Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Proceedings of the National Academy of Sciences of the United States of America. 2002;99(22):14548-14553.Abstract
The cancer chemopreventive properties of selenium compounds are well documented, yet little is known of the mechanism(s) by which these agents inhibit carcinogenesis. We show that selenium in the form of selenomethionine (SeMet) can activate the p53 tumor suppressor protein by a redox mechanism that requires the redox factor Ref1. Assays to measure direct reduction/oxidation of p53 showed a SeMet-dependent response that was blocked by a dominant-negative Ref1. By using a peptide containing only p53 cysteine residues 275 and 277, we demonstrate the importance of these residues in the SeMet-induced response. SeMet induced sequence-specific DNA binding and transactivation by p53. Finally, cellular responses to SeMet were determined in mouse embryo fibroblasts wild-type or null for p53 genes. The evidence suggests that the DNA repair branch of the p53 pathway was activated. The central relevance of DNA repair to cancer prevention is discussed.
PMID: 12357032 PMCID: PMC137920
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Joshua L. Fischer; Jody K. Lancia; Anita Mathur; Martin L. SmithAnticancer Research. 2006;26(2 A):899-904.
Martin L. Smith; Jody K. Lancia; Timothy I. Mercer; C. IpAnticancer Research. 2004;24(3 A):1401-1408.
M.R. Kelley; L. Cheng; R. Foster; R. Tritt; J. Jiang; J. Broshears; M. KochClinical Cancer Research. 2001;7(4):824-830.
Appears in this Document