Frangione, Blas

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STRUCTURE OF IMMUNOGLOBULINS AND RELATED PROTEINS

Frangione, Blas

1 September 1978 - 31 March 1999
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
Total Funding: $ 2,819,853

54 Resulting Publications

• 1.

  2004

  Einar M Sigurdsson; Elin Knudsen; Ayodeji Asuni; Cheryl Fitzer-Attas; Daniel Sage; David Quartermain; Fernando Goni; Blas Frangione; Thomas Wisniewski

  An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(28):6277-82.

• 2.

  2003

  Einar M Sigurdsson; David R Brown; Muhammad A Alim; Henrieta Scholtzova; Richard Carp; Harry C Meeker; Frances Prelli; Blas Frangione; Thomas Wisniewski

  Copper chelation delays the onset of prion disease.

  The Journal of biological chemistry 2003;278(47):46199-202.

• 3.

  2003

  Patricia Berasain; Carlos Carmona; Blas Frangione; Juan José Cazzulo; Fernando Goñi

  Specific cleavage sites on human IgG subclasses by cruzipain, the major cysteine proteinase from Trypanosoma cruzi.

  Molecular and biochemical parasitology 2003;130(1):23-9.

• 4.

  2002

  Einar M Sigurdsson; David R Brown; Maki Daniels; Richard J Kascsak; Regina Kascsak; Richard Carp; Harry C Meeker; Blas Frangione; Thomas Wisniewski

  Immunization delays the onset of prion disease in mice.

  The American journal of pathology 2002;161(1):13-7.

• 5.

  2001

  E M Sigurdsson; H Scholtzova; P D Mehta; B Frangione; T Wisniewski

  Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.

  The American journal of pathology 2001;159(2):439-47.

• 6.

  2001

  R Vidal; M Calero; T Révész; G Plant; J Ghiso; B Frangione

  Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family.

  Gene 2001;266(1-2):95-102.

• 7.

  2000

  R Vidal; J Ghiso; B Frangione

  New familial forms of cerebral amyloid and dementia.

  Molecular psychiatry 2000;5(6):575-6.

• 8.

  2000

  R Vidal; M Calero; P Piccardo; M R Farlow; F W Unverzagt; E Méndez; A Jiménez-Huete; R Beavis; G Gallo; E Gomez-Tortosa; et al.

  Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele.

  Acta neuropathologica 2000;100(1):1-12.

• 9.

  2000

  P Berasain; C Carmona; B Frangione; J P Dalton; F Goñi

  Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses: determination of the specific cleavage sites and identification of the immunoglobulin fragments produced.

  Experimental parasitology 2000;94(2):99-110.

• 10.

  2000

  E M Sigurdsson; B Permanne; C Soto; T Wisniewski; B Frangione

  In vivo reversal of amyloid-beta lesions in rat brain.

  Journal of neuropathology and experimental neurology 2000;59(1):11-7.

• 11.

  1999

  R Vidal; F Goñi; F Stevens; P Aucouturier; A Kumar; B Frangione; J Ghiso; G Gallo

  Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition.

  The American journal of pathology 1999;155(6):2009-17.

• 12.

  1999

  P Aucouturier; R J Kascsak; B Frangione; T Wisniewski

  Biochemical and conformational variability of human prion strains in sporadic Creutzfeldt-Jakob disease.

  Neuroscience letters 1999;274(1):33-6.

• 13.

  1999

  E Matsubara; J Ghiso; B Frangione; M Amari; Y Tomidokoro; Y Ikeda; Y Harigaya; K Okamoto; M Shoji

  Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome.

  Annals of neurology 1999;45(4):537-41.

• 14.

  1999

  S Déret; L Denoroy; M Lamarine; R Vidal; B Mougenot; B Frangione; F J Stevens; P M Ronco; P Aucouturier

  Kappa light chain-associated Fanconi's syndrome: molecular analysis of monoclonal immunoglobulin light chains from patients with and without intracellular crystals.

  Protein engineering 1999;12(4):363-9.

• 15.

  1999

  P Aucouturier; B Frangione; T Wisniewski

  Prion diseases and the immune system.

  Annales de médecine interne 1999;150(2):75-8.

• 16.

  1998

  A Jiménez-Huete; P M Lievens; R Vidal; P Piccardo; B Ghetti; F Tagliavini; B Frangione; F Prelli

  Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues.

  The American journal of pathology 1998;153(5):1561-72.

• 17.

  1998

  T Wisniewski; P Aucouturier; C Soto; B Frangione

  The prionoses and other conformational disorders.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1998;5(3):212-24.

• 18.

  1998

  C Soto; E M Sigurdsson; L Morelli; R A Kumar; E M Castaño; B Frangione

  Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

  Nature medicine 1998;4(7):822-6.

• 19.

  1998

  M Pappolla; P Bozner; C Soto; H Shao; N K Robakis; M Zagorski; B Frangione; J Ghiso

  Inhibition of Alzheimer beta-fibrillogenesis by melatonin.

  The Journal of biological chemistry 1998;273(13):7185-8.

• 20.

  1997

  B Kaplan; R Vidal; A Kumar; J Ghiso; B Frangione; G Gallo

  Amino-terminal identity of co-existent amyloid and non-amyloid immunoglobulin kappa light chain deposits. A human disease to study alterations of protein conformation.

  Clinical and experimental immunology 1997;110(3):472-8.

• 21.

  1997

  J Ghiso; M Calero; E Matsubara; S Governale; J Chuba; R Beavis; T Wisniewski; B Frangione

  Alzheimer's soluble amyloid beta is a normal component of human urine.

  FEBS letters 1997;408(1):105-8.

• 22.

  1997

  P Berasaín; F Goñi; S McGonigle; A Dowd; J P Dalton; B Frangione; C Carmona

  Proteinases secreted by Fasciola hepatica degrade extracellular matrix and basement membrane components.

  The Journal of parasitology 1997;83(1):1-5.

• 23.

  1996

  A Rostagno; R Vidal; A Kumar; J Chuba; G Niederman; L Gold; B Frangione; J Ghiso; G Gallo

  Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin-fibronectin complexes.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 1996;28(5):676-84.

• 24.

  1996

  R Vidal; J Ghiso; T Wisniewski; B Frangione

  Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant.

  FEBS letters 1996;393(1):19-23.

• 25.

  1996

  F Perini; R Vidal; B Ghetti; F Tagliavini; B Frangione; F Prelli

  PrP27-30 is a normal soluble prion protein fragment released by human platelets.

  Biochemical and biophysical research communications 1996;223(3):572-7.

• 26.

  1996

  F Perini; B Frangione; F Prelli

  Prion protein released by platelets.

  Lancet 1996;347(9015):1635-6.

• 27.

  1996

  E Matsubara; C Soto; S Governale; B Frangione; J Ghiso

  Apolipoprotein J and Alzheimer's amyloid beta solubility.

  The Biochemical journal 1996;316 ( Pt 2)():671-9.

• 28.

  1996

  G Gallo; F Goñi; F Boctor; R Vidal; A Kumar; F J Stevens; B Frangione; J Ghiso

  Light chain cardiomyopathy. Structural analysis of the light chain tissue deposits.

  The American journal of pathology 1996;148(5):1397-406.

• 29.

  1995

  E M Castaño; F Prelli; M Pras; B Frangione

  Apolipoprotein E carboxyl-terminal fragments are complexed to amyloids A and L. Implications for amyloidogenesis and Alzheimer's disease.

  The Journal of biological chemistry 1995;270(29):17610-5.

• 30.

  1994

  G Gallo; T Wisniewski; N H Choi-Miura; J Ghiso; B Frangione

  Potential role of apolipoprotein-E in fibrillogenesis.

  The American journal of pathology 1994;145(3):526-30.

• 31.

  1994

  T Wisniewski; J Ghiso; B Frangione

  Alzheimer's disease and soluble A beta.

  Neurobiology of aging 1994;15(2):143-52.

• 32.

  1993

  T Wisniewski; E Castano; J Ghiso; B Frangione

  Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro.

  Annals of neurology 1993;34(4):631-3.

• 33.

  1993

  T Wisniewski; A Golabek; E Matsubara; J Ghiso; B Frangione

  Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid.

  Biochemical and biophysical research communications 1993;192(2):359-65.

• 34.

  1992

  M Shoji; T E Golde; J Ghiso; T T Cheung; S Estus; L M Shaffer; X D Cai; D M McKay; R Tintner; B Frangione

  Production of the Alzheimer amyloid beta protein by normal proteolytic processing.

  Science (New York, N.Y.) 1992;258(5079):126-9.

• 35.

  1992

  R G Vidal; J Ghiso; G Gallo; M Cohen; P L Gambetti; B Frangione

  Amyloidoma of the CNS. II. Immunohistochemical and biochemical study.

  Neurology 1992;42(10):2024-8.

• 36.

  1992

  H Heyermann; J E Butler; B Frangione

  The heterogeneity of bovine IgG2--V. Differences in the primary structure of bovine IgG2 allotypes.

  Molecular immunology 1992;29(9):1147-52.

• 37.

  1992

  H Ayadi; E Mihaesco; N Congy; J P Roy; M C Gendron; J Laperriere; F Prelli; B Frangione; J C Brouet

  H chain V region sequences of three human monoclonal IgM with anti-myelin-associated glycoprotein activity.

  Journal of immunology (Baltimore, Md. : 1950) 1992;148(9):2812-6.

• 38.

  1992

  T Wisniewski; B Frangione

  Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid.

  Neuroscience letters 1992;135(2):235-8.

• 39.

  1992

  M Haltia; E Levy; J Meretoja; I Fernandez-Madrid; O Koivunen; B Frangione

  Gelsolin gene mutation--at codon 187--in familial amyloidosis, Finnish: DNA-diagnostic assay.

  American journal of medical genetics 1992;42(3):357-9.

• 40.

  1992

  F Prelli; B Frangione

  Franklin's disease: Ig gamma 2 H chain mutant BUR.

  Journal of immunology (Baltimore, Md. : 1950) 1992;148(3):949-52.

• 41.

  1991

  P D Gorevic; P C Munoz; G Gorgone; J J Purcell; M Rodrigues; J Ghiso; E Levy; M Haltia; B Frangione

  Amyloidosis due to a mutation of the gelsolin gene in an American family with lattice corneal dystrophy type II.

  The New England journal of medicine 1991;325(25):1780-5.

• 42.

  1991

  A P Kuruvilla; G M Hochwald; J Ghiso; E M Castaño; M Pizzolato; B Frangione

  Isolation and amino terminal sequence of beta-trace, a novel protein from human cerebrospinal fluid.

  Brain research 1991;565(2):337-40.

• 43.

  1991

  E M Castaño; T Wisniewski; B Frangione

  Inherited amyloids of the nervous system.

  Current opinion in neurobiology 1991;1(3):448-54.

• 44.

  1991

  M Haltia; J Ghiso; T Wisniewski; S Kiuru; D Miller; B Frangione

  Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies.

  Neurobiology of aging 1991;12(4):313-6.

• 45.

  1991

  E M Castaño; B Frangione

  Alzheimer's disease from the perspective of the systemic and localized forms of amyloidosis.

  Brain pathology (Zurich, Switzerland) 1991;1(4):263-71.

• 46.

  1991

  T Wisniewski; M Haltia; J Ghiso; B Frangione

  Lewy bodies are immunoreactive with antibodies raised to gelsolin related amyloid-Finnish type.

  The American journal of pathology 1991;138(5):1077-83.

• 47.

  1991

  F Tagliavini; F Prelli; J Ghiso; O Bugiani; D Serban; S B Prusiner; M R Farlow; B Ghetti; B Frangione

  Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.

  The EMBO journal 1991;10(3):513-9.

• 48.

  1991

  J Leoni; J Ghiso; F Goñi; B Frangione

  The primary structure of the Fab fragment of protein KAU, a monoclonal immunoglobulin M cold agglutinin.

  The Journal of biological chemistry 1991;266(5):2836-42.

• 49.

  1990

  J E Gardella; J Ghiso; G A Gorgone; D Marratta; A P Kaplan; B Frangione; P D Gorevic

  Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA.

  Biochemical and biophysical research communications 1990;173(3):1292-8.

• 50.

  1990

  J Ghiso; M Haltia; F Prelli; J Novello; B Frangione

  Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type.

  The Biochemical journal 1990;272(3):827-30.

• 51.

  1990

  E Levy; M Haltia; I Fernandez-Madrid; O Koivunen; J Ghiso; F Prelli; B Frangione

  Mutation in gelsolin gene in Finnish hereditary amyloidosis.

  The Journal of experimental medicine 1990;172(6):1865-7.

• 52.

  1990

  J L Barnes; F Goñi; H Heyermann; B Frangione; V Agnello

  Human rheumatoid factor cross-idiotypes. III. Bla monoclonal rheumatoid factor, prototype of the BLA cross-idiotype group, has distinct kappa chains related to the V kappa III subgroup and VH4 heavy chains.

  Arthritis and rheumatism 1990;33(11):1710-5.

• 53.

  1989

  E Mihaesco; H Ayadi; N Congy; M C Gendron; J P Roy; H Heyermann; B Frangione; J C Brouet

  Multiple mutations in the variable region of the kappa light chains of three monoclonal human IgM with anti-myelin-associated glycoprotein activity.

  The Journal of biological chemistry 1989;264(36):21481-5.

• 54.

  1989

  F R Goñi; P P Chen; D McGinnis; M L Arjonilla; J Fernandez; D Carson; A Solomon; E Mendez; B Frangione

  Structural and idiotypic characterization of the L chains of human IgM autoantibodies with different specificities.

  Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3158-63.

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