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Zvjesdana Sever-Chroneos; Cindy J. Bachurski; Cong Yan; Jeffrey A. Whitsett (Profiled Author: Cong Yan)
American Journal of Physiology - Lung Cellular and Molecular Physiology. 1999;277(1 21-1):L79-L88.Abstract
The regulatory role of activator protein-1 (AP-1) family members in mouse surfactant protein (SP) B (mSP-B) promoter function was assessed in the mouse lung epithelial cell line MLE-15. Expression of recombinant Jun B and c-Jun inhibited mSP-B promoter activity by 50-75%. Although c-Fos expression did not alter mSP-B transcription, Jun D enhanced mSP-B promoter activity and reversed inhibition of mSP-B by c-Jun or Jun B. A proximal AP-1 binding site (-18 to -10 bp) was identified that overlaps a thyroid transcription factor- 1 binding site. Mutation of this proximal AP-1 site blocked both Jun B inhibition and Jun D enhancement and partially blocked c-Jun inhibition of promoter activity. Promoter deletion mutants were used to identify additional sequences mediating the inhibitory effects of c-Jun in the distal region from -397 to -253 bp. The AP-1 element in this distal site (-370 to -364 bp) is part of a composite binding site wherein AP-1, cAMP response element binding protein, thyroid transcription factor-1, and nuclear factor I interact. Point mutation of the distal AP-1 binding site partially blocked c-Jun-mediated inhibition of the SP-B promoter. Both stimulatory (Jun D) and inhibitory (c- Jun/Jun B) effects of AP-1 family members on mSP-B promoter activity are mediated by distinct cis-acting elements in the mSP-B 5'-flanking region.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Cong Yan; Jeffrey A. WhitsettJournal of Biological Chemistry. 1997;272(28):17327-17332.
Angela Naltner; Susan Wert; Jeffrey A. Whitsett; Cong YanAmerican Journal of Physiology - Lung Cellular and Molecular Physiology. 2000;279(6 23-6):L1066-L1074.
Angela Naltner; Manely Ghaffari; Jeffrey A. Whitsett; Cong YanJournal of Biological Chemistry. 2000;275(1):56-62.
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