AMYLOIDOSIS AND ALZHEIMERS DISEASE

Grant Detail

The grant detail shows the name of the PI, active dates of the project, the funding institute and the abstract of the grant. This abstract is what is used to create the fingerprint of the grant. If any publications referencing this grant are found in the data, they will be listed here as well.

Frangione, Blas

1 July 1985 - 30 June 1997
NATIONAL INSTITUTE ON AGING
Total Funding: $ 3,049,140

FY 1995

5R01AG005891-11

$ 360,690

FY 1994

5R01AG005891-10

$ 349,835

FY 1993

5R01AG005891-09

$ 315,787

FY 1992

5R01AG005891-08

$ 317,837

FY 1991

2R01AG005891-07

$ 300,442

FY 1990

5R01AG005891-06

$ 211,482

FY 1989

5R01AG005891-05

$ 199,388

FY 1988

2R01AG005891-04

$ 195,300

FY 1987

5R01AG005891-03

$ 262,961

FY 1986

5R01AG005891-02

$ 268,519

FY 1985

1R01AG005891-01

$ 266,899

$ 3,049,140

141 Resulting Publications

1.
2010

Yasushi Tomidokoro; Agueda Rostagno; Thomas A Neubert; Yun Lu; G William Rebeck; Blas Frangione; Steven M Greenberg; Jorge Ghiso

Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits.
The American journal of pathology 2010;176(4):1841-54.
2.
2009

Stéphanie G Trouche; Ayodeji Asuni; Sylvie Rouland; Thomas Wisniewski; Blas Frangione; Jean-Michel Verdier; Einar M Sigurdsson; Nadine Mestre-Francés

Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives.
Vaccine 2009;27(7):957-64.
3.
2009

Allal Boutajangout; Fernando Goni; Elin Knudsen; Fernanda Schreiber; Ayodeji Asuni; David Quartermain; Blas Frangione; Alejandro Chabalgoity; Thomas Wisniewski; Einar M Sigurdsson

Diminished amyloid-beta burden in Tg2576 mice following a prophylactic oral immunization with a salmonella-based amyloid-beta derivative vaccine.
Journal of Alzheimer's disease : JAD 2009;18(4):961-72.
4.
2008

T Lashley; T Revesz; G Plant; R Bandopadhyay; A J Lees; B Frangione; N W Wood; R de Silva; J Ghiso; A Rostagno; et al.

Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease.
Neuropathology and applied neurobiology 2008;34(5):492-505.
5.
2007

Agueda Rostagno; Tammaryn Lashley; Douglas Ng; Jordana Meyerson; Hans Braendgaard; Gordon Plant; Marie Bojsen-Møller; Janice Holton; Blas Frangione; Tamas Revesz; et al.

Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease.
Journal of the neurological sciences 2007;257(1-2):88-96.
6.
2006

Ayodeji A Asuni; Allal Boutajangout; Henrieta Scholtzova; Elin Knudsen; Yong Sheng Li; David Quartermain; Blas Frangione; Thomas Wisniewski; Einar M Sigurdsson

Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages.
The European journal of neuroscience 2006;24(9):2530-42.
7.
2006

T Lashley; J L Holton; M M Verbeek; A Rostagno; M Bojsen-Møller; G David; J van Horssen; H Braendgaard; G Plant; B Frangione; et al.

Molecular chaperons, amyloid and preamyloid lesions in the BRI2 gene-related dementias: a morphological study.
Neuropathology and applied neurobiology 2006;32(5):492-504.
8.
2006

María C Leal; Verónica B Dorfman; Agata Fernández Gamba; Blas Frangione; Thomas Wisniewski; Eduardo M Castaño; Einar M Sigurdsson; Laura Morelli

Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology.
Journal of neuropathology and experimental neurology 2006;65(10):976-87.
9.
2006

J Ghiso; A Rostagno; Y Tomidokoro; T Lashley; M Bojsen-Møller; H Braendgaard; G Plant; J Holton; R Lal; T Revesz; et al.

Genetic alterations of the BRI2 gene: familial British and Danish dementias.
Brain pathology (Zurich, Switzerland) 2006;16(1):71-9.
10.
2006

Efrat Levy; Frances Prelli; Blas Frangione

Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):329-39.
11.
2005

Yasushi Tomidokoro; Tammaryn Lashley; Agueda Rostagno; Thomas A Neubert; Marie Bojsen-Møller; Hans Braendgaard; Gordon Plant; Janice Holton; Blas Frangione; Tamas Révész; et al.

Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques.
The Journal of biological chemistry 2005;280(44):36883-94.
12.
2005

Angeliki Fotinopoulou; Maria Tsachaki; Maria Vlavaki; Alexandros Poulopoulos; Agueda Rostagno; Blas Frangione; Jorge Ghiso; Spiros Efthimiopoulos

BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
The Journal of biological chemistry 2005;280(35):30768-72.
13.
2005

Shuji Matsuda; Luca Giliberto; Yukiko Matsuda; Peter Davies; Eileen McGowan; Fiona Pickford; Jorge Ghiso; Blas Frangione; Luciano D'Adamio

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.
The Journal of biological chemistry 2005;280(32):28912-6.
14.
2005

A Rostagno; Y Tomidokoro; T Lashley; D Ng; G Plant; J Holton; B Frangione; T Revesz; J Ghiso

Chromosome 13 dementias.
Cellular and molecular life sciences : CMLS 2005;62(16):1814-25.
15.
2005

Arjan Quist; Ivo Doudevski; Hai Lin; Rushana Azimova; Douglas Ng; Blas Frangione; Bruce Kagan; Jorge Ghiso; Ratnesh Lal

Amyloid ion channels: a common structural link for protein-misfolding disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10427-32.
16.
2005

Laura Morelli; Ramiro E Llovera; Leonardo G Alonso; Blas Frangione; Gonzalo de Prat-Gay; Jorge Ghiso; Eduardo M Castaño

Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia.
Biochemical and biophysical research communications 2005;332(3):808-16.
17.
2005

Miguel Calero; Agueda Rostagno; Blas Frangione; Jorge Ghiso

Clusterin and Alzheimer's disease.
Sub-cellular biochemistry 2005;38():273-98.
18.
2005

Thomas Wisniewski; Blas Frangione

Immunological and anti-chaperone therapeutic approaches for Alzheimer disease.
Brain pathology (Zurich, Switzerland) 2005;15(1):72-7.
19.
2004

Laura Morelli; Ramiro E Llovera; Irina Mathov; Lih-Fen Lue; Blas Frangione; Jorge Ghiso; Eduardo M Castaño

Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.
The Journal of biological chemistry 2004;279(53):56004-13.
20.
2004

Jorge Ghiso; Marcos Shayo; Miguel Calero; Douglas Ng; Yasushi Tomidokoro; Samuel Gandy; Agueda Rostagno; Blas Frangione

Systemic catabolism of Alzheimer's Abeta40 and Abeta42.
The Journal of biological chemistry 2004;279(44):45897-908.
21.
2004

Etsuro Matsubara; Yoshiki Sekijima; Takahiko Tokuda; Katsuya Urakami; Masakuni Amari; Masami Shizuka-Ikeda; Yasushi Tomidokoro; Masaki Ikeda; Takeshi Kawarabayashi; Yasuo Harigaya; et al.

Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins.
Neurobiology of aging 2004;25(7):833-41.
22.
2004

Einar M Sigurdsson; Elin Knudsen; Ayodeji Asuni; Cheryl Fitzer-Attas; Daniel Sage; David Quartermain; Fernando Goni; Blas Frangione; Thomas Wisniewski

An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(28):6277-82.
23.
2003

Tamas Revesz; Jorge Ghiso; Tammaryn Lashley; Gordon Plant; Agueda Rostagno; Blas Frangione; Janice L Holton

Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view.
Journal of neuropathology and experimental neurology 2003;62(9):885-98.
24.
2002

Jorge Ghiso; Blas Frangione

Amyloidosis and Alzheimer's disease.
Advanced drug delivery reviews 2002;54(12):1539-51.
25.
2002

Einar M Sigurdsson; Thomas Wisniewski; Blas Frangione

A safer vaccine for Alzheimer's disease?
Neurobiology of aging 2002;23(6):1001-8.
26.
2002

Einar M Sigurdsson; David R Brown; Maki Daniels; Richard J Kascsak; Regina Kascsak; Richard Carp; Harry C Meeker; Blas Frangione; Thomas Wisniewski

Immunization delays the onset of prion disease in mice.
The American journal of pathology 2002;161(1):13-7.
27.
2002

Tamas Revesz; Janice L Holton; Tammaryn Lashley; Gordon Plant; Agueda Rostagno; Jorge Ghiso; Blas Frangione

Sporadic and familial cerebral amyloid angiopathies.
Brain pathology (Zurich, Switzerland) 2002;12(3):343-57.
28.
2002

Jasmina B Mackic; James Bading; Jorge Ghiso; Larry Walker; Thomas Wisniewski; Blas Frangione; Berislav V Zlokovic

Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.
Vascular pharmacology 2002;38(6):303-13.
29.
2002

O R Monro; J B Mackic; S Yamada; M B Segal; J Ghiso; C Maurer; M Calero; B Frangione; B V Zlokovic

Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood.
Neurobiology of aging 2002;23(3):405-12.
30.
2002

Janice L Holton; Tammaryn Lashley; Jorge Ghiso; Hans Braendgaard; Ruben Vidal; Christopher J Guerin; Graham Gibb; Diane P Hanger; Agueda Rostagno; Brian H Anderton; et al.

Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.
Journal of neuropathology and experimental neurology 2002;61(3):254-67.
31.
2001

B Poeggeler; L Miravalle; M G Zagorski; T Wisniewski; Y J Chyan; Y Zhang; H Shao; T Bryant-Thomas; R Vidal; B Frangione; et al.

Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide.
Biochemistry 2001;40(49):14995-5001.
32.
2001

J Ghiso; T Révész; J Holton; A Rostagno; T Lashley; H Houlden; G Gibb; B Anderton; T Bek; M Bojsen-Møller; et al.

Chromosome 13 dementia syndromes as models of neurodegeneration.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8(4):277-84.
33.
2001

J A Ghiso; J Holton; L Miravalle; M Calero; T Lashley; R Vidal; H Houlden; N Wood; T A Neubert; A Rostagno; et al.

Systemic amyloid deposits in familial British dementia.
The Journal of biological chemistry 2001;276(47):43909-14.
34.
2001

E M Sigurdsson; H Scholtzova; P D Mehta; B Frangione; T Wisniewski

Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.
The American journal of pathology 2001;159(2):439-47.
35.
2001

B Frangione; T Révész; R Vidal; J Holton; T Lashley; H Houlden; N Wood; A Rostagno; G Plant; J Ghiso

Familial cerebral amyloid angiopathy related to stroke and dementia.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8 Suppl 1():36-42.
36.
2001

M Calero; M Pawlik; C Soto; E M Castaño; E M Sigurdsson; A Kumar; G Gallo; B Frangione; E Levy

Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type.
Journal of neurochemistry 2001;77(2):628-37.
37.
2001

R Vidal; M Calero; T Révész; G Plant; J Ghiso; B Frangione

Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family.
Gene 2001;266(1-2):95-102.
38.
2001

J L Holton; J Ghiso; T Lashley; A Rostagno; C J Guerin; G Gibb; H Houlden; H Ayling; L Martinian; B H Anderton; et al.

Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia.
The American journal of pathology 2001;158(2):515-26.
39.
2000

M Shibata; S Yamada; S R Kumar; M Calero; J Bading; B Frangione; D M Holtzman; C A Miller; D K Strickland; J Ghiso; et al.

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
The Journal of clinical investigation 2000;106(12):1489-99.
40.
2000

R Vidal; J Ghiso; B Frangione

New familial forms of cerebral amyloid and dementia.
Molecular psychiatry 2000;5(6):575-6.
41.
2000

L Miravalle; T Tokuda; R Chiarle; G Giaccone; O Bugiani; F Tagliavini; B Frangione; J Ghiso

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.
The Journal of biological chemistry 2000;275(35):27110-6.
42.
2000

M Calero; A Rostagno; E Matsubara; B Zlokovic; B Frangione; J Ghiso

Apolipoprotein J (clusterin) and Alzheimer's disease.
Microscopy research and technique 2000;50(4):305-15.
43.
2000

T Tokuda; M Calero; E Matsubara; R Vidal; A Kumar; B Permanne; B Zlokovic; J D Smith; M J Ladu; A Rostagno; et al.

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.
The Biochemical journal 2000;348 Pt 2():359-65.
44.
2000

S Mead; M James-Galton; T Revesz; R B Doshi; G Harwood; E L Pan; J Ghiso; B Frangione; G Plant

Familial British dementia with amyloid angiopathy: early clinical, neuropsychological and imaging findings.
Brain : a journal of neurology 2000;123 ( Pt 5)():975-91.
45.
2000

R Vidal; T Revesz; A Rostagno; E Kim; J L Holton; T Bek; M Bojsen-Møller; H Braendgaard; G Plant; J Ghiso; et al.

A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4920-5.
46.
2000

E M Sigurdsson; B Permanne; C Soto; T Wisniewski; B Frangione

In vivo reversal of amyloid-beta lesions in rat brain.
Journal of neuropathology and experimental neurology 2000;59(1):11-7.
47.
2000

B Frangione; R Vidal; A Rostagno; J Ghiso

Familial cerebral amyloid angiopathies and dementia.
Alzheimer disease and associated disorders 2000;14 Suppl 1():S25-30.
48.
1999

M Calero; T Tokuda; A Rostagno; A Kumar; B Zlokovic; B Frangione; J Ghiso

Functional and structural properties of lipid-associated apolipoprotein J (clusterin).
The Biochemical journal 1999;344 Pt 2():375-83.
49.
1999

A Rostagno; R Vidal; B Kaplan; J Chuba; A Kumar; J I Elliott; B Frangione; G Gallo; J Ghiso

pH-dependent fibrillogenesis of a VkappaIII Bence Jones protein.
British journal of haematology 1999;107(4):835-43.
50.
1999

Y J Chyan; B Poeggeler; R A Omar; D G Chain; B Frangione; J Ghiso; M A Pappolla

Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid.
The Journal of biological chemistry 1999;274(31):21937-42.
51.
1999

J F Poduslo; G L Curran; A Kumar; B Frangione; C Soto

Beta-sheet breaker peptide inhibitor of Alzheimer's amyloidogenesis with increased blood-brain barrier permeability and resistance to proteolytic degradation in plasma.
Journal of neurobiology 1999;39(3):371-82.
52.
1999

E Matsubara; J Ghiso; B Frangione; M Amari; Y Tomidokoro; Y Ikeda; Y Harigaya; K Okamoto; M Shoji

Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome.
Annals of neurology 1999;45(4):537-41.
53.
1998

F Crawford; C Soto; Z Suo; C Fang; T Parker; A Sawar; B Frangione; M Mullan

Alzheimer's beta-amyloid vasoactivity: identification of a novel beta-amyloid conformational intermediate.
FEBS letters 1998;436(3):445-8.
54.
1998

J B Mackic; M Stins; J G McComb; M Calero; J Ghiso; K S Kim; S D Yan; D Stern; A M Schmidt; B Frangione; et al.

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.
The Journal of clinical investigation 1998;102(4):734-43.
55.
1998

C Soto; E M Sigurdsson; L Morelli; R A Kumar; E M Castaño; B Frangione

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.
Nature medicine 1998;4(7):822-6.
56.
1998

M Pappolla; P Bozner; C Soto; H Shao; N K Robakis; M Zagorski; B Frangione; J Ghiso

Inhibition of Alzheimer beta-fibrillogenesis by melatonin.
The Journal of biological chemistry 1998;273(13):7185-8.
57.
1998

T Wisniewski; W K Dowjat; J D Buxbaum; O Khorkova; S Efthimiopoulos; J Kulczycki; W Lojkowska; J Wegiel; H M Wisniewski; B Frangione

A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years.
Neuroreport 1998;9(2):217-21.
58.
1998

J B Mackic; M H Weiss; W Miao; E Kirkman; J Ghiso; M Calero; J Bading; B Frangione; B V Zlokovic

Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy.
Journal of neurochemistry 1998;70(1):210-5.
59.
1997

B Permanne; C Perez; C Soto; B Frangione; T Wisniewski

Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants.
Biochemical and biophysical research communications 1997;240(3):715-20.
60.
1997

T Wisniewski; W K Dowjat; B Permanne; J Palha; A Kumar; G Gallo; B Frangione

Presenilin-1 is associated with Alzheimer's disease amyloid.
The American journal of pathology 1997;151(2):601-10.
61.
1997

J Ghiso; M Calero; E Matsubara; S Governale; J Chuba; R Beavis; T Wisniewski; B Frangione

Alzheimer's soluble amyloid beta is a normal component of human urine.
FEBS letters 1997;408(1):105-8.
62.
1996

M Lalowski; A Golabek; C A Lemere; D J Selkoe; H M Wisniewski; R C Beavis; B Frangione; T Wisniewski

The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid.
The Journal of biological chemistry 1996;271(52):33623-31.
63.
1996

E M Castaño; F Prelli; C Soto; R Beavis; E Matsubara; M Shoji; B Frangione

The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease.
The Journal of biological chemistry 1996;271(50):32185-91.
64.
1996

C Soto; M S Kindy; M Baumann; B Frangione

Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation.
Biochemical and biophysical research communications 1996;226(3):672-80.
65.
1996

R Vidal; J Ghiso; T Wisniewski; B Frangione

Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant.
FEBS letters 1996;393(1):19-23.
66.
1996

J F Ghersi-Egea; P D Gorevic; J Ghiso; B Frangione; C S Patlak; J D Fenstermacher

Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries.
Journal of neurochemistry 1996;67(2):880-3.
67.
1996

F Perini; R Vidal; B Ghetti; F Tagliavini; B Frangione; F Prelli

PrP27-30 is a normal soluble prion protein fragment released by human platelets.
Biochemical and biophysical research communications 1996;223(3):572-7.
68.
1996

F Perini; B Frangione; F Prelli

Prion protein released by platelets.
Lancet 1996;347(9015):1635-6.
69.
1996

E Matsubara; C Soto; S Governale; B Frangione; J Ghiso

Apolipoprotein J and Alzheimer's amyloid beta solubility.
The Biochemical journal 1996;316 ( Pt 2)():671-9.
70.
1996

R Vidal; F Garzuly; H Budka; M Lalowski; R P Linke; F Brittig; B Frangione; T Wisniewski

Meningocerebrovascular amyloidosis associated with a novel transthyretin mis-sense mutation at codon 18 (TTRD 18G)
The American journal of pathology 1996;148(2):361-6.
71.
1996

T Wisniewski; M Lalowski; M Baumann; H Rauvala; E Raulo; R Nolo; B Frangione

HB-GAM is a cytokine present in Alzheimer's and Down's syndrome lesions.
Neuroreport 1996;7(2):667-71.
72.
1996

L Morelli; L Wei; A Amorim; J McDermid; C R Abee; B Frangione; L C Walker; E Levy

Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype.
FEBS letters 1996;379(2):132-4.
73.
1996

T Wisniewski; M Lalowski; M Bobik; M Russell; J Strosznajder; B Frangione

Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs.
The Biochemical journal 1996;313 ( Pt 2)():575-80.
74.
1996

T Wisniewski; B Frangione

Molecular biology of brain aging and neurodegenerative disorders.
Acta neurobiologiae experimentalis 1996;56(1):267-79.
75.
1995

C Soto; E M Castaño; R A Kumar; R C Beavis; B Frangione

Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure.
Neuroscience letters 1995;200(2):105-8.
76.
1995

E M Castaño; B Frangione

Non-Alzheimer's disease amyloidoses of the nervous system.
Current opinion in neurology 1995;8(4):279-85.
77.
1995

T Wisniewski; A A Golabek; E Kida; K E Wisniewski; B Frangione

Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis.
The American journal of pathology 1995;147(2):238-44.
78.
1995

E M Castaño; F Prelli; M Pras; B Frangione

Apolipoprotein E carboxyl-terminal fragments are complexed to amyloids A and L. Implications for amyloidogenesis and Alzheimer's disease.
The Journal of biological chemistry 1995;270(29):17610-5.
79.
1995

T Wisniewski; M Lalowski; A Golabek; T Vogel; B Frangione

Is Alzheimer's disease an apolipoprotein E amyloidosis?
Lancet 1995;345(8955):956-8.
80.
1995

M A Smith; S L Siedlak; P L Richey; P Mulvihill; J Ghiso; B Frangione; F Tagliavini; G Giaccone; O Bugiani; D Praprotnik

Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease.
Nature medicine 1995;1(4):365-9.
81.
1995

E Matsubara; B Frangione; J Ghiso

Characterization of apolipoprotein J-Alzheimer's A beta interaction.
The Journal of biological chemistry 1995;270(13):7563-7.
82.
1995

E M Castano; F Prelli; T Wisniewski; A Golabek; R A Kumar; C Soto; B Frangione

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.
The Biochemical journal 1995;306 ( Pt 2)():599-604.
83.
1995

C Soto; B Frangione

Two conformational states of amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease.
Neuroscience letters 1995;186(2-3):115-8.
84.
1995

C Soto; E M Castaño; B Frangione; N C Inestrosa

The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation.
The Journal of biological chemistry 1995;270(7):3063-7.
85.
1995

C A Mangone; E M Castaño; E Levy; G Abiusi; T Wisniewski; M R Marques; E Faccio; P B Gorelick; B Frangione; R E Sica

Early onset Alzheimer's disease in a South American pedigree from Argentina.
Acta neurologica Scandinavica 1995;91(1):6-13.
86.
1994

A Koudinov; E Matsubara; B Frangione; J Ghiso

The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma.
Biochemical and biophysical research communications 1994;205(2):1164-71.
87.
1994

S Gandy; G Caporaso; J Buxbaum; B Frangione; P Greengard

APP processing, A beta-amyloidogenesis, and the pathogenesis of Alzheimer's disease.
Neurobiology of aging 1994;15(2):253-6.
88.
1993

J E Gardella; G A Gorgone; L Candela; J Ghiso; E M Castaño; B Frangione; P D Gorevic

High-level expression and in vitro mutagenesis of a fibrillogenic 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein.
The Biochemical journal 1993;294 ( Pt 3)():667-74.
89.
1993

J Ghiso; E Matsubara; A Koudinov; N H Choi-Miura; M Tomita; T Wisniewski; B Frangione

The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.
The Biochemical journal 1993;293 ( Pt 1)():27-30.
90.
1993

F Tagliavini; G Giaccone; O Bugiani; B Frangione

Ubiquitinated neurites are associated with preamyloid and cerebral amyloid beta deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type.
Acta neuropathologica 1993;85(3):267-71.
91.
1992

J Ghiso; A Rostagno; J E Gardella; L Liem; P D Gorevic; B Frangione

A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion.
The Biochemical journal 1992;288 ( Pt 3)():1053-9.
92.
1992

M Shoji; T E Golde; J Ghiso; T T Cheung; S Estus; L M Shaffer; X D Cai; D M McKay; R Tintner; B Frangione

Production of the Alzheimer amyloid beta protein by normal proteolytic processing.
Science (New York, N.Y.) 1992;258(5079):126-9.
93.
1992

J E Gardella; G A Gorgone; P C Munoz; J Ghiso; B Frangione; P D Gorevic

Beta protein precursor expression in human platelets and a megakaryocyte cell line. Possible implications for the origin of cerebral amyloidosis in Alzheimer's disease.
Laboratory investigation; a journal of technical methods and pathology 1992;67(3):303-13.
94.
1992

J E Gardella; G A Gorgone; P Newman; B Frangione; P D Gorevic

Characterization of Alzheimer amyloid precursor protein transcripts in platelets and megakarocytes.
Neuroscience letters 1992;138(2):229-32.
95.
1992

J Ghiso; T Wisniewski; R Vidal; A Rostagno; B Frangione

Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease.
The Biochemical journal 1992;282 ( Pt 2)():517-22.
96.
1992

M Haltia; E Levy; J Meretoja; I Fernandez-Madrid; O Koivunen; B Frangione

Gelsolin gene mutation--at codon 187--in familial amyloidosis, Finnish: DNA-diagnostic assay.
American journal of medical genetics 1992;42(3):357-9.
97.
1992

F Tagliavini; G Giaccone; L Verga; B Frangione; O Bugiani

Down syndrome as a key to the time sequence of brain changes in Alzheimer disease.
Progress in clinical and biological research 1992;379():143-58.
98.
1991

I Fernandez-Madrid; E Levy; K Marder; B Frangione

Codon 618 variant of Alzheimer amyloid gene associated with inherited cerebral hemorrhage.
Annals of neurology 1991;30(5):730-3.
99.
1991

E M Castaño; T Wisniewski; B Frangione

Inherited amyloids of the nervous system.
Current opinion in neurobiology 1991;1(3):448-54.
100.
1991

T Wisniewski; J Ghiso; B Frangione

Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Biochemical and biophysical research communications 1991;179(3):1247-54.
101.
1991

K H el Hachimi; L Verga; G Giaccone; F Tagliavini; B Frangione; O Bugiani; J F Foncin

Relationship between non-fibrillary amyloid precursors and cell processes in the cortical neuropil of Alzheimer patients.
Neuroscience letters 1991;129(1):119-22.
102.
1991

F Tagliavini; G Giaccone; L Verga; J Ghiso; B Frangione; O Bugiani

Alzheimer patients: preamyloid deposits are immunoreactive with antibodies to extracellular domains of the amyloid precursor protein.
Neuroscience letters 1991;128(1):117-20.
103.
1991

M Haltia; J Ghiso; T Wisniewski; S Kiuru; D Miller; B Frangione

Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies.
Neurobiology of aging 1991;12(4):313-6.
104.
1991

E M Castaño; B Frangione

Alzheimer's disease from the perspective of the systemic and localized forms of amyloidosis.
Brain pathology (Zurich, Switzerland) 1991;1(4):263-71.
105.
1991

T Wisniewski; M Haltia; J Ghiso; B Frangione

Lewy bodies are immunoreactive with antibodies raised to gelsolin related amyloid-Finnish type.
The American journal of pathology 1991;138(5):1077-83.
106.
1991

F Tagliavini; F Prelli; J Ghiso; O Bugiani; D Serban; S B Prusiner; M R Farlow; B Ghetti; B Frangione

Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.
The EMBO journal 1991;10(3):513-9.
107.
1990

J Ghiso; M Haltia; F Prelli; J Novello; B Frangione

Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type.
The Biochemical journal 1990;272(3):827-30.
108.
1990

E Levy; M Haltia; I Fernandez-Madrid; O Koivunen; J Ghiso; F Prelli; B Frangione

Mutation in gelsolin gene in Finnish hereditary amyloidosis.
The Journal of experimental medicine 1990;172(6):1865-7.
109.
1990

O Bugiani; G Giaccone; L Verga; B Pollo; B Ghetti; B Frangione; F Tagliavini

Alzheimer patients and Down patients: abnormal presynaptic terminals are related to cerebral preamyloid deposits.
Neuroscience letters 1990;119(1):56-9.
110.
1990

G Giaccone; F Tagliavini; L Verga; B Frangione; M R Farlow; O Bugiani; B Ghetti

Neurofibrillary tangles of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease share antigenic determinants with those of Alzheimer disease.
Brain research 1990;530(2):325-9.
111.
1990

W F Timmers; F Tagliavini; J Haan; B Frangione

Parenchymal preamyloid and amyloid deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis--Dutch type.
Neuroscience letters 1990;118(2):223-6.
112.
1990

F Prelli; E Levy; S G van Duinen; G T Bots; W Luyendijk; B Frangione

Expression of a normal and variant Alzheimer's beta-protein gene in amyloid of hereditary cerebral hemorrhage, Dutch type: DNA and protein diagnostic assays.
Biochemical and biophysical research communications 1990;170(1):301-7.
113.
1990

G Giaccone; L Verga; M Finazzi; B Pollo; F Tagliavini; B Frangione; O Bugiani

Cerebral preamyloid deposits and congophilic angiopathy in aged dogs.
Neuroscience letters 1990;114(2):178-83.
114.
1990

E Levy; M D Carman; I J Fernandez-Madrid; M D Power; I Lieberburg; S G van Duinen; G T Bots; W Luyendijk; B Frangione

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.
Science (New York, N.Y.) 1990;248(4959):1124-6.
115.
1990

F Tagliavini; J Ghiso; W F Timmers; G Giaccone; O Bugiani; B Frangione

Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls.
Laboratory investigation; a journal of technical methods and pathology 1990;62(6):761-7.
116.
1990

M Haltia; J Ghiso; F Prelli; G Gallo; S Kiuru; H Somer; J Palo; B Frangione

Amyloid in familial amyloidosis, Finnish type, is antigenically and structurally related to gelsolin.
The American journal of pathology 1990;136(6):1223-8.
117.
1990

M Haltia; F Prelli; J Ghiso; S Kiuru; H Somer; J Palo; B Frangione

Amyloid protein in familial amyloidosis (Finnish type) is homologous to gelsolin, an actin-binding protein.
Biochemical and biophysical research communications 1990;167(3):927-32.
118.
1990

M M Picken; M Larrondo-Lillo; F Coria; G R Gallo; M L Shelanski; B Frangione

Distribution of the protease inhibitor alpha 1-antichymotrypsin in cerebral and systemic amyloid.
Journal of neuropathology and experimental neurology 1990;49(1):41-8.
119.
1989

L Verga; B Frangione; F Tagliavini; G Giaccone; A Migheli; O Bugiani

Alzheimer patients and Down patients: cerebral preamyloid deposits differ ultrastructurally and histochemically from the amyloid of senile plaques.
Neuroscience letters 1989;105(3):294-9.
120.
1989

O Bugiani; G Giaccone; B Frangione; B Ghetti; F Tagliavini

Alzheimer patients: preamyloid deposits are more widely distributed than senile plaques throughout the central nervous system.
Neuroscience letters 1989;103(3):263-8.
121.
1989

J Ghiso; F Tagliavini; W F Timmers; B Frangione

Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization.
Biochemical and biophysical research communications 1989;163(1):430-7.
122.
1989

E Levy; C Lopez-Otin; J Ghiso; D Geltner; B Frangione

Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases.
The Journal of experimental medicine 1989;169(5):1771-8.
123.
1989

P D Gorevic; F C Prelli; J Wright; M Pras; B Frangione

Systemic senile amyloidosis. Identification of a new prealbumin (transthyretin) variant in cardiac tissue: immunologic and biochemical similarity to one form of familial amyloidotic polyneuropathy.
The Journal of clinical investigation 1989;83(3):836-43.
124.
1989

G Giaccone; F Tagliavini; G Linoli; C Bouras; L Frigerio; B Frangione; O Bugiani

Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques.
Neuroscience letters 1989;97(1-2):232-8.
125.
1989

F Tagliavini; G Giaccone; G Linoli; B Frangione; O Bugiani

Cerebral extracellular preamyloid deposits in Alzheimer's disease, Down syndrome and nondemented elderly individuals.
Progress in clinical and biological research 1989;317():1001-5.
126.
1989

B Frangione

Systemic and cerebral amyloidosis.
Annals of medicine 1989;21(2):69-72.
127.
1988

F Tagliavini; G Giaccone; B Frangione; O Bugiani

Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals.
Neuroscience letters 1988;93(2-3):191-6.
128.
1988

F Coria; F Prelli; E M Castaño; M Larrondo-Lillo; J Fernandez-Gonzalez; S G van Duinen; G T Bots; W Luyendijk; M L Shelanski; B Frangione

Beta-protein deposition: a pathogenetic link between Alzheimer's disease and cerebral amyloid angiopathies.
Brain research 1988;463(1):187-91.
129.
1988

F Prelli; E Castaño; G G Glenner; B Frangione

Differences between vascular and plaque core amyloid in Alzheimer's disease.
Journal of neurochemistry 1988;51(2):648-51.
130.
1988

J Ghiso; N Cowan; B Frangione

Isolation of a sequence encoding human cystatin C. Conservation of exon-intron structure between members of the cysteine proteinase inhibitors superfamily.
Biological chemistry Hoppe-Seyler 1988;369 Suppl():205-8.
131.
1988

F Coria; E Castaño; F Prelli; M Larrondo-Lillo; S van Duinen; M L Shelanski; B Frangione

Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis.
Laboratory investigation; a journal of technical methods and pathology 1988;58(4):454-8.
132.
1988

F Prelli; E M Castaño; S G van Duinen; G T Bots; W Luyendijk; B Frangione

Different processing of Alzheimer's beta-protein precursor in the vessel wall of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type.
Biochemical and biophysical research communications 1988;151(3):1150-5.
133.
1988

E M Castaño; B Frangione

Human amyloidosis, Alzheimer disease and related disorders.
Laboratory investigation; a journal of technical methods and pathology 1988;58(2):122-32.
134.
1987

F Prelli; M Pras; B Frangione

Degradation and deposition of amyloid AA fibrils are tissue specific.
Biochemistry 1987;26(25):8251-6.
135.
1987

A H Warfel; D Zucker-Franklin; B Frangione; J Ghiso

Constitutive secretion of cystatin C (gamma-trace) by monocytes and macrophages and its downregulation after stimulation.
The Journal of experimental medicine 1987;166(6):1912-7.
136.
1987

F Coria; E M Castaño; B Frangione

Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein.
The American journal of pathology 1987;129(3):422-8.
137.
1987

P D Gorevic; E M Castano; R Sarma; B Frangione

Ten to fourteen residue peptides of Alzheimer's disease protein are sufficient for amyloid fibril formation and its characteristic x-ray diffraction pattern.
Biochemical and biophysical research communications 1987;147(2):854-62.
138.
1987

S G van Duinen; E M Castaño; F Prelli; G T Bots; W Luyendijk; B Frangione

Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(16):5991-4.
139.
1986

P D Gorevic; F Goñi; B Pons-Estel; F Alvarez; N S Peress; B Frangione

Isolation and partial characterization of neurofibrillary tangles and amyloid plaque core in Alzheimer's disease: immunohistological studies.
Journal of neuropathology and experimental neurology 1986;45(6):647-64.
140.
1986

J Ghiso; O Jensson; B Frangione

Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C).
Proceedings of the National Academy of Sciences of the United States of America 1986;83(9):2974-8.
141.
1986

J Ghiso; B Pons-Estel; B Frangione

Hereditary cerebral amyloid angiopathy: the amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases.
Biochemical and biophysical research communications 1986;136(2):548-54.

Scientific Context

This section shows information that has been computed by using the fingerprint of the grant, including related publications, related experts and related grants - all with fingerprints representing significant amounts of overlap between their fingerprint and this grant. The red dots indicate whether those experts or terms actually appear within this grant, showing potential and actual connections.

Related Grants

Related Publications

Related Experts
Author of this Publication

Internal Experts

Publications