; William R. Jacobs Jr.

  Bxz1, a new generalized transducing phage for mycobacteria

  FEMS Microbiology Letters. 2004;241(2):271-276.
  19

• 134.

  2004

  Katherine B. Hisert; Meghan A. Kirksey; James E. Gomez; Alexandra O. Sousa; Jeffery S. Cox; William R. Jacobs Jr.; Carl F. Nathan; John D. McKinney

  Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening

  Infection and Immunity. 2004;72(9):5315-5321.
  30

• 135.

  2004

  William H. Vecino; Natalie M. Quanquin; Luis Martinez-Sobrido; Ana Fernandez-Sesma; Adolfo García-Sastre; William R. Jacobs Jr.; Glenn J. Fennelly

  Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge

  Virology. 2004;325(2):192-199.
  12

• 136.

  2004

  Aharona Glatman-Freedman; Arturo Casadevall; Zongdong Dai; William R. Jacobs Jr.; Anping Li; Sheldon L. Morris; Josepine Anne D. Navoa; Sajida Piperdi; John B. Robbins; Rachel Schneerson; et al.

  Antigenic evidence of prevalence and diversity of Mycobacterium tuberculosis arabinomannan

  Journal of Clinical Microbiology. 2004;42(7):3225-3231.
  15

• 137.

  2004

  Oren Zimhony; Catherine Vilchèze; William R. Jacobs Jr.

  Characterization of Mycobacterium smegmatis expressing the Mycobacterium tuberculosis fatty acid synthase I (fas1) gene

  Journal of Bacteriology. 2004;186(13):4051-4055.
  19

• 138.

  2004

  Samantha L. Sampson; Christopher C. Dascher; Vasan K. Sambandamurthy; Robert G. Russell; William R. Jacobs Jr.; Barry R. Bloom; Mary K. Hondalus

  Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs

  Infection and Immunity. 2004;72(5):3031-3037.
  40

• 139.

  2004

  D.N. Dao; L. Kremer; Y. Guérardel; A. Molano; W.R. Jacobs Jr.; S.A. Porcelli; V. Briken

  Mycobacterium tuberculosis Lipomannan Induces Apoptosis and Interleukin-12 Production in Macrophages

  Infection and Immunity. 2004;72(4):2067-2074.
  78

• 140.

  2004

  JoAnn M. Tufariello; William R. Jacobs Jr.; John Chan

  Individual Mycobacterium tuberculosis Resuscitation-Promoting Factor Homologues Are Dispensable for Growth In Vitro and In Vivo

  Infection and Immunity. 2004;72(1):515-526.
  44

• 141.

  2003

  Tsungda Hsu; Suzanne M. Hingley-Wilson; Bing Chen; Mei Chen; Annie Z. Dai; Paul M. Morin; Carolyn B. Marks; Jeevan Padiyar; Celia Goulding; Mari Gingery; et al.

  The primary mechanism of attenuation of bacillus Calmette-Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue

  Proceedings of the National Academy of Sciences of the United States of America. 2003;100(21):12420-12425.
  258

• 142.

  2003

  Manzour Hernando Hazbón; Nora Guarín; Beatriz Eugenia Ferro; Ana Lucía Rodríguez; Luz Angela Labrada; Rafael Tovar; Paul F. Riska; William R. Jacobs Jr.

  Photographic and luminometric detection of luciferase reporter phages for drug susceptibility testing of clinical Mycobacterium tuberculosis isolates

  Journal of Clinical Microbiology. 2003;41(10):4865-4869.
  31

• 143.

  2003

  Suzanne M. Hingley-Wilson; Vasan K. Sambandamurthy; William R. Jacobs Jr.

  Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis

  Nature Immunology. 2003;4(10):949-955.
  90

• 144.

  2003

  Hideaki Ohno; Guofeng Zhu; Vellore P. Mohan; Darien Chu; Shigeru Kohno; William R. Jacobs Jr.; John Chan

  The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis

  Cellular Microbiology. 2003;5(9):637-648.
  98

• 145.

  2003

  Joel Otero; William R. Jacobs Jr.; Michael S. Glickman

  Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transduction

  Applied and Environmental Microbiology. 2003;69(9):5039-5044.
  8

• 146.

  2003

  Sandra A. Consaul; William R. Jacobs Jr.; Martin S. Pavelka Jr.

  Extragenic suppression of the requirement for diaminopimelate in diaminopimelate auxotrophs of Mycobacterium smegmatis

  FEMS Microbiology Letters. 2003;225(1):131-135.
  4

• 147.

  2003

  Jordan Kriakov; Sun Hee Lee; William R. Jacobs Jr.

  Identification of a regulated alkaline phosphatase, a cell surface-associated lipoprotein, in Mycobacterium smegmatis

  Journal of Bacteriology. 2003;185(16):4983-4991.
  9

• 148.

  2003

  Martin S. Pavelka Jr.; Bing Chen; Cynthia L. Kelley; Frank M. Collins; William R. Jacobs Jr.

  Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis

  Infection and Immunity. 2003;71(7):4190-4192.
  35

• 149.

  2003

  Niaz Banaiee; Miriam Bobadilla-del-Valle; Paul F. Riska; Svetoslav Bardarov Jr.; Peter M. Small; Alfredo Ponce-de-Leon; William R. Jacobs Jr.; Graham F. Hatfull; Jose Sifuentes-Osornio

  Rapid identification and susceptibility testing of Mycobacterium tuberculosis from MGIT cultures with luciferase reporter mycobacteriophages

  Journal of Medical Microbiology. 2003;52(7):557-561.
  27

• 150.

  2003

  Laurent Kremer; Lynn G. Dover; Hector R. Morbidoni; Catherine Vilchèze; William N. Maughan; Alain Baulard; Shiao-Chun Tu; Nadine Honoré; Vojo Deretic; et al.

  Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria

  Journal of Biological Chemistry. 2003;278(23):20547-20554.
  42

• 151.

  2003

  Mack R. Kuo; Hector R. Morbidoni; David Alland; Scott F. Sneddon; Brian B. Gourlie; Mark M. Staveski; Marina Leonard; Jill S. Gregory; Andrew D. Janjigian; Christopher Yee; et al.

  Targeting tuberculosis and malaria through inhibition of enoyl reductase. Compound activity and structural data

  Journal of Biological Chemistry. 2003;278(23):20851-20859.
  108

• 152.

  2003

  Kuppan Gokulan; Bernhard Rupp; Martin S. Pavelka Jr.; William R. Jacobs Jr.; James C. Sacchettini

  Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis

  Journal of Biological Chemistry. 2003;278(20):18588-18596.
  37

• 153.

  2003

  Apoorva Bhatt; William R. Jacobs Jr.

  Conjugal rites of mycobacteria

  Nature Genetics. 2003;34(1):3-4.
  3

• 154.

  2003

  Marisa L. Pedulla; Michael E. Ford; Jennifer M. Houtz; Tharun Karthikeyan; Curtis Wadsworth; John A. Lewis; Debbie Jacobs-Sera; Jacob Falbo; Joseph Gross; Nicholas R. Pannunzio; et al.

  Origins of highly mosaic mycobacteriophage genomes

  Cell. 2003;113(2):171-182.
  281

• 155.

  2003

  Miriam Braunstein; Benjamin J. Espinosa; John Chan; John T. Belisle; William R. Jacobs Jr.

  SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis

  Molecular Microbiology. 2003;48(2):453-464.
  109

• 156.

  2003

  Vivek Sharma; Arulandu Arockiasamy; Donald R. Ronning; Christos G. Savva; Andreas Holzenburg; Miriam Braunstein; William R. Jacobs Jr.; James C. Sacchettini

  Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase

  Proceedings of the National Academy of Sciences of the United States of America. 2003;100(5):2243-2248.
  107

• 157.

  2003

  Svetoslav Bardarov Jr.; Horng Dou; Katherine Eisenach; Niaz Banaiee; Su Ya; John Chan; William R. Jacobs Jr.; Paul F. Riska

  Detection and drug-susceptibility testing of M. tuberculosis from sputum samples using luciferase reporter phage: Comparison with the Mycobacteria Growth Indicator Tube (MGIT) system

  Diagnostic Microbiology and Infectious Disease. 2003;45(1):53-61.
  30

• 158.

  2003

  T.C. Terwilliger; M.S. Park; G.S. Waldo; J. Berendzen; L.-W. Hung; C.-Y. Kim; C.V. Smith; J.C. Sacchettini; M. Bellinzoni; R. Bossi; et al.

  The TB structural genomics consortium: A resource for Mycobacterium tuberculosis biology

  Tuberculosis. 2003;83(4):223-249.
  68

• 159.

  2002

  Stoyan Bardarov; Svetoslav Bardarov Jr.; Martin S. Pavelka Jr.; Vasan Sambandamurthy; Micharov Larsen; JoAnn Tufariello; John Chan; Graham Hatfull; William R. Jacobs Jr.

  Specialized transduction: An efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis

  Microbiology. 2002;148(10):3007-3017.
  185

• 160.

  2002

  Vasan K. Sambandamurthy; Xiaojuan Wang; Bing Chen; Robert G. Russell; Steven Derrick; Frank M. Collins; Sheldon L. Morris; William R. Jacobs Jr.

  A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis

  Nature Medicine. 2002;8(10):1171-1174.
  140

• 161.

  2002

  J. Reid Schwebach; Bing Chen; Aharona Glatman-Freedman; Arturo Casadevall; John D. McKinney; John L. Harb; Patrick J. McGuire; W. Emmett Barkley; Barry R. Bloom; William R. Jacobs Jr.

  Infection of mice with aerosolized Mycobacterium tuberculosis: Use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility

  Applied and Environmental Microbiology. 2002;68(9):4646-4649.
  4

• 162.

  2002

  William H. Vecino; Paul M. Morin; Rabia Agha; William R. Jacobs Jr.; Glenn J. Fennelly

  Mucosal DNA vaccination with highly attenuated Shigella is superior to attenuated Salmonella and comparable to intramuscular DNA vaccination for T cells against HIV

  Immunology Letters. 2002;82(3):197-204.
  30

• 163.

  2002

  Remo Perozzo; Mack Kuo; Amar Bir Singh Sidhu; Jacob T. Valiyaveettil; Robert Bittman; William R. Jacobs Jr.; David A. Fidock; James C. Sacchettini

  Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase

  Journal of Biological Chemistry. 2002;277(15):13106-13114.
  129

• 164.

  2002

  Chih-Chin Huang; Clare V. Smith; Michael S. Glickman; William R. Jacobs; James C. Sacchettini

  Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis

  Journal of Biological Chemistry. 2002;277(13):11559-11569.
  103

• 165.

  2002

  Adrie J. C. Steyn; Desmond M. Collins; Mary K. Hondalus; William R. Jacobs Jr.; R. Pamela Kawakami; Barry R. Bloom

  Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth

  Proceedings of the National Academy of Sciences of the United States of America. 2002;99(5):3147-3152.
  133

• 166.

  2002

  Michelle H. Larsen; Catherine Vilchèze; Laurent Kremer; Gurdyal S. Besra; Linda Parsons; Max Salfinger; Leonid Heifets; Manzour H. Hazbon; David Alland; et al.

  Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in mycobacterium smegmatis, M. bovis BCG and M. tuberculosis

  Molecular Microbiology. 2002;46(2):453-466.
  77

• 167.

  2002

  Celia W. Goulding; Marcin Apostol; Daniel H. Anderson; Harindarpal S. Gill; Clare V. Smith; Mack R. Kuo; Jin KukYang; Geoffrey S. Waldo; Se Won Suh; Radha Chauhan; et al.

  The TB structural genomics consortium: Providing a structural foundation for drug discovery

  Current Drug Targets - Infectious Disorders. 2002;2(2):121-141.
  60

• 168.

  2002

  Esen Wooff; Stephen Ll. Michell; Stephen V. Gordon; Mark A. Chambers; Stoyan Bardarov; William R. Jacobs Jr.; R. Glyn Hewinson; Paul R. Wheeler

  Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo

  Molecular Microbiology. 2002;43(3):653-663.
  32

• 169.

  2002

  Patrick J. Brennan; Tom Terwilliger; Clifton E. Barry III; Claudia Manca; Hua Su; Michael Reed; Kerry Rutter; Pilar Domenech; Gilla Kaplan; Yong Jun Li; et al.

  The US-Japan Cooperative Medical Science Program Tuberculosis and Leprosy Panel's 36th annual research conference, New Orleans, Louisiana, USA, 15-17 July 2001

  Tuberculosis. 2002;82(2-3):113-135.
  0

• 170.

  2002

  Miriam Braunstein; Stoyan S. Bardarov; William R. Jacobs Jr.

  Genetic methods for deciphering virulence determinants of Mycobacterium tuberculosis

  Methods in Enzymology. 2002;358:67-99.
  36

• 171.

  2001

  Michael S. Glickman; William R. Jacobs Jr.

  Microbial pathogenesis of Mycobacterium tuberculosis: Dawn of a discipline

  Cell. 2001;104(4):477-485.
  140

• 172.

  2001

  Michael S. Glickman; Sean M. Cahill; William R. Jacobs Jr.

  The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase

  Journal of Biological Chemistry. 2001;276(3):2228-2233.
  73

• 173.

  2001

  N. Banaiee; M. Bobadilla-del-Valle; Jr. Bardarov S.; P.F. Riska; P.M. Small; A. Ponce-de-Leon; Jr. Jacobs W.R.; G.F. Hatfull; J. Sifuentes-Osornio

  Luciferase reporter mycobacteriophages for detection, identification, and antibiotic susceptibility testing of mycobacterium tuberculosis in Mexico

  Journal of Clinical Microbiology. 2001;39(11):3883-3888.
  39

• 174.

  2001

  J.R. Schwebach; Jr. Jacobs W.R.; A. Casadevall

  Sterilization of Mycobacterium tuberculosis Erdman samples by antimicrobial fixation in a biosafety level 3 laboratory

  Journal of Clinical Microbiology. 2001;39(2):769-771.
  9

• 175.

  2001

  M. Braunstein; A.M. Brown; S. Kurtz; Jr. Jacobs W.R.

  Two nonredundant SecA homologues function in mycobacteria

  Journal of Bacteriology. 2001;183(24):6979-6990.
  55

• 176.

  2000

  Oren Zimhony; Jeffery S. Cox; John T. Welch; Catherine Vilchèze; William R. Jacobs Jr.

  Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis

  Nature Medicine. 2000;6(9):1043-1047.
  86

• 177.

  2000

  John D. McKinney; Kerstin Höner Zu Bentrup; Ernesto J. Muñoz-Elias; Andras Miczak; Bing Chen; Wal-Tsing Chan; Dana Swenson; James C. Sacchettini; William R. Jacobs Jr.; David G. Russell

  Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

  Nature. 2000;406(6797):735-738.
  621

• 178.

  2000

  Vivek Sharma; Sujata Sharma; Kerstin Hoener Zu Bentrup; John D. McKinney; David G. Russell; William R. Jacobs Jr.; James C. Sacchettini

  Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis

  Nature Structural Biology. 2000;7(8):663-668.
  119

• 179.

  2000

  Catherine Vilchèze; Hector R. Morbidoni; Torin R. Weisbrod; Hiroyuki Iwamoto; Mack Kuo; James C. Sacchettini; William R. Jacobs Jr.

  Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl- acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis

  Journal of Bacteriology. 2000;182(14):4059-4067.
  127

• 180.

  2000

  Laurent Kremer; James D. Douglas; Alain R. Baulard; Caroline Morehouse; Mark R. Guy; David Alland; Lynn G. Dover; Jeremy H. Lakey; William R. Jacobs Jr.; Patrick J. Brennan; et al.

  Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis

  Journal of Biological Chemistry. 2000;275(22):16857-16864.
  147

• 181.

  2000

  Miriam Braunstein; Thomas J. Griffin IV; Jordan I. Kriakov; Sarah T. Friedman; Nigel D. F. Grindley; William R. Jacobs Jr.

  Identification of genes encoding exported Mycobacterium tuberculosis proteins using a Tn552'phoA in vitro transposition system

  Journal of Bacteriology. 2000;182(10):2732-2740.
  35

• 182.

  2000

  Mary K. Hondalus; Stoyan Bardarov; Robert Russell; John Chan; William R. Jacobs Jr.; Barry R. Bloom

  Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis

  Infection and Immunity. 2000;68(5):2888-2898.
  148

• 183.

  2000

  David Alland; Andries J. Steyn; Torin Weisbrod; Kate Aldrich; William R. Jacobs Jr.

  Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition

  Journal of Bacteriology. 2000;182(7):1802-1811.
  40

• 184.

  2000

  P.F. Riska; W.R. Jacobs Jr; D. Alland

  Molecular determinants of drug resistance in tuberculosis

  International Journal of Tuberculosis and Lung Disease. 2000;4(2 SUPPL. 1):S4-S10.
  58

• 185.

  2000

  Michael S Glickman; Jeffery S Cox; William R Jacobs Jr.

  A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis

  Molecular Cell. 2000;5(4):717-727.
  316

• 186.

  2000

  José Mediavilla; Shruti Jain; Jordon Kriakov; Michael E. Ford; Robert L. Duda; William R. Jacobs Jr.; Roger W. Hendrix; Graham F. Hatfull

  Genome organization and characterization of mycobacteriophage Bxb1

  Molecular Microbiology. 2000;38(5):955-970.
  48

• 187.

  2000

  Mark A. Chambers; Ann Williams; Dolores Gavier-Widén; Adam Whelan; Graham Hall; Philip D. Marsh; Barry R. Bloom; William R. Jacobs; R. Glyn Hewinson

  Identification of a Mycobacterium bovis BCG auxotrophic mutant that protects guinea pigs against M. bovis and Hematogenous spread of Mycobacterium tuberculosis without sensitization to tuberculin

  Infection and Immunity. 2000;68(12):7094-7099.
  43

• 188.

  2000

  Amy S. Piatek; Amalio Telenti; Megan R. Murray; Hiyam El-Hajj; William R. Jacobs Jr.; Fred Russell Kramer; David Alland

  Genotypic analysis of Mycobacterium tuberculosis in two distinct populations using molecular beacons: Implications for rapid susceptibility testing

  Antimicrobial Agents and Chemotherapy. 2000;44(1):103-110.
  144

• 189.

  1999

  Jeffery S. Cox; Bing Chess; Michael McNeil; William R. Jacobs Jr.

  Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

  Nature. 1999;402(6757):79-83.
  382

• 190.

  1999

  Martin S. Pavelka Jr.; William R. Jacobs Jr.

  Comparison of the construction of unmarked deletion mutations in Mycobacterium smegmatis, Mycobacterium bovis bacillus Calmette-Guerin, and Mycobacterium tuberculosis H37RV by allelic exchange

  Journal of Bacteriology. 1999;181(16):4780-4789.
  100

• 191.

  1999

  F.-C. Bange; F.M. Collins; W.R. Jacobs

  Survival of mice infected with Mycobacterium smegmatis containing large DNA fragments from Mycobacterium tuberculosis

  Tubercle and Lung Disease. 1999;79(3):171-180.
  39

• 192.

  1999

  Olivier Dussurget; Juliano Timm; Manuel Gomez; Benjamin Gold; Shengwei Yu; Sue Z. Sabol; Randall K. Holmes; William R. Jacobs Jr.; Issar Smith

  Transcriptional control of the iron-responsive fxbA gene by the mycobacterial regulator IdeR

  Journal of Bacteriology. 1999;181(11):3402-3408.
  60

• 193.

  1999

  Sabine Daugelat; William R. Jacobs Jr.

  The Mycobacterium tuberculosis recA intein can be used in an ORFTRAP to select for open reading frames

  Protein Science. 1999;8(3):644-653.
  19

• 194.

  1999

  Paul F. Riska; Ya Su; Svetoslav Bardarov; Lawrence Freundlich; Gary Sarkis; Graham Hatfull; Christian Carrière; Vanaja Kumar; John Chan; William R. Jacobs Jr.

  Rapid film-based determination of antibiotic susceptibilities of Mycobacterium tuberculosis strains by using a luciferase reporter phage and the Bronx Box

  Journal of Clinical Microbiology. 1999;37(4):1144-1149.
  56

• 195.

  1998

  David Alland; Igor Kramnik; Torin R. Weisbrod; Lisa Otsubo; Rosaria Cerny; Lincoln P. Miller; William R. Jacobs Jr.; Barry R. Bloom

  Identification of differentially expressed mRNA in prokaryotic organisms by customized amplification libraries (DECAL): The effect of isoniazid on gene expression in Mycobacterium tuberculosis

  Proceedings of the National Academy of Sciences of the United States of America. 1998;95(22):13227-13232.
  64

• 196.

  1998

  Asesh Banerjee; Michele Sugantino; James C. Sacchettini; William R. Jacobs Jr.

  The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance

  Microbiology. 1998;144(10):2697-2704.
  48

• 197.

  1998

  Shengwei Yu; Ellen Fiss; William R. Jacobs Jr.

  Analysis of the exochelin locus in Mycobacterium smegmatis: Biosynthesis genes have homology with genes of the peptide synthetase family

  Journal of Bacteriology. 1998;180(17):4676-4685.
  37

• 198.

  1998

  Lynn Miesel; Torin R. Weisbrod; Jovita A. Marcinkeviciene; Robert Bittman; William R. Jacobs Jr.

  NADH dehydrogenase defects confer isoniazid resistance and conditional- lethality in Mycobacterium smegmatis

  Journal of Bacteriology. 1998;180(9):2459-2467.
  75

• 199.

  1998

  Denise A. Rozwarski; Gregory A. Grant; Derek H. R. Barton; William R. Jacobs Jr.; James C. Sacchettini

  Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis

  Science. 1998;279(5347):98-102.
  345

• 200.

  1998

  P.F. Riska; W.R. Jacobs Jr.

  The use of luciferase-reporter phage for antibiotic-susceptibility testing of mycobacteria.

  Methods in molecular biology (Clifton, N.J.). 1998;101:431-455.
  18

• 201.

  1998

  Lynn Miesel; Denise A. Rozwarski; James C. Sacchettini; William R. Jacobs Jr.

  Mechanisms for isoniazid action and resistance

  Novartis Foundation Symposium. 1998;(217):209-221.
  21

• 202.

  1998

  Thomas Klabunde; Sujata Sharma; Amalio Telenti; William R. Jacobs Jr.; James C. Sacchettini

  Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing

  Nature Structural Biology. 1998;5(1):31-36.
  143

• 203.

  1998

  Luiz A. Basso; Renjian Zheng; James M. Musser; William R. Jacobs Jr.; John S. Blanchard

  Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: Enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates

  Journal of Infectious Diseases. 1998;178(3):769-775.
  76

• 204.

  1997

  Paul F. Riska; William R. Jacobs Jr.; Barry R. Bloom; John Mckitrick; John Chan

  Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: Use of p-nitro-α-acetylamino-β- hydroxy propiophenone

  Journal of Clinical Microbiology. 1997;35(12):3225-3231.
  31

• 205.

  1997

  Christian Carrière; Paul F. Riska; Oren Zimhony; Jordan Kriakov; Stoyan Bardarov; Judah Burns; John Chan; William R. Jacobs Jr.

  Conditionally replicating luciferase reporter phages: Improved sensitivity for rapid detection and assessment of drug susceptibility of Mycobacterium tuberculosis

  Journal of Clinical Microbiology. 1997;35(12):3232-3239.
  57

• 206.

  1997

  Amalio Telenti; Maurice Southworth; Fernando Alcaide; Sabine Daugelat; William R. Jacobs Jr.; Francine B. Perler

  The Mycobacterium xenopi GyrA protein splicing element: Characterization of a minimal intein

  Journal of Bacteriology. 1997;179(20):6378-6382.
  83

• 207.

  1997

  Vladimir Pelicic; Mary Jackson; Jean-Marc Reyrat; William R. Jacobs Jr.; Brigitte Gicquel; Christophe Guilhot

  Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis

  Proceedings of the National Academy of Sciences of the United States of America. 1997;94(20):10955-10960.
  288

• 208.

  1997

  Stoyan Bardarov; Jordan Kriakov; Christian Carriere; Shengwei Yu; Carlos Vaamonde; Ruth A. Mcadam; Barry R. Bloom; Graham F. Hatfull; William R. Jacobs Jr.

  Conditionally replicating mycobacteriophages: A system for transposon delivery to Mycobacterium tuberculosis

  Proceedings of the National Academy of Sciences of the United States of America. 1997;94(20):10961-10966.
  154

• 209.

  1997

  Srinand Sreevatsan; Kathryn E. Stockbauer; Xi Pan; Barry N. Kreiswirth; Soraya L. Moghazeh; William R. Jacobs Jr.; Amalio Telenti; James M. Musser

  Ethambutol resistance in Mycobacterium tuberculosis: Critical role of embB mutations

  Antimicrobial Agents and Chemotherapy. 1997;41(8):1677-1681.
  149

• 210.

  1997

  Amalio Telenti; Wolfgang J. Philipp; Srinand Sreevatsan; Claudia Bernasconi; Kathryn E. Stockbauer; Brigitte Wieles; James M. Musser; William R. Jacobs Jr.

  The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol

  Nature Medicine. 1997;3(5):567-570.
  191

• 211.

  1997

  David Tuckman; Robert J. Donnelly; Feng X. Zhao; William R. Jacobs Jr.; Nancy D. Connell

  Interruption of the phosphoglucose isomerase gene results in glucose auxotrophy in Mycobacterium smegmatis

  Journal of Bacteriology. 1997;179(8):2724-2730.
  8

• 212.

  1997

  Martin S. Pavelka Jr.; Torin R. Weisbrod; William R. Jacobs Jr.

  Cloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosis

  Journal of Bacteriology. 1997;179(8):2777-2782.
  14

• 213.

  1996

  Eugenie Dubnau; Sonia Soares; Tian Jun Huang; William R. Jacobs Jr.

  Overproduction of mycobacterial ribosomal protein S13 induces catalase/peroxidase activity and hypersensitivity to isoniazid in Mycobacterium smegmatis

  Gene. 1996;170(1):17-22.
  8

• 214.

  1996

  Wolfgang J. Philipp; Sylvie Poulet; Karin Eiglmeier; Lisa Pascopella; V. Balasubramanian; Beate Heym; Staffan Bergh; Barry R. Bloom; William R. Jacobs Jr.; et al.

  An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae

  Proceedings of the National Academy of Sciences of the United States of America. 1996;93(7):3132-3137.
  211

• 215.

  1996

  H.E. Takiff; M. Cimino; M.C. Musso; T. Weisbrod; R. Martinez; M.B. Delgado; L. Salazar; B.R. Bloom; W.R. Jacobs Jr.

  Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis

  Proceedings of the National Academy of Sciences of the United States of America. 1996;93(1):362-366.
  125

• 216.

  1996

  R.G. Hewinson; S.Ll. Michell; W.P. Russell; R.A. Mcadam; W.R. Jacobs Jr.

  Molecular characterization of MPT83: A seroreactive antigen of mycobacterium tuberculosis with homology to MPT70

  Scandinavian Journal of Immunology. 1996;43(5):490-499.
  90

• 217.

  1996

  Indira Guleria; Rachel Teitelbaum; Ruth A. McAdam; Ganjam Kalpana; William R. Jacobs Jr.; Barry R. Bloom

  Auxotrophic vaccines for tuberculosis

  Nature Medicine. 1996;2(3):334-337.
  128

• 218.

  1996

  V. Balasubramanian; Martin S. Pavelka Jr.; Stoyan S. Bardarov; Jean Martin; Torin R. Weisbrod; Ruth A. Mcadam; Barry R. Bloom; William R. Jacobs Jr.

  Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates

  Journal of Bacteriology. 1996;178(1):273-279.
  103

• 219.

  1996

  Martin S. Pavelka Jr.; William R. Jacobs Jr.

  Biosynthesis of diaminopimelate, the precursor of lysine and a component of peptidoglycan, is an essential function of Mycobacterium smegmatis

  Journal of Bacteriology. 1996;178(22):6496-6507.
  82

• 220.

  1996

  William R. Jacobs Jr.

  Science for combatting tuberculosis

  Bulletin of the New York Academy of Medicine: Journal of Urban Health. 1996;73(1):46-52.
  0

• 221.

  1996

  Robert E. Pearson; Stewart Jurgensen; Gary J. Sarkis; Graham F. Hatfull; William R. Jacobs Jr.

  Construction of D29 shuttle phasmids and luciferase reporter phages for detection of mycobacteria

  Gene. 1996;183(1-2):129-136.
  27

• 222.

  1996

  W. Jacobs; P. Brennan; G. Curlin; A. Ginsberg; M. Adams; R. Fleischman; C. Fraser; J.C. Venter; T. Shinnick; et al.

  Comparative sequencing [1]

  Science. 1996;274(5284):17-18.
  7

• 223.

  1996

  Franz-Christoph Bange; Amanda M. Brown; William R. Jacobs Jr.

  Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages

  Infection and Immunity. 1996;64(5):1794-1799.
  79

• 224.

  1995

  Desmond M. Collins; R. Pamela Kawakami; Geoffrey W. De Lisle; Lisa Pascopella; Barry R. Bloom; William R. Jacobs Jr.

  Mutation of the principal σ factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex

  Proceedings of the National Academy of Sciences of the United States of America. 1995;92(17):8036-8040.
  92

• 225.

  1995

  R.A. McAdam; T.R. Weisbrod; J. Martin; J.D. Scuderi; A.M. Brown; J.D. Cirillo; B.R. Bloom; W.R. Jacobs Jr.

  In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis

  Infection and Immunity. 1995;63(3):1004-1012.
  133

• 226.

  1995

  G.J. Sarkis; W.R. Jacobs Jr.; G.F. Hatfull

  L5 luciferase reporter mycobacteriophages: A sensitive tool for the detection and assay of live mycobacteria

  Molecular Microbiology. 1995;15(6):1055-1067.
  69

• 227.

  1995

  A. Dessen; A. Quemard; J.S. Blanchard; W.R. Jacobs Jr.; J.C. Sacchettin

  Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

  Science. 1995;267(5204):1638-1641.
  245

• 228.

  1995

  J.D. Cirillo; C.K. Stover; B.R. Bloom; W.R. Jacobs Jr.; R.G. Barletta

  Bacterial vaccine vectors and bacillus Calmette-Guerin

  Clinical Infectious Diseases. 1995;20(4):1001-1009.
  31

• 229.

  1994

  Ellen H. Fiss; Shengwei Yu; William R. Jacobs Jr.

  Identification of genes involved in the sequestration of iron in mycobacteria: The ferric exochelin biosynthetic and uptake pathways

  Molecular Microbiology. 1994;14(3):557-569.
  55

• 230.

  1994

  Jeffrey D. Cirillo; Torin R. Weisbrod; Lisa Pascopella; Barry R. Bloom; William R. Jacobs Jr.

  Isolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteria

  Molecular Microbiology. 1994;11(4):629-639.
  44

• 231.

  1994

  Asesh Banerjee; Eugenie Dubnau; Annaik Quemard; V. Balasubramanian; Kyung Sun Um; Theresa Wilson; Des Collins; Geoffrey De Lisle; William R. Jacobs Jr.

  inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

  Science. 1994;263(5144):227-230.
  664

• 232.

  1994

  J.A. Mills; M.R. McNeil; J.T. Belisle; W.R. Jacobs Jr.; P.J. Brennan

  Loci of Mycobacterium avium ser2 gene cluster and their functions

  Journal of Bacteriology. 1994;176(16):4803-4808.
  24

• 233.

  1994

  J.D. Cirillo; T.R. Weisbrod; A. Banerjee; B.R. Bloom; W.R. Jacobs Jr.

  Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria

  Journal of Bacteriology. 1994;176(14):4424-4429.
  19

• 234.

  1994

  N.M.W. Brunhuber; A. Banerjee; W.R. Jacobs; J.S. Blanchard

  Cloning, sequencing, and expression of Rhodococcus L-phenylalanine dehydrogenase. Sequence comparisons to amino-acid dehydrogenases

  Journal of Biological Chemistry. 1994;269(23):16203-16211.
  11

• 235.

  1994

  L. Pascopella; F.M. Collins; J.M. Martin; Mong Hong Lee; G.F. Hatfull; C.K. Stover; B.R. Bloom; W.R. Jacobs Jr.

  Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence

  Infection and Immunity. 1994;62(4):1313-1319.
  71

• 236.

  1994

  Beate Heym; Nadine Honoré; Chantal Truffot-Pernot; Asesh Banerjee; Catherine Schurra; William R. Jacobs Jr.; Jan D. A. Van Embden; Jacques H. Grosset; Stewart T. Cole

  Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: A molecular study

  Lancet. 1994;344(8918):293-298.
  202

• 237.

  1994

  B.R. Bloom; W.R. Jacobs Jr.; J.E. Clark-Curtiss

  Leprosy vaccine [3]

  Nature. 1994;368(6472):579.
  0

• 238.

  1993

  L.E. Averill; U. Cavallo; R.S. Wallis; W.H. Boom; M. Bona; M. Mincek; L. Pascopella; W.R. Jacobs Jr.; J.J. Ellner

  Screening of a cosmid library of Mycobacterium bovis BCG in Mycobacterium smegmatis for novel T-cell stimulatory antigens

  Research in Microbiology. 1993;144(5):349-362.
  8

• 239.

  1993

  W.R. Jacobs Jr.; R.G. Barletta; R. Udani; J. Chan; G. Kalkut; G. Sosne; T. Kieser; G.J. Sarkis; G.F. Hatfull; B.R. Bloom

  Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages

  Science. 1993;260(5109):819-822.
  226

• 240.

  1993

  J.J. Ellner; A.R. Hinman; S.W. Dooley; M.A. Fischl; K.A. Sepkowitz; M.J. Goldberger; T.M. Shinnick; M.D. Iseman; W.R. Jacobs Jr.

  Tuberculosis symposium: Emerging problems and promise

  Journal of Infectious Diseases. 1993;168(3):537-551.
  72

• 241.

  1993

  J.T. Belisle; K. Klaczkiewicz; P.J. Brennan; W.R. Jacobs Jr.; J.M. Inamine

  Rough morphological variants of Mycobacterium avium. Characterization of genomic deletions resulting in the loss of glycopeptidolipid expression

  Journal of Biological Chemistry. 1993;268(14):10517-10523.
  52

• 242.

  1993

  M.K. Donnelly-Wu; W.R. Jacobs Jr.; G.F. Hatfull

  Superinfection immunity of mycobacteriophage L5: Applications for genetic transformation of mycobacteria

  Molecular Microbiology. 1993;7(3):407-417.
  65

• 243.

  1993

  L. Pascopella; F.M. Collins; J.M. Martin; W.R. Jacobs Jr.; B.R. Bloom

  Identification of a genomic fragment of Mycobacterium tuberculosis responsible for in vivo growth advantage

  Infectious Agents and Disease. 1993;2(4):282-284.
  7

• 244.

  1992

  W.R. Jacobs Jr.

  Advances in mycobacterial genetics: New promises for old diseases

  Immunobiology. 1992;184(2-3):147-156.
  13

• 245.

  1992

  R.G. Barletta; D.D. Kim; S.B. Snapper; B.R. Bloom; W.R. Jacobs Jr.

  Identification of expression signals of the mycobacteriophages Bxb1, L1 and TM4 using the Escherichia-Mycobacterium shuttle plasmids pYUB75 and pYUB76 designed to create translational fusions to the lacZ gene

  Journal of General Microbiology. 1992;138(1):23-30.
  26

• 246.

  1992

  C.K. Stover; V.F. De la Cruz; G.P. Bansal; M.S. Hanson; T.R. Fuerst; W.R. Jacobs Jr.; B.R. Bloom

  Use of recombinant BCG as a vaccine delivery vehicle

  Advances in Experimental Medicine and Biology. 1992;327:175-182.
  18

• 247.

  1991

  C.K. Stover; V.F. De La Cruz; T.R. Fuerst; J.E. Burlein; L.A. Benson; L.T. Bennett; G.P. Bansal; J.F. Young; M.H. Lee; G.F. Hatfull; et al.

  New use of BCG for recombinant vaccines

  Nature. 1991;351(6326):456-460.
  661

• 248.

  1991

  Mong Hong Lee; L. Pascopella; W.R. Jacobs Jr.; G.F. Hatfull

  Site-specific integration of mycobacteriophage L5: Integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guerin

  Proceedings of the National Academy of Sciences of the United States of America. 1991;88(8):3111-3115.
  193

• 249.

  1991

  C.L. Daley; P.M. Small; G.F. Schecter; G.K. Schoolnik; R.A. McAdam; W.R. Jacobs Jr.; P.C. Hopewell

  An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus: An analysis using restriction-fragment-length polymorphisms

  New England Journal of Medicine. 1991;326(4):231-235.
  546

• 250.

  1991

  G.V. Kalpana; B.R. Bloom; W.R. Jacobs Jr.

  Insertional mutagenesis and illegitimate recombination in mycobacteria

  Proceedings of the National Academy of Sciences of the United States of America. 1991;88(12):5433-5437.
  74

• 251.

  1991

  Worachart Sirawaraporn; Rachada Sirawaraporn; Atid Chanpongsri; William R. Jacobs Jr.; Daniel V. Santi

  Purification and characterization of dihydrofolate reductase from wild-type and trimethoprim-resistant Mycobacterium smegmatis

  Experimental Parasitology. 1991;72(2):184-190.
  5

• 252.

  1991

  J.D. Cirillo; R.G. Barletta; B.R. Bloom; W.R. Jacobs Jr.

  A novel transposon trap for mycobacteria: Isolation and characterization of IS1096

  Journal of Bacteriology. 1991;173(24):7772-7780.
  54

• 253.

  1991

  W.R. Jacobs Jr.; G.V. Kalpana; J.D. Cirillo; L. Pascopella; S.B. Snapper; R.A. Udani; W. Jones; R.G. Barletta; B.R. Bloom

  Genetic systems for mycobacteria.

  Methods in Enzymology. 1991;204:537-555.
  294

• 254.

  1991

  J.T. Belisle; L. Pascopella; J.M. Inamine; P.J. Brennan; W.R. Jacobs Jr.

  Isolation and expression of a gene cluster responsible for biosynthesis of the glycopeptidolipid antigens of Mycobacterium avium

  Journal of Bacteriology. 1991;173(21):6991-6997.
  39

• 255.

  1990

  S.B. Snapper; R.E. Melton; S. Mustafa; T. Kieser; W.R. Jacobs Jr.

  Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis

  Molecular Microbiology. 1990;4(11):1911-1919.
  567

• 256.

  1990

  W.R. Jacobs Jr.; S.B. Snapper; L. Lugosi; B.R. Bloom

  Development of BCG as a recombinant vaccine vehicle

  Current Topics in Microbiology and Immunology. 1990;155:153-160.
  19

• 257.

  1990

  R.G. Barletta; B. Snapper; J.D. Cirillo; N.D. Connell; D.D. Kim; W.R. Jacobs; B.R. Bloom

  Recombinant BCG as a candidate oral vaccine vector

  Research in Microbiology. 1990;141(7-8):931-939.
  25

• 258.

  1989

  W.R. Jacobs Jr.; S.B. Snapper; M. Tuckman; B.R. Bloom

  Mycobacteriophage vector systems.

  Reviews of Infectious Diseases. 1989;11 Suppl 2:S404-410.
  12

• 259.

  1989

  B.R. Bloom; W.R. Jacobs Jr.

  New strategies for leprosy and tuberculosis and for development of bacillus Calmette-Guerin into a multivaccine vehicle

  Annals of the New York Academy of Sciences. 1989;569:155-173.
  4

• 260.

  1989

  L. Lugosi; W.R. Jacobs Jr.; B.R. Bloom

  Genetic transformation of BCG

  Tubercle. 1989;70(3):159-170.
  6

• 261.

  1989

  W.R. Jacobs Jr.; S.B. Snapper; L. Lugosi; A. Jekkel; R.E. Melton; T. Kieser; B.R. Bloom

  Development of genetic systems for the mycobacteria

  Acta Leprologica. 1989;7(SUPPL. 1):203-207.
  4

• 262.

  1989

  L. Lugosi; W. Jacobs; B.R. Bloom

  Transformation of BCG with plasmid DNA

  Acta Leprologica. 1989;7(SUPPL. 1):256-257.
  4

• 263.

  1989

  C.M. Grosskinsky; W.R. Jacobs Jr.; J.E. Clark-Curtiss; B.R. Bloom

  Genetic relationships among Mycobacterium leprae, Mycobacterium tuberculosis, and candidate leprosy vaccine strains determined by DNA hybridization: Identification of an M. leprae-specific repetitive sequence

  Infection and Immunity. 1989;57(5):1535-1541.
  11

• 264.

  1988

  S.B. Snapper; L. Lugosi; A. Jekkel; R.E. Melton; T. Kieser; B.R. Bloom; W.R. Jacobs Jr.

  Lysogeny and transformation in mycobacteria: Stable expression of foreign genes

  Proceedings of the National Academy of Sciences of the United States of America. 1988;85(18):6987-6991.
  114

• 265.

  1987

  W.R. Jacobs Jr.; M. Tuckman; B.R. Bloom

  Introduction of foreign DNA into mycobacteria using a shuttle phasmid

  Nature. 1987;327(6122):532-535.
  83

• 266.

  1986

  W.R. Jacobs; J.F. Barrett; J.E. Clark-Curtiss; R. Curtiss III

  In vivo repackaging of recombinant cosmid molecules for analyses of Salmonella typhimurium, Streptococcus mutans, and mycobacterial genomic libraries

  Infection and Immunity. 1986;52(1):101-109.
  18

• 267.

  1986

  W.R. Jacobs; M.A. Docherty; R. Curtiss III; J.E. Clark-Curtiss

  Expression of Mycobacterium leprae genes from a Streptococcus mutans promoter in Escherichia coli K-12

  Proceedings of the National Academy of Sciences of the United States of America. 1986;83(6):1926-1930.
  7

• 268.

  1985

  J.E. Clark-Curtiss; W.R. Jacobs; M.A. Docherty; L.R. Ritchie

  Molecular analysis of DNA and construction of genomic libraries of Mycobacterium leprae

  Journal of Bacteriology. 1985;161(3):1093-1102.
  31