Pathology & Laboratory Medicine

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An assessment of the association of bispectral index with 2 clinical sedation scales for monitoring depth of procedural sedation

Christopher S. Weaver; William H. Hauter; Cory E. Duncan; Edward J. Brizendine; William H. Cordell (Profiled Author: Christopher S. Weaver)

American Journal of Emergency Medicine. 2007;25(8):918-924.

Objective: We conducted a study to assess the correlation of bispectral index (BIS) to 2 clinical sedation scales. Methods: This was a prospective, observational study. The BIS number was recorded at baseline and every 30 seconds. One investigator separately monitored the patients for depth of sedation using the Observer's Assessment of Alertness/Sedation and the Continuum of Depth of Sedation scales. Results: During the 6-month period, 75 patients were enrolled. The Spearman correlation between the BIS and the Observer's Assessment of Alertness/Sedation was 0.59 (95% confidence interval [CI], 0.44-0.74). The Spearman correlation between the BIS and the Continuum of Depth of Sedation was 0.53 (95% CI, 0.36-0.70). The mean minimum BIS for patients without a complication was 70 (SD, 15.9) compared with 68 (SD, 12.9) for patients with a complication (difference = 2; 95% CI, -7-11). Conclusions: Our study demonstrated moderate correlation between BIS and the 2 clinical sedation scales. The correlation is not strong enough to be used reliably in a clinical setting. The mean minimum BIS scores were not significantly different for those with sedation complications vs those without complications. © 2007 Elsevier Inc. All rights reserved.

PMID: 17920977    

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