Scopus Publication Detail
The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in Scopus. This abstract is what is used to create the fingerprint of the publication.
Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: Revised and updated results
Clinical Pharmacology and Therapeutics. 2010;88(5):626-629.Abstract
We previously reported that the ESR1 XbaI genotypes were associated with baseline and tamoxifen-induced serum lipid profiles. The analysis in that study was carried out by PCR followed by restriction-enzyme digestion. After reanalysis using more robust TaqMan assays, the findings related to ∼10% of the genotypes for the ESR1 XbaI single-nucleotide polymorphism (SNP) were revised. For the other genotypes (i.e., ESR1 PvuII, ESR2, and CYP2D6), the results were nearly identical to those in the previous study. Upon reanalysis, previously reported associations between the ESR1 Xba1 genotypes and baseline triglyceride and low-density lipoprotein (LDL) cholesterol levels were no longer observed. Previously reported associations between the ESR1 XbaI genotypes and tamoxifen-induced changes in levels of total cholesterol, triglycerides, and high-density lipoprotein (HDL) cholesterol were also no longer observed. However, the following observations from the original report did not change: (i) the levels of circulating lipids are lower in women taking tamoxifen; (ii) there is an association between the ESR2-02 genotypes and changes in triglyceride levels; and (iii) neither ESR1 PvuII nor CYP2D6 is associated with any changes in serum lipid concentrations in patients receiving treatment with tamoxifen.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
N.I. Ntukidem; A.T. Nguyen; V. Stearns; M. Rehman; A. Schott; T. Skaar; Y. Jin; P. Blanche; L. Li; S. Lemler; et al.Clinical Pharmacology and Therapeutics. 2008;83(5):702-710.
Toni I. Pollin; Tamara Isakova; Kathleen A. Jablonski; Paul I. W. de Bakker; Andrew Taylor; Jarred McAteer; Qing Pan; Edward S. Horton; Linda M. Delahanty; David Altshuler; et al.PLoS Genetics. 2012;8(8).
N.L. Henry; A. Nguyen; F. Azzouz; L. Li; J. Robarge; S. Philips; D. Cao; T.C. Skaar; J.M. Rae; A.M. Storniolo; et al.British Journal of Cancer. 2010;102(2):294-300.
Appears in this Document