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ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation
Goro Sashida; Yan Liu; Shannon Elf; Yasuhiko Miyata; Kazuma Ohyashiki; Miki Izumi; Silvia Menendez; Stephen D. Nimer (Profiled Author: Yan Liu)
Molecular and Cellular Biology. 2009;29(13):3687-3699.Abstract
Several ETS transcription factors, including ELF4/MEF, can function as oncogenes in murine cancer models and are overexpressed in human cancer. We found that Elf4/Mef activates Mdm2 expression; thus, lack of or knockdown of Elf4/Mef reduces Mdm2 levels in mouse embryonic fibroblasts (mef's), leading to enhanced p53 protein accumulation and p53-dependent senescence. Even though p53 is absent in Elf4-/- p53-/- mef's, neither oncogenic H-Ras
PMID: 19380490 PMCID: PMC2698769
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