Wencheng Xiong

Medicine, Neurology

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β-catenin interacts with MyoD and regulates its transcription activity

Chang-Hoon Kim; Hannah Neiswender; Joo Baik Eun; Wen C. Xiong; Lin Mei (Profiled Authors: Lin Mei; Wencheng Xiong)

Molecular and Cellular Biology. 2008;28(9):2941-2951.

Wnt regulation of muscle development is thought to be mediated by the β-catenin-TCF/LEF-dependent canonical pathway. Here we demonstrate that β-catenin, not TCF/LEF, is required for muscle differentiation. We showed that β-catenin interacts directly with MyoD, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to E box elements and transcriptional activity. MyoD-mediated transactivation is inhibited in muscle cells when β-catenin is deficient or the interaction between MyoD and β-catenin is disrupted. These results demonstrate that β-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway. Copyright © 2008, American Society for Microbiology. All Rights Reserved.

PMID: 18316399     PMCID: PMC2293083

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