Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons
Núria Morral; Wanda K. O'Neal; Karen Rice; M. Michelle Leland; Pedro A. Piedra; Estuardo Aguilar-Córdova; K. Dee Carey; Arthur L. Beaudet; Claire Langston (Profiled Author: Nuria Morral)
Human Gene Therapy. 2002;13(1):143-154.Abstract
The effects of intravenous administration of a first-generation adenoviral vector expressing β-galactosidase were compared in two baboons receiving a high dose or lower dose of vector, 1.2 × 10 13 or 1.2 × 10 12 particles/kg, respectively. The high-dose baboon developed acute symptoms, decreased platelet counts, and increased liver enzymes, and became moribund at 48 hr after injection, while the lower-dose baboon developed no symptoms. Expression of the β-galactosidase transgene was prominent in liver, spleen, and endothelium of the arterial vasculature in the high-dose baboon, but was much more limited and spared the endothelium in the lower-dose baboon. Injury to the vascular endothelium was the most prominent abnormality in the high-dose baboon. Extensive histological studies provide a detailed picture of the pathology associated with a lethal dose of first-generation adenoviral vector in a primate.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Keith L. March; Michael Woody; Khawar Mehdi; Douglas P. Zipes; Mark Brantly; Bruce C. TrapnellClinical Cardiology. 1999;22(1 SUPPL.):I23-I29.
Núria Morral; Wanda O'Neal; Heshan Zhou; Claire Langston; Arthur BeaudetHuman Gene Therapy. 1997;8(10):1275-1286.
Hayder H. Al-Azzawi; Kathryn M. Ziegler; Deborah A. Swartz-Basile; Sue Wang; Henry A. Pitt; Nicholas J. ZyromskiJournal of Gastrointestinal Surgery. 2011;15(8):1394-1400.
Appears in this Document