G. David Roodman

School of Medicine, Medicine, Hematology/Oncology

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Osteoporosis with increased osteoclastogenesis in hematopoietic cell-specific STAT3-deficient mice

Zhiyuan Zhang; Thomas Welte; Nancy Troiano; Stephen E. Maher; Xin-Yuan Fu; Alfred L.M. Bothwell (Profiled Author: Xin-Yuan Fu)

Biochemical and Biophysical Research Communications. 2005;328(3):800-807.

Hematopoietic cell-specific disruption of the STAT3 gene induces hyperproliferation of cells of the myeloid lineage. Osteoclasts (OC), the bone-resorbing cells, are generated from the same precursors as monocyte/macrophages. STAT3 mutant mice exhibit decreased bone density, bone volume, and increased numbers of TRAP-positive OC. In vitro generation of OC showed significantly greater numbers of OC in mutant mice. The increased numbers of Mac1⁺ cells and c-kit⁺ cells were detected by FACS analysis, suggesting an increased number of OC precursors. Treatment of splenocytes with CSF-1 and RANKL significantly increased the Mac-1 ⁺RANK⁺ cells, with much higher levels observed in cells from mutant mice compared with littermate controls. Besides enhanced number of Mac1⁺ OC precursors, we also identified an OC-generating Mac1 ^- c-kit⁺ population in mutant mice which was absent in littermate controls. The Mac1^- c-kit^- cells did not generate OC. Finally, we determined that protein expression and mRNA level of c-fos, a transcription factor which is essential for OC differentiation, were enhanced in OC precursors of mutant mice, which may contribute to the osteopenic phenotype. © 2005 Elsevier Inc. All rights reserved.

PMID: 15694417    

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