Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Rho GTPases show differential sensitivity to nucleotide triphosphate depletion in a model of ischemic cell injury
Mark A. Hallett; Pierre C. Dagher; Simon J. Atkinson (Profiled Author: Pierre C. Dagher)
American Journal of Physiology - Cell Physiology. 2003;285(1 54-1):C129-C138.Abstract
Rho GTPases are critical for actin cytoskeletal regulation, and alterations in their activity may contribute to altered cytoskeletal organization that characterizes many pathological conditions, including ischemia. G protein activity is a function of the ratio of GTP-bound (active) to GDP-bound (inactive) protein, but the effect of altered energy metabolism on Rho protein activity has not been determined. We used antimycin A and substrate depletion to induce depletion of intracellular ATP and GTP in the kidney proximal tubule cell line LLC-PK
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