William J. McBride

School of Medicine, Psychiatry

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Genetic and neurobiological basis of alcohol-seeking behavior

T.-K. Li; L. Lumeng; W.J. McBride; J.M. Murphy (Profiled Authors: Lawrence Lumeng; William J. McBride)

Alcohol and Alcoholism. 1994;29(6):697-700.

Through selective breeding, rat lines exhibiting high and low alcohol drinking preference have been developed as useful animal models for studying the neurobiological basis of alcohol-seeking behavior. The identified differences between lines in neurotransmitter functioning allows the evaluation of receptor agonist/antagonist compounds that might be efficacious in the treatment of alcohol craving and dependence.

PMID: 7695786    

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