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Karmen K. Yoder; Daniel S. Albrecht; David A. Kareken; Lauren M. Federici; Kevin M. Perry; Elizabeth A. Patton; Qi-Huang Zheng; Bruce H. Mock; Sean J. O'Connor; Christine M. Herring (Profiled Authors: David A. Kareken; Sean J. O'Connor; Karmen K. Yoder; Qi-Huang Zheng)
European Journal of Nuclear Medicine and Molecular Imaging. 2012;39(2):220-225.Abstract
Purpose: In studies where [ 11C]raclopride (RAC) positron emission tomography (PET) is used to assess changes in striatal dopamine, it is important to control for cognitive states, such as drug craving, that could alter dopamine levels. In cigarette smokers, transdermal nicotine patches (TNP) can control nicotine craving, but the effects of nicotine patches on RAC binding are unknown. Thus, we sought to determine the test-retest reliability of RAC binding in the presence of nicotine patches. Methods: Eleven male smokers were scanned twice with RAC on separate days while wearing TNP. Results: Across the striatum, test-retest variability was 7.63±5.88; percent change in binding potential was 1.11±9.83; and the intraclass correlation coefficient was 0.91 (p<0.0001). Conclusion: Baseline RAC binding is highly reproducible in smokers wearing nicotine patches. This suggests that TNP are an acceptable method for controlling cigarette craving during studies that utilize RAC to examine changes in dopamine. © Springer-Verlag 2011.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Karmen K. Yoder; Daniel S. Albrecht; David A. Kareken; Lauren M. Federici; Kevin M. Perry; Elizabeth A. Patton; Qi-Huang Zheng; Bruce H. Mock; Sean O'Connor; Christine M. HerringSynapse. 2011;65(7):553-561.
Jenna M. Sullivan; Shannon L. Risacher; Marc D. Normandin; Karmen K. Yoder; Janice C. Froehlich; Evan D. MorrisSynapse. 2011;65(9):929-937.
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