David A. Plager

School of Medicine, Ophthalmology

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A randomized clinical trial comparing contact lens with intraocular lens correction of monocular aphakia during infancy: Grating acuity and adverse events at age 1 year

Scott R. Lambert; Edward G. Buckley; Carolyn Drews-Botsch; Lindreth DuBois; E. Eugenie Hartmann; Michael J. Lynn; David A. Plager; M. Edward Wilson (Profiled Author: David A. Plager)

Archives of Ophthalmology. 2010;128(7):810-818.

Objective: To compare the visual outcomes and adverse events of contact lens with primary intraocular lens (IOL) correction of monocular aphakia during infancy. Methods: In a randomized, multicenter (12 sites) clinical trial, 114 infants with a unilateral congenital cataract were assigned to undergo cataract surgery between 1 to 6 months of age either with or without primary IOL implantation. Contact lenses were used to correct aphakia in patients who did not receive IOLs. Grating visual acuity was tested at 1 year of age by a masked traveling examiner. Main Outcome Measure: Grating visual acuity at 1 year of age. Results: The median logMAR visual acuity was not significantly different between the treated eyes in the 2 groups (contact lens group, 0.80; IOL group, 0.97; P=.19). More patients in the IOL group underwent 1 or more additional intraocular operations than patients in the contact lens group (63% vs 12%; P<.001). Most of these additional operations were performed to clear lens reproliferation and pupillary membranes from the visual axis. Conclusions: There was no statistically significant difference in grating visual acuity at age 1 year between the IOL and contact lens groups; however, additional intraocular operations were performed more frequently in the IOL group. Application to Clinical Practice: Until longer-term follow-up data are available, caution should be exercised when performing IOL implantation in children aged 6 months or younger given the higher incidence of adverse events and the absence of an improved short-term visual outcome compared with contact lens use. Trial Registration: clinicaltrials.gov Identifier: NCT00212134. ©2010 American Medical Association. All rights reserved.

PMID: 20457949    

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