Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Journal of Biological Chemistry. 2003;278(2):1108-1114.Abstract
We present evidence here that Erbin is a negative regulator of the Ras-Raf-Erk signaling pathway. Expression of Erbin decreases transcription of the AChR ε-subunit gene, an event that is mediated by Erk activation. Although it interacts with the ErbB2 C terminus through the PDZ domain, Erbin has no effect on ErbB2 tyrosine phosphorylation or binding to the adaptor proteins Shc and Grb2. In contrast, expression of Erbin greatly impairs activation of Erk, but not Akt, by ligands that activate receptor tyrosine kinases. Moreover, Erbin inhibits the Erk activation by active Ras, while it fails to do so in the presence of active Raf-1. Erbin associates with active Ras, but not inactive Ras nor Raf. Consistently, Erbin interferes with the interaction between Ras and Raf both in vivo and in vitro. Finally, overexpression of Erbin leads to inhibition of NGF-induced neuronal differentiation of PC12 cells, whereas downregulation of endogenous Erbin by specific siRNA exhibits an opposite effect. Collectively, our study has identified Erbin as a novel suppressor of the Ras signaling by disrupting the Ras-Raf interaction.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Bo-Shiun Chen; Zu-Wen Sun; Michael HampseyJournal of Biological Chemistry. 2001;276(26):23881-23887.
Pascaline Gaildrat; Morten Møller; Sujira Mukda; Ann Humphries; David A. Carter; Vadivel Ganapathy; David C. KleinJournal of Biological Chemistry. 2005;280(17):16851-16860.
Guoqing Hu; Xiaobo Wang; Darren N. Saunders; Michelle Henderson; Amanda J. Russell; B. Paul Herring; Jiliang ZhouJournal of Biological Chemistry. 2010;285(16):11800-11809.
Appears in this Document