Paul L McNeil

Medicine, Cellular Biology and Anatomy

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Receptor for Advanced Glycation End products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a β-catenin-dependent manner

Fei Xiong; Sergey Leonov; Amber Cyan Howard; Shan Xiong; Bin Zhang; Lin Mei; Paul McNeil; Sylvia Simon; Wen-Cheng Xiong (Profiled Authors: Paul L McNeil; Bin Zhang; Lin Mei; Wencheng Xiong)

Journal of Biological Chemistry. 2011;286(40):35061-35070.

Background: RAGE contributes to the vascular pathology associated with multiple disorders, including Alzheimer disease (AD), diabetic complications, and inflammatory conditions. However, the underlying mechanisms remain largely unknown. Results: RAGE expression in endothelial cells leads to an impaired plasma membrane resealing, altered F-actin remodeling, and increased β-catenin level. Conclusion: Throughβ-catenin, RAGE decreases F-actin stress fibers and prevents endothelial membrane repair in response to the injury. Significance: These results suggest a negative role of RAGE in membrane repair, reveal a new mechanism underlying RAGE regulation of F-actin remodeling, and help our understanding of RAGE involvement in AD and diabetic complication-associated vascular pathology. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

PMID: 21844192     PMCID: PMC3186364

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