Kristine M. Mosier

School of Medicine, Radiology & Imaging Sciences

Scopus Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.

Target volume uncertainty and a method to visualize its effect on the target dose prescription

Traci McCormick; Delal Dink; Seza Orcun; Joseph Pekny; Ron Rardin; Larry Baxter; Van Thai; Mark Langer (Profiled Author: Mark P. Langer)

International Journal of Radiation Oncology Biology Physics. 2004;60(5):1580-1588.

To consider the uncertainty in the construction of target boundaries for optimization, and to demonstrate how the principles of mathematical programming can be applied to determine and display the effect on the tumor dose of making small changes to the target boundary. The effect on the achievable target dose of making successive small shifts to the target boundary within its range of uncertainty was found by constructing a mixed-integer linear program that automated the placement of the beam angles using the initial target volume. The method was demonstrated using contours taken from a nasopharynx case, with dose limits placed on surrounding structures. In the illustrated case, enlarging the target anteriorly to provide greater assurance of disease coverage did not force a sacrifice in the minimum or mean tumor doses. However, enlarging the margin posteriorly, near a critical structure, dramatically changed the minimum, mean, and maximum tumor doses. Tradeoffs between the position of the target boundary and the minimum target dose can be developed using mixed-integer programming, and the results projected as a guide to contouring and plan selection. © 2004 Elsevier Inc.

PMID: 15590190    

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.