Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Doxorubicin-induced ultrastructural and growth changes in primary cultures of 7,12-dimethylbenz[a]anthracene-induced mammary tumors
A.R. Safa; M.T. Tseng (Profiled Author: Ahmad R. Safa)
Journal of the National Cancer Institute. 1983;70(3):535-540.Abstract
For the determination of their response to doxorubicin (Dx) (adriamycin), monodispersed mammary tumor cells (from female outbred Sprague-Dawley rats) were maintained as monolayer primary culture. Dose-response curves and [3H]thymidine labeling indices showed the antimitotic and cytocidal effects of the drug varied in a dose-dependent fashion. Dose-response curves revealed that the median lethal dose concentration was 10-4 M. A 24-hour treatment at concentrations of 10-4 to 10-5 M completely arrested DNA synthesis of the tumor cells. Surviving cells exhibited chromatin abnormalities, accumulation of cytoplasmic myelin bodies, vacuolization of endoplasmic reticulum, and increased density of mitochondrial matrix. This study showed 1) 7,12-dimethylbenz[a]anthracene-induced mammary tumor cells were highly sensitive to Dx; 2) Dx induced specific ultrastructural effects on the nuclei, mitochondria, and membranes of the cells; and 3) the in vitro response of the primary culture may be useful for prediction of the response of the source tumor to chemotherapy.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
A.R. Safa; M.T. Tseng; R.J. BallouProceedings of the Society for Experimental Biology and Medicine. 1983;174(2):276-283.
M.T. Tseng; A.R. SafaCancer Detection and Prevention. 1983;6(3):371-379.
A.R. Safa; M.T. TsengJournal of Cell Biology. 1981;91(2 II):No.6045.
Appears in this Document