Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells
Andrea Balogh; Eszter Persa; Eniko Noémi Bogdándi; Anett Benedek; Hargita Hegyesi; Géza Sáfrány; Katalin Lumniczky(Profiled Authors: H. Hegyesi; G. Sáfrány)
Inflammation Research. 2013;62(2):201-212.Abstract
Objective: Radiotherapy affects antitumor immune responses; therefore, it is important to study radiation effects on various compartments of the immune system. Here we report radiation effects on the homeostasis and function of regulatory T (Treg) cells, which are important in down-regulating antitumor immune responses. Methods: C57Bl/6 mice were irradiated with 2 Gy and alterations in splenic lymphocyte fractions analyzed at different intervals. Results: Total CD4+ numbers showed stronger decrease after irradiation than CD4+Foxp3+ Tregs. Tregs were less prone to radiation-induced apoptosis than CD4+Foxp3- T cells. The ratio of CD4+Foxp3- and CD4+Foxp3+ fractions within the proliferating CD4+ pool progressively changed from 74:26 in control animals to 59:41 eleven days after irradiation, demonstrating a more dynamic increase in the proliferation and regeneration of the Treg pool. The CD4+Foxp3+ fraction expressing cell-surface CTLA4, an antigen associated with Treg cell activation increased from 5.3 % in unirradiated mice to 10.5 % three days after irradiation. The expression of IL-10 mRNA was moderately upregulated, while TGF-β expression was not affected. On the other hand, irradiation reduced Treg capacity to suppress effector T cell proliferation by 2.5-fold. Conclusion: Tregs are more radioresistant, less prone to radiation-induced apoptosis, and have faster repopulation kinetics than CD4+Foxp3- cells, but irradiated Tregs are functionally compromised, having a reduced suppressive capacity. © 2012 Springer Basel.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Enikö Noémi Bogdándi; Andrea Balogh; Nikolett Felgyinszki; Tünde Szatmári; Eszter Persa; Guido Hildebrandt; Géza Sáfrány; Katalin LumniczkyRadiation Research. 2010;174(4):480-489.
Gergely Toldi; Peter Švec; Barna Vásárhelyi; Gergo Mészáros; János Rigó; Tivadar Tulassay; András TreszlActa Obstetricia et Gynecologica Scandinavica. 2008;87(11):1229-1233.
Hideaki Sugiyama; Rolland Gyulai; Eiko Toichi; Edina Garaczi; Shinji Shimada; Seth R. Stevens; Thomas S. McCormick; Kevin D. CooperJournal of Immunology. 2005;174(1):164-173.
Appears in this Document