Scopus Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.

A role for class-II major histocompatibility complex antigens in the regulation of myelopoiesis

H.E. Broxmeyer; B. Dupont (Profiled Author: Hal E. Broxmeyer)

Progress in Allergy. 1985;VOL. 36:203-221.

Except for the genetic restriction studies, where the HLA class-II antigens are needed for communication between cells, it is not proven that the HLA class-II antigens on human cells and class-II antigens on mouse cells are needed for the actions of the iron-binding glycoproteins LF, TF and AIF. While it is clear that MHC class-II positive cells are targets for these suppressor molecules and that there is a very tight association between the presence of these antigens on the specific target cells and the action of these iron-binding glycoproteins, further studies are needed to determine what role, if any, the MHC class-II antigens may play in this regulatory interaction for myelopoiesis in vitro. It is clear that the presence of class-II antigens on the different target cells for LF, TF and AIF preclude the possibility that they are specific receptors for these molecules. In addition to class-II antigens, the target cells must have specific receptors for LF, TF, or AIF. The possibility exists that Ia antigens may be needed for movement of LF, TF and AIF into the cells and/or that they may serve as a messenger link between the triggering event on the cell surface and the actual mechanisms that lead eventually to the suppressive events noted. If class-II antigens are involved in the functional actions of LF, TF and AIF at the cell surface, it would indicate that Ia antigens might serve a role in addition to their functions as an antigen-presenting molecule. Alternatively, more precise separation of subpopulations of cells may demonstrate that the actions of LF, TF and AIF involve cell-cell interactions and that the class-II antigens are involved intimately in a molecule-cell-cell interaction.

PMID: 2578673    

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.