Scopus Publication Detail
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Hydroxyitraconazole, formed during intestinal first-pass metabolism of itraconazole, controls the time course of hepatic CYP3A inhibition and the bioavailability of itraconazole in rats
Sara K. Quinney; Raymond E. Galinsky; Vanida A. Jiyamapa-Serna; Yong Chen; Mitchell A. Hamman; Stephen D. Hall; Robert E. Kimura (Profiled Author: Sara K. Quinney)
Drug Metabolism and Disposition. 2008;36(6):1097-1101.Abstract
Itraconazole (ITZ) is a substrate of CYP3A and both ITZ and hydroxyitraconazole (OH-ITZ), a major metabolite formed by CYP3A, are potent inhibitors of CYP3A. The concentration- and time-dependent changes in the hepatic availability (F
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