Wencheng Xiong

Medicine, Neurology

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Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons

Yu Liu; Yan-Mei Tao; Ran-Sook Woo; Wen-Cheng Xiong; Lin Mei (Profiled Authors: Lin Mei; Wencheng Xiong)

Biochemical and Biophysical Research Communications. 2007;354(2):505-510.

Neuregulin-1 (NRG1) plays an important role in neural development, synapse formation, and synaptic plasticity by activating ErbB receptor tyrosine kinases. Although ligand-induced endocytosis has been shown to be important for many receptor tyrosine kinases, whether NRG1 signaling depends on ErbB endocytosis remains controversial. Here, we provide evidence that ErbB4, a prominent ErbB protein in the brain, becomes internalized in NRG1-stimulated neurons. The induced ErbB4 endocytosis requires its kinase activity. Remarkably, inhibition of ErbB endocytosis attenuates NRG1-induced activation of Erk and Akt in neurons. These observations indicate a role of ErbB endocytosis in NRG1 signaling in neurons. © 2007 Elsevier Inc. All rights reserved.

PMID: 17250808     PMCID: PMC2696396

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