Iwatsubo, Takeshi

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Interdisciplinary Approach to Alzheimer Drug Discovery

Gandy, Samuel E

30 September 1991 - 31 August 2010
NATIONAL INSTITUTE ON AGING
Total Funding: $ 11,063,275

144 Resulting Publications

• 1.

  2013

  Patrick Holton; Mina Ryten; Michael Nalls; Daniah Trabzuni; Michael E Weale; Dena Hernandez; Helen Crehan; J Raphael Gibbs; Richard Mayeux; Jonathan L Haines; et al.

  Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.

  Annals of human genetics 2013;77(2):85-105.

• 2.

  2012

  Gyungah Jun; Badri N Vardarajan; Jacqueline Buros; Chang-En Yu; Michele V Hawk; Beth A Dombroski; Paul K Crane; Eric B Larson; ; Richard Mayeux; et al.

  Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.

  Archives of neurology 2012;69(10):1270-9.

• 3.

  2012

  Guiqing Cai; Gil Atzmon; Adam C Naj; Gary W Beecham; Nir Barzilai; Jonathan L Haines; Mary Sano; Margaret Pericak-Vance; Joseph D Buxbaum

  Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease.

  Neurobiology of aging 2012;33(2):416-417.e3.

• 4.

  2012

  Fanggeng Zou; High Seng Chai; Curtis S Younkin; Mariet Allen; Julia Crook; V Shane Pankratz; Minerva M Carrasquillo; Christopher N Rowley; Asha A Nair; Sumit Middha; et al.

  Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.

  PLoS genetics 2012;8(6):e1002707.

• 5.

  2012

  H R Sohrabi; K A Bates; M G Weinborn; A N B Johnston; A Bahramian; K Taddei; S M Laws; M Rodrigues; M Morici; M Howard; et al.

  Olfactory discrimination predicts cognitive decline among community-dwelling older adults.

  Translational psychiatry 2012;2():e118.

• 6.

  2012

  Prashant R Bharadwaj; Giuseppe Verdile; Renae K Barr; Veer Gupta; John W Steele; M Lenard Lachenmayer; Zhenyu Yue; Michelle E Ehrlich; Gregory Petsko; Shulin Ju; et al.

  Latrepirdine (Dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.

  Journal of Alzheimer's disease : JAD 2012;32(4):949-67.

• 7.

  2012

  Hannah Brautigam; John W Steele; David Westaway; Paul E Fraser; Peter H St George-Hyslop; Sam Gandy; Patrick R Hof; Dara L Dickstein

  The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease.

  Molecular neurodegeneration 2012;7():58.

• 8.

  2011

  Markus Britschgi; Kaspar Rufibach; Sarah L Bauer Huang; Christopher M Clark; Jeffrey A Kaye; Ge Li; Elaine R Peskind; Joseph F Quinn; Douglas R Galasko; Tony Wyss-Coray

  Modeling of pathological traits in Alzheimer's disease based on systemic extracellular signaling proteome.

  Molecular & cellular proteomics : MCP 2011;10(10):M111.008862.

• 9.

  2011

  Saori Hata; Sayaka Fujishige; Yoichi Araki; Miyako Taniguchi; Katsuya Urakami; Elaine Peskind; Hiroyasu Akatsu; Masahiko Araseki; Kazuo Yamamoto; Ralph N Martins; et al.

  Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.

  Annals of neurology 2011;69(6):1026-31.

• 10.

  2011

  Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; et al.

  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

  Nature genetics 2011;43(5):436-41.

• 11.

  2011

  John W Steele; Sam Gandy

  Apomorphine and Alzheimer Aβ: roles for regulated α cleavage, autophagy, and antioxidation?

  Annals of neurology 2011;69(2):221-5.

• 12.

  2011

  Sam Gandy; Brandon Wustman

  New pathway links γ-secretase to inflammation and memory while sparing notch.

  Annals of neurology 2011;69(1):5-7.

• 13.

  2010

  Gary W Beecham; Adam C Naj; John R Gilbert; Jonathan L Haines; Joseph D Buxbaum; Margaret A Pericak-Vance

  PCDH11X variation is not associated with late-onset Alzheimer disease susceptibility.

  Psychiatric genetics 2010;20(6):321-4.

• 14.

  2010

  Gyungah Jun; Adam C Naj; Gary W Beecham; Li-San Wang; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Nilufer Ertekin-Taner; M Daniele Fallin; Robert Friedland; et al.

  Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.

  Archives of neurology 2010;67(12):1473-84.

• 15.

  2010

  Steven T DeKosky; Milos D Ikonomovic; Sam Gandy

  Traumatic brain injury--football, warfare, and long-term effects.

  The New England journal of medicine 2010;363(14):1293-6.

• 16.

  2010

  Rachel F Lane; Summer M Raines; John W Steele; Michelle E Ehrlich; James A Lah; Scott A Small; Rudolph E Tanzi; Alan D Attie; Sam Gandy

  Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(39):13110-5.

• 17.

  2010

  Adam C Naj; Gary W Beecham; Eden R Martin; Paul J Gallins; Eric H Powell; Ioanna Konidari; Patrice L Whitehead; Guiqing Cai; Vahram Haroutunian; William K Scott; et al.

  Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.

  PLoS genetics 2010;6(9):.

• 18.

  2010

  A M Jenner; W L F Lim; M P E Ng; M R Wenk; G Shui; M J Sharman; S E Gandy; R N Martins

  The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice.

  Neuroscience 2010;169(1):109-15.

• 19.

  2010

  Sam Gandy; Adam J Simon; John W Steele; Alex L Lublin; James J Lah; Lary C Walker; Allan I Levey; Grant A Krafft; Efrat Levy; Frédéric Checler; et al.

  Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers.

  Annals of neurology 2010;68(2):220-30.

• 20.

  2010

  Sam Gandy

  Testing the amyloid hypothesis of Alzheimer's disease in vivo.

  Lancet neurology 2010;9(4):333-5.

• 21.

  2010

  Yasushi Tomidokoro; Agueda Rostagno; Thomas A Neubert; Yun Lu; G William Rebeck; Blas Frangione; Steven M Greenberg; Jorge Ghiso

  Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits.

  The American journal of pathology 2010;176(4):1841-54.

• 22.

  2010

  Soong Ho Kim; Paul E Fraser; David Westaway; Peter H St George-Hyslop; Michelle E Ehrlich; Sam Gandy

  Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(11):3870-5.

• 23.

  2010

  Miguel A Gama Sosa; Rita De Gasperi; Anne B Rocher; Athena Ching-Jung Wang; William G M Janssen; Tony Flores; Gissel M Perez; James Schmeidler; Dara L Dickstein; Patrick R Hof; et al.

  Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations.

  The American journal of pathology 2010;176(1):353-68.

• 24.

  2010

  Dara L Dickstein; Jessica Walsh; Hannah Brautigam; Steven D Stockton; Samuel Gandy; Patrick R Hof

  Role of vascular risk factors and vascular dysfunction in Alzheimer's disease.

  The Mount Sinai journal of medicine, New York 2010;77(1):82-102.

• 25.

  2010

  Alex L Lublin; Sam Gandy

  Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's Disease.

  The Mount Sinai journal of medicine, New York 2010;77(1):43-9.

• 26.

  2010

  Matthew J Sharman; Guanghou Shui; Aaron Z Fernandis; Wei Ling F Lim; Tamar Berger; Eugene Hone; Kevin Taddei; Ian J Martins; Jorge Ghiso; Joseph D Buxbaum; et al.

  Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry.

  Journal of Alzheimer's disease : JAD 2010;20(1):105-11.

• 27.

  2010

  Yuji Kajiwara; Sonia Franciosi; Nagahide Takahashi; Lisa Krug; James Schmeidler; Kevin Taddei; Vahram Haroutunian; Ulrik Fried; Michelle Ehrlich; Ralph N Martins; et al.

  Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease.

  Molecular neurodegeneration 2010;5():1.

• 28.

  2010

  Matthew J Sharman; Michael Morici; Eugene Hone; Tamar Berger; Kevin Taddei; Ian J Martins; Wei Ling F Lim; Sajla Singh; Markus R Wenk; Jorge Ghiso; et al.

  APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice.

  Journal of Alzheimer's disease : JAD 2010;21(2):403-9.

• 29.

  2010

  Sandra I Vieira; Sandra Rebelo; Hermann Esselmann; Jens Wiltfang; James Lah; Rachel Lane; Scott A Small; Sam Gandy; Edgar F da Cruz E Silva; Odete Ab da Cruz E Silva

  Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.

  Molecular neurodegeneration 2010;5():40.

• 30.

  2009

  Saori Hata; Sayaka Fujishige; Yoichi Araki; Naoko Kato; Masahiko Araseki; Masaki Nishimura; Dieter Hartmann; Paul Saftig; Falk Fahrenholz; Miyako Taniguchi; et al.

  Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.

  The Journal of biological chemistry 2009;284(52):36024-33.

• 31.

  2009

  Dan Kaufer; Sam Gandy

  APOE {epsilon}4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics.

  Neurology 2009;73(24):2052-3.

• 32.

  2009

  Stefan A Grathwohl; Roland E Kälin; Tristan Bolmont; Stefan Prokop; Georg Winkelmann; Stephan A Kaeser; Jörg Odenthal; Rebecca Radde; Therese Eldh; Sam Gandy; et al.

  Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.

  Nature neuroscience 2009;12(11):1361-3.

• 33.

  2009

  Saravanan S Karuppagounder; Hui Xu; Qingli Shi; Lian H Chen; Steve Pedrini; David Pechman; Harriet Baker; M Flint Beal; Sam E Gandy; Gary E Gibson

  Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.

  Neurobiology of aging 2009;30(10):1587-600.

• 34.

  2009

  Andreas Aslund; Christina J Sigurdson; Therése Klingstedt; Stefan Grathwohl; Tristan Bolmont; Dara L Dickstein; Eirik Glimsdal; Stefan Prokop; Mikael Lindgren; Peter Konradsson; et al.

  Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses.

  ACS chemical biology 2009;4(8):673-84.

• 35.

  2009

  M Britschgi; C E Olin; H T Johns; Y Takeda-Uchimura; M C LeMieux; K Rufibach; J Rajadas; H Zhang; B Tomooka; W H Robinson; et al.

  Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.

  Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12145-50.

• 36.

  2009

  Tamas Revesz; Janice L Holton; Tammaryn Lashley; Gordon Plant; Blas Frangione; Agueda Rostagno; Jorge Ghiso

  Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies.

  Acta neuropathologica 2009;118(1):115-30.

• 37.

  2009

  E C Mormino; J T Kluth; C M Madison; G D Rabinovici; S L Baker; B L Miller; R A Koeppe; C A Mathis; M W Weiner; W J Jagust; et al.

  Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects.

  Brain : a journal of neurology 2009;132(Pt 5):1310-23.

• 38.

  2009

  Clifford R Jack; Val J Lowe; Stephen D Weigand; Heather J Wiste; Matthew L Senjem; David S Knopman; Maria M Shiung; Jeffrey L Gunter; Bradley F Boeve; Bradley J Kemp; et al.

  Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease.

  Brain : a journal of neurology 2009;132(Pt 5):1355-65.

• 39.

  2009

  Samuel Gandy

  An interview with Samuel Gandy, MD, PhD: Alzheimer's disease by Norman Sussman.

  CNS spectrums 2009;14(5):248-51.

• 40.

  2009

  Megumi Sakuma; Emi Tanaka; Hidenori Taru; Susumu Tomita; Sam Gandy; Angus C Nairn; Tadashi Nakaya; Tohru Yamamoto; Toshiharu Suzuki

  Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP.

  Journal of neurochemistry 2009;109(2):465-75.

• 41.

  2009

  Odete A B da Cruz e Silva; Sandra Rebelo; Sandra I Vieira; Sam Gandy; Edgar F da Cruz e Silva; Paul Greengard

  Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C.

  Journal of neurochemistry 2009;108(2):319-30.

• 42.

  2009

  Marialaura Amadio; Alessia Pascale; Jun Wang; Lap Ho; Alessandro Quattrone; Sam Gandy; Vahram Haroutunian; Marco Racchi; Giulio Maria Pasinetti

  nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing.

  Journal of Alzheimer's disease : JAD 2009;16(2):409-19.

• 43.

  2009

  Yuji Kajiwara; Afia Akram; Pavel Katsel; Vahram Haroutunian; James Schmeidler; Gary Beecham; Jonathan L Haines; Margaret A Pericak-Vance; Joseph D Buxbaum

  FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

  PloS one 2009;4(4):e5071.

• 44.

  2009

  Kristyn A Bates; Hamid R Sohrabi; Mark Rodrigues; John Beilby; Satvinder S Dhaliwal; Kevin Taddei; Arthur Criddle; Megan Wraith; Matthew Howard; Georgia Martins; et al.

  Association of cardiovascular factors and Alzheimer's disease plasma amyloid-beta protein in subjective memory complainers.

  Journal of Alzheimer's disease : JAD 2009;17(2):305-18.

• 45.

  2009

  Hamid R Sohrabi; Kristyn A Bates; Mark Rodrigues; Kevin Taddei; Simon M Laws; Nicola T Lautenschlager; Satvinder S Dhaliwal; Amy N B Johnston; Alan Mackay-Sim; Samuel Gandy; et al.

  Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals.

  Journal of Alzheimer's disease : JAD 2009;17(1):135-42.

• 46.

  2009

  Steve Pedrini; Carlos Thomas; Hannah Brautigam; James Schmeidler; Lap Ho; Paul Fraser; David Westaway; Peter St George Hyslop; Ralph N Martins; Joseph D Buxbaum; et al.

  Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology.

  Molecular neurodegeneration 2009;4():40.

• 47.

  2009

  Sonia Franciosi; Miguel A Gama Sosa; Daniel F English; Elizabeth Oler; Twethida Oung; William Gm Janssen; Rita De Gasperi; James Schmeidler; Dara L Dickstein; Christoph Schmitz; et al.

  Novel cerebrovascular pathology in mice fed a high cholesterol diet.

  Molecular neurodegeneration 2009;4():42.

• 48.

  2009

  John W Steele; Soong H Kim; John R Cirrito; Deborah K Verges; Jessica L Restivo; David Westaway; Paul Fraser; Peter St George Hyslop; Mary Sano; Ilya Bezprozvanny; et al.

  Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo.

  Molecular neurodegeneration 2009;4():51.

• 49.

  2008

  Yuhki Saito; Yoshitake Sano; Robert Vassar; Sam Gandy; Tadashi Nakaya; Tohru Yamamoto; Toshiharu Suzuki

  X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.

  The Journal of biological chemistry 2008;283(51):35763-71.

• 50.

  2008

  Weiping Qin; Wei Zhao; Lap Ho; Jun Wang; Kenneth Walsh; Sam Gandy; Giulio Maria Pasinetti

  Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration.

  Annals of the New York Academy of Sciences 2008;1147():335-47.

• 51.

  2008

  T Lashley; T Revesz; G Plant; R Bandopadhyay; A J Lees; B Frangione; N W Wood; R de Silva; J Ghiso; A Rostagno; et al.

  Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease.

  Neuropathology and applied neurobiology 2008;34(5):492-505.

• 52.

  2008

  M S Beeri; J Schmeidler; J M Silverman; S Gandy; M Wysocki; C M Hannigan; D P Purohit; G Lesser; H T Grossman; V Haroutunian

  Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology.

  Neurology 2008;71(10):750-7.

• 53.

  2008

  Anastazija Gnjec; Katarzyna J D'Costa; Simon M Laws; Ross Hedley; Kelvin Balakrishnan; Kevin Taddei; Georgia Martins; Athena Paton; Giuseppe Verdile; Samuel E Gandy; et al.

  Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease.

  Journal of neuroinflammation 2008;5():36.

• 54.

  2007

  Sam Gandy; Yun-wu Zhang; Annat Ikin; Stephen D Schmidt; Alexey Bogush; Efrat Levy; Roxanne Sheffield; Ralph A Nixon; Francesca-Fang Liao; Paul M Mathews; et al.

  Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.

  Journal of neurochemistry 2007;102(3):619-26.

• 55.

  2007

  Agueda Rostagno; Tammaryn Lashley; Douglas Ng; Jordana Meyerson; Hans Braendgaard; Gordon Plant; Marie Bojsen-Møller; Janice Holton; Blas Frangione; Tamas Revesz; et al.

  Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease.

  Journal of the neurological sciences 2007;257(1-2):88-96.

• 56.

  2007

  Sonia Franciosi; Rita De Gasperi; Dara L Dickstein; Daniel F English; Anne B Rocher; William G M Janssen; Daniel Christoffel; Miguel A Gama Sosa; Patrick R Hof; Joseph D Buxbaum; et al.

  Pepsin pretreatment allows collagen IV immunostaining of blood vessels in adult mouse brain.

  Journal of neuroscience methods 2007;163(1):76-82.

• 57.

  2007

  Giuseppe Verdile; Samuel E Gandy; Ralph N Martins

  The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid.

  Neurochemical research 2007;32(4-5):609-23.

• 58.

  2007

  Annat F Ikin; Mirsada Causevic; Steve Pedrini; Lyndsey S Benson; Joseph D Buxbaum; Toshiharu Suzuki; Simon Lovestone; Shigeki Higashiyama; Tomas Mustelin; Robert D Burgoyne; et al.

  Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding.

  Molecular neurodegeneration 2007;2():23.

• 59.

  2006

  Weiping Qin; Mark Chachich; Mark Lane; George Roth; Mark Bryant; Rafael de Cabo; Mary Ann Ottinger; Julie Mattison; Donald Ingram; Samuel Gandy; et al.

  Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus).

  Journal of Alzheimer's disease : JAD 2006;10(4):417-22.

• 60.

  2006

  Scott A Small; Sam Gandy

  Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.

  Neuron 2006;52(1):15-31.

• 61.

  2006

  Sam Gandy; Mark K Doeven; Bert Poolman

  Alzheimer disease: presenilin springs a leak.

  Nature medicine 2006;12(10):1121-3.

• 62.

  2006

  Steven M Greenberg; Jonathan Rosand; Alexander T Schneider; L Creed Pettigrew; Samuel E Gandy; Barry Rovner; Brian-Fred Fitzsimmons; Eric E Smith; M Edip Gurol; Kristin Schwab; et al.

  A phase 2 study of tramiprosate for cerebral amyloid angiopathy.

  Alzheimer disease and associated disorders 2006;20(4):269-74.

• 63.

  2006

  Weiping Qin; Tianle Yang; Lap Ho; Zhong Zhao; Jun Wang; Linghong Chen; Wei Zhao; Meenakshisundaram Thiyagarajan; Donal MacGrogan; Joseph T Rodgers; et al.

  Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.

  The Journal of biological chemistry 2006;281(31):21745-54.

• 64.

  2006

  I J Martins; E Hone; J K Foster; S I Sünram-Lea; A Gnjec; S J Fuller; D Nolan; S E Gandy; R N Martins

  Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease.

  Molecular psychiatry 2006;11(8):721-36.

• 65.

  2006

  Troy L Carter; Steve Pedrini; Jorge Ghiso; Michelle E Ehrlich; Sam Gandy

  Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis.

  Neuroscience letters 2006;392(3):235-9.

• 66.

  2006

  Yoshitake Sano; Tadashi Nakaya; Steve Pedrini; Shizu Takeda; Kanae Iijima-Ando; Koichi Iijima; Paul M Mathews; Shigeyoshi Itohara; Sam Gandy; Toshiharu Suzuki

  Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

  PloS one 2006;1():e51.

• 67.

  2005

  Kelvin Balakrishnan; Giuseppe Verdile; Pankaj D Mehta; John Beilby; David Nolan; Daniel A Galvão; Robert Newton; Samuel E Gandy; Ralph N Martins

  Plasma Abeta42 correlates positively with increased body fat in healthy individuals.

  Journal of Alzheimer's disease : JAD 2005;8(3):269-82.

• 68.

  2005

  Sam Gandy; Frank L Heppner

  Breaking up (amyloid) is hard to do.

  PLoS medicine 2005;2(12):e417.

• 69.

  2005

  Sam Gandy

  Position on stem cell research.

  Neurology 2005;65(9):1512-3; author reply 1512-3.

• 70.

  2005

  Giuseppina Tesco; Andrea Ginestroni; Mikko Hiltunen; Minji Kim; Georgia Dolios; Bradley T Hyman; Rong Wang; Oksana Berezovska; Rudolph E Tanzi

  APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.

  Journal of neurochemistry 2005;95(2):446-56.

• 71.

  2005

  Angeliki Fotinopoulou; Maria Tsachaki; Maria Vlavaki; Alexandros Poulopoulos; Agueda Rostagno; Blas Frangione; Jorge Ghiso; Spiros Efthimiopoulos

  BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.

  The Journal of biological chemistry 2005;280(35):30768-72.

• 72.

  2005

  E Hone; I J Martins; M Jeoung; T H Ji; S E Gandy; R N Martins

  Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding.

  Journal of Alzheimer's disease : JAD 2005;7(4):303-14.

• 73.

  2005

  N T Lautenschlager; Jing-Shan Wu; S M Laws; O P Almeida; R M Clarnette; K Joesbury; S Wagenpfeil; G Martins; A Paton; S E Gandy; et al.

  Neurological soft signs are associated with APOE genotype, age and cognitive performance.

  Journal of Alzheimer's disease : JAD 2005;7(4):325-30.

• 74.

  2005

  Laura Morelli; Ramiro E Llovera; Leonardo G Alonso; Blas Frangione; Gonzalo de Prat-Gay; Jorge Ghiso; Eduardo M Castaño

  Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia.

  Biochemical and biophysical research communications 2005;332(3):808-16.

• 75.

  2005

  Yoshifumi Nakaya; Takuya Yamane; Hirohisa Shiraishi; Hua-Qin Wang; Etsuro Matsubara; Toru Sato; Georgia Dolios; Rong Wang; Bart De Strooper; Mikio Shoji; et al.

  Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.

  The Journal of biological chemistry 2005;280(19):19070-7.

• 76.

  2005

  Sam Gandy

  The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease.

  The Journal of clinical investigation 2005;115(5):1121-9.

• 77.

  2005

  Lary C Walker; Chris C Ibegbu; Charles W Todd; Harriet L Robinson; Mathias Jucker; Harry LeVine; Sam Gandy

  Emerging prospects for the disease-modifying treatment of Alzheimer's disease.

  Biochemical pharmacology 2005;69(7):1001-8.

• 78.

  2005

  Steve Pedrini; Troy L Carter; George Prendergast; Suzana Petanceska; Michelle E Ehrlich; Sam Gandy

  Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK.

  PLoS medicine 2005;2(1):e18.

• 79.

  2004

  Laura Morelli; Ramiro E Llovera; Irina Mathov; Lih-Fen Lue; Blas Frangione; Jorge Ghiso; Eduardo M Castaño

  Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.

  The Journal of biological chemistry 2004;279(53):56004-13.

• 80.

  2004

  Silva Hecimovic; Jun Wang; Georgia Dolios; Maribel Martinez; Rong Wang; Alison M Goate

  Mutations in APP have independent effects on Abeta and CTFgamma generation.

  Neurobiology of disease 2004;17(2):205-18.

• 81.

  2004

  Jorge Ghiso; Marcos Shayo; Miguel Calero; Douglas Ng; Yasushi Tomidokoro; Samuel Gandy; Agueda Rostagno; Blas Frangione

  Systemic catabolism of Alzheimer's Abeta40 and Abeta42.

  The Journal of biological chemistry 2004;279(44):45897-908.

• 82.

  2004

  Patrick C Fraering; Wenjuan Ye; Jean-Marc Strub; Georgia Dolios; Matthew J LaVoie; Beth L Ostaszewski; Alain van Dorsselaer; Rong Wang; Dennis J Selkoe; Michael S Wolfe

  Purification and characterization of the human gamma-secretase complex.

  Biochemistry 2004;43(30):9774-89.

• 83.

  2004

  Etsuro Matsubara; Yoshiki Sekijima; Takahiko Tokuda; Katsuya Urakami; Masakuni Amari; Masami Shizuka-Ikeda; Yasushi Tomidokoro; Masaki Ikeda; Takeshi Kawarabayashi; Yasuo Harigaya; et al.

  Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins.

  Neurobiology of aging 2004;25(7):833-41.

• 84.

  2004

  S Parvathy; Michelle Ehrlich; Steve Pedrini; Nichole Diaz; Lorenzo Refolo; Joseph D Buxbaum; Alexey Bogush; Suzana Petanceska; Sam Gandy

  Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.

  Journal of neurochemistry 2004;90(4):1005-10.

• 85.

  2004

  Jun Yao; Suzana S Petanceska; Thomas J Montine; David M Holtzman; Stephen D Schmidt; Carolyn A Parker; Michael J Callahan; William J Lipinski; Charles L Bisgaier; Brian A Turner; et al.

  Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits.

  Journal of neurochemistry 2004;90(4):1011-8.

• 86.

  2004

  Troy L Carter; Robert A Rissman; Amanda J Mishizen-Eberz; Barry B Wolfe; Ronald L Hamilton; Sam Gandy; David M Armstrong

  Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage.

  Experimental neurology 2004;187(2):299-309.

• 87.

  2004

  Sam Gandy

  Cerebral Abeta amyloidosis and postmenopausal hormone deficiency: roles in the genesis of Alzheimer's disease.

  Human pathology 2004;35(3):271-4.

• 88.

  2003

  Emily J H Lehman; Laura Shapiro Kulnane; Yuan Gao; Michelle C Petriello; Karen M Pimpis; Linda Younkin; Georgia Dolios; Rong Wang; Steven G Younkin; Bruce T Lamb

  Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse.

  Human molecular genetics 2003;12(22):2949-56.

• 89.

  2003

  Christina Lilliehook; Ozlem Bozdagi; Jun Yao; Manuel Gomez-Ramirez; Nikhat F Zaidi; Wilma Wasco; Sam Gandy; Anthony C Santucci; Vahram Haroutunian; George W Huntley; et al.

  Altered Abeta formation and long-term potentiation in a calsenilin knock-out.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(27):9097-106.

• 90.

  2003

  Elizabeth A Thomas; Simon M Laws; J Gregor Sutcliffe; Clive Harper; Brian Dean; Catriona McClean; Colin Masters; Nicola Lautenschlager; Samuel E Gandy; Ralph N Martins

  Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype.

  Biological psychiatry 2003;54(2):136-41.

• 91.

  2003

  Laura Morelli; Ramiro Llovera; Silvia A Gonzalez; Jose L Affranchino; Frances Prelli; Blas Frangione; Jorge Ghiso; Eduardo M Castano

  Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.

  The Journal of biological chemistry 2003;278(26):23221-6.

• 92.

  2003

  Takeshi Ikeuchi; Georgia Dolios; Seong-Hun Kim; Rong Wang; Sangram S Sisodia

  Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

  The Journal of biological chemistry 2003;278(9):7010-8.

• 93.

  2003

  John B J Kwok; Glenda M Halliday; William S Brooks; Georgia Dolios; Hanna Laudon; Ohoshi Murayama; Marianne Hallupp; Renee F Badenhop; James Vickers; Rong Wang; et al.

  Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy.

  The Journal of biological chemistry 2003;278(9):6748-54.

• 94.

  2002

  Jorge Ghiso; Blas Frangione

  Amyloidosis and Alzheimer's disease.

  Advanced drug delivery reviews 2002;54(12):1539-51.

• 95.

  2002

  E Matsubara; M Shoji; T Murakami; K Abe; B Frangione; J Ghiso

  Platelet microparticles as carriers of soluble Alzheimer's amyloid beta (sAbeta).

  Annals of the New York Academy of Sciences 2002;977():340-8.

• 96.

  2002

  Samir Kumar-Singh; Patrick Cras; Rong Wang; John M Kros; Johan van Swieten; Ursula Lübke; Chantal Ceuterick; Sally Serneels; Krist'l Vennekens; Jean-Pierre Timmermans; et al.

  Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric.

  The American journal of pathology 2002;161(2):507-20.

• 97.

  2002

  Philip C Wong; Huaibin Cai; David R Borchelt; Donald L Price

  Genetically engineered mouse models of neurodegenerative diseases.

  Nature neuroscience 2002;5(7):633-9.

• 98.

  2002

  Zhongmin Zhou; Norman Relkin; Jorge Ghiso; Jonathan D Smith; Sam Gandy

  Human cerebrospinal fluid apolipoprotein E isoforms are apparently inefficient at complexing with synthetic Alzheimer's amyloid-[beta] peptide (A[beta] 1-40 ) in vitro.

  Molecular medicine (Cambridge, Mass.) 2002;8(7):376-81.

• 99.

  2002

  Jimin Zhang; Wenjuan Ye; Rong Wang; Michael S Wolfe; Barry D Greenberg; Dennis J Selkoe

  Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.

  The Journal of biological chemistry 2002;277(17):15069-75.

• 100.

  2002

  M Paul Murphy; Sacha N Uljon; Todd E Golde; Rong Wang

  FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants.

  Biochimica et biophysica acta 2002;1586(2):199-209.

• 101.

  2002

  S M Laws; R M Clarnette; K Taddei; G Martins; A Paton; J Hallmayer; O P Almeida; D M Groth; S E Gandy; H Förstl; et al.

  APOE-epsilon4 and APOE -491A polymorphisms in individuals with subjective memory loss.

  Molecular psychiatry 2002;7(7):768-75.

• 102.

  2002

  K Taddei; C Fisher; S M Laws; G Martins; A Paton; R M Clarnette; C Chung; W S Brooks; J Hallmayer; J Miklossy; et al.

  Association between presenilin-1 Glu318Gly mutation and familial Alzheimer's disease in the Australian population.

  Molecular psychiatry 2002;7(7):776-81.

• 103.

  2002

  S M Laws; E Hone; K Taddei; C Harper; B Dean; C McClean; C Masters; N Lautenschlager; S E Gandy; R N Martins

  Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.

  Molecular psychiatry 2002;7(8):886-90.

• 104.

  2001

  S Parvathy; P Davies; V Haroutunian; D P Purohit; K L Davis; R C Mohs; H Park; T M Moran; J Y Chan; J D Buxbaum

  Correlation between Abetax-40-, Abetax-42-, and Abetax-43-containing amyloid plaques and cognitive decline.

  Archives of neurology 2001;58(12):2025-32.

• 105.

  2001

  P C Wong; H Cai; D R Borchelt; D L Price

  Genetically engineered models relevant to neurodegenerative disorders: their value for understanding disease mechanisms and designing/testing experimental therapeutics.

  Journal of molecular neuroscience : MN 2001;17(2):233-57.

• 106.

  2001

  P A Lewis; S Piper; M Baker; L Onstead; M P Murphy; J Hardy; R Wang; E McGowan; T E Golde

  Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides.

  Biochimica et biophysica acta 2001;1537(1):58-62.

• 107.

  2001

  S Gandy; O P Almeida; J Fonte; D Lim; A Waterrus; N Spry; L Flicker; R N Martins

  Chemical andropause and amyloid-beta peptide.

  JAMA : the journal of the American Medical Association 2001;285(17):2195-6.

• 108.

  2000

  M Calero; A Rostagno; E Matsubara; B Zlokovic; B Frangione; J Ghiso

  Apolipoprotein J (clusterin) and Alzheimer's disease.

  Microscopy research and technique 2000;50(4):305-15.

• 109.

  2000

  T Tokuda; M Calero; E Matsubara; R Vidal; A Kumar; B Permanne; B Zlokovic; J D Smith; M J Ladu; A Rostagno; et al.

  Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.

  The Biochemical journal 2000;348 Pt 2():359-65.

• 110.

  1999

  M Calero; T Tokuda; A Rostagno; A Kumar; B Zlokovic; B Frangione; J Ghiso

  Functional and structural properties of lipid-associated apolipoprotein J (clusterin).

  The Biochemical journal 1999;344 Pt 2():375-83.

• 111.

  1999

  J P Greenfield; H Xu; P Greengard; S Gandy; M Seeger

  Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein.

  The Journal of biological chemistry 1999;274(48):33843-6.

• 112.

  1999

  L Lévesque; W Annaert; K Craessaerts; P M Mathews; M Seeger; R A Nixon; F Van Leuven; S Gandy; D Westaway; P St George-Hyslop; et al.

  Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.

  Molecular medicine (Cambridge, Mass.) 1999;5(8):542-54.

• 113.

  1999

  S S Sisodia; S H Kim; G Thinakaran

  Function and dysfunction of the presenilins.

  American journal of human genetics 1999;65(1):7-12.

• 114.

  1998

  D L Price; S S Sisodia

  Mutant genes in familial Alzheimer's disease and transgenic models.

  Annual review of neuroscience 1998;21():479-505.

• 115.

  1997

  T Suzuki; K Ando; T Isohara; M Oishi; G S Lim; Y Satoh; W Wasco; R E Tanzi; A C Nairn; P Greengard; et al.

  Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.

  Biochemistry 1997;36(15):4643-9.

• 116.

  1997

  J B Kwok; K Taddei; M Hallupp; C Fisher; W S Brooks; G A Broe; J Hardy; M J Fulham; G A Nicholson; R Stell; et al.

  Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.

  Neuroreport 1997;8(6):1537-42.

• 117.

  1997

  D S Yang; J D Smith; Z Zhou; S E Gandy; R N Martins

  Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma.

  Journal of neurochemistry 1997;68(2):721-5.

• 118.

  1997

  M Oishi; A C Nairn; A J Czernik; G S Lim; T Isohara; S E Gandy; P Greengard; T Suzuki

  The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.

  Molecular medicine (Cambridge, Mass.) 1997;3(2):111-23.

• 119.

  1996

  M Kaplitt; G K Gouras; H Makimura; J Jovanovic; D Sweeney; P Greengard; N R Relkin; S Gandy

  Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer's disease. Therapeutic implications.

  Annals of the New York Academy of Sciences 1996;802():42-9.

• 120.

  1996

  H Xu; D Sweeney; P Greengard; S Gandy

  Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.

  Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4081-4.

• 121.

  1996

  Z Zhou; J D Smith; P Greengard; S Gandy

  Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E.

  Molecular medicine (Cambridge, Mass.) 1996;2(2):175-80.

• 122.

  1996

  J D Buxbaum; P Greengard

  Regulation of APP processing by intra- and intercellular signals.

  Annals of the New York Academy of Sciences 1996;777():327-31.

• 123.

  1995

  H Xu; P Greengard; S Gandy

  Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.

  The Journal of biological chemistry 1995;270(40):23243-5.

• 124.

  1995

  G Fried; H Q Han; B Meister; T Hökfelt; P Greengard

  Laminin and neuropeptide Y are increased by synapsin transfection in cultured NG108-15 neuroblastoma/glioma hybrid cells.

  Journal of neurochemistry 1995;64(6):2674-80.

• 125.

  1995

  E Matsubara; B Frangione; J Ghiso

  Characterization of apolipoprotein J-Alzheimer's A beta interaction.

  The Journal of biological chemistry 1995;270(13):7563-7.

• 126.

  1994

  A Koudinov; E Matsubara; B Frangione; J Ghiso

  The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma.

  Biochemical and biophysical research communications 1994;205(2):1164-71.

• 127.

  1994

  J Näslund; A Schierhorn; U Hellman; L Lannfelt; A D Roses; L O Tjernberg; J Silberring; S E Gandy; B Winblad; P Greengard

  Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.

  Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8378-82.

• 128.

  1994

  J D Buxbaum; A A Ruefli; C A Parker; A M Cypess; P Greengard

  Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.

  Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4489-93.

• 129.

  1994

  A B Jaffe; C D Toran-Allerand; P Greengard; S E Gandy

  Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein.

  The Journal of biological chemistry 1994;269(18):13065-8.

• 130.

  1994

  J Ghiso; J E Gardella; L Liem; P D Gorevic; B Frangione

  Characterization of a novel processing pathway for Alzheimer's amyloid beta precursor protein.

  Neuroscience letters 1994;171(1-2):213-6.

• 131.

  1994

  S Gandy; G Caporaso; J Buxbaum; B Frangione; P Greengard

  APP processing, A beta-amyloidogenesis, and the pathogenesis of Alzheimer's disease.

  Neurobiology of aging 1994;15(2):253-6.

• 132.

  1994

  T Suzuki; M Oishi; D R Marshak; A J Czernik; A C Nairn; P Greengard

  Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.

  The EMBO journal 1994;13(5):1114-22.

• 133.

  1994

  S Gandy; P Greengard

  Processing of Alzheimer A beta-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease.

  International review of neurobiology 1994;36():29-50.

• 134.

  1993

  J Knops; S Gandy; P Greengard; I Lieberburg; S Sinha

  Serine phosphorylation of the secreted extracellular domain of APP.

  Biochemical and biophysical research communications 1993;197(2):380-5.

• 135.

  1993

  O A da Cruz e Silva; K Iverfeldt; T Oltersdorf; S Sinha; I Lieberburg; T V Ramabhadran; T Suzuki; S S Sisodia; S Gandy; P Greengard

  Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail.

  Neuroscience 1993;57(4):873-7.

• 136.

  1993

  J D Buxbaum; E H Koo; P Greengard

  Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.

  Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9195-8.

• 137.

  1993

  S E Gandy; G L Caporaso; J D Buxbaum; O de Cruz Silva; K Iverfeldt; C Nordstedt; T Suzuki; A J Czernik; A C Nairn; P Greengard

  Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein.

  Annals of the New York Academy of Sciences 1993;695():117-21.

• 138.

  1993

  K Iverfeldt; S I Walaas; P Greengard

  Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration.

  Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4146-50.

• 139.

  1993

  T V Ramabhadran; S E Gandy; J Ghiso; A J Czernik; D Ferris; R Bhasin; D Goldgaber; B Frangione; P Greengard

  Proteolytic processing of human amyloid beta protein precursor in insect cells. Major carboxyl-terminal fragment is identical to its human counterpart.

  The Journal of biological chemistry 1993;268(3):2009-12.

• 140.

  1992

  S E Gandy; G L Caporaso; T V Ramabhadran; T Suzuki; J D Buxbaum; C Nordstedt; K Iverfeldt; A J Czernik; A C Nairn; P Greengard

  Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine.

  Annals of the New York Academy of Sciences 1992;674():203-17.

• 141.

  1992

  J Ghiso; A Rostagno; J E Gardella; L Liem; P D Gorevic; B Frangione

  A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion.

  The Biochemical journal 1992;288 ( Pt 3)():1053-9.

• 142.

  1992

  J D Buxbaum; M Oishi; H I Chen; R Pinkas-Kramarski; E A Jaffe; S E Gandy; P Greengard

  Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

  Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10075-8.

• 143.

  1992

  S E Gandy; J D Buxbaum; T Suzuki; T V Ramabhadran; G L Caporaso; A C Nairn; P Greengard

  The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer beta/A4-amyloid precursor protein: some technical notes.

  Neurobiology of aging 1992;13(5):601-3.

• 144.

  1992

  T Suzuki; A C Nairn; S E Gandy; P Greengard

  Phosphorylation of Alzheimer amyloid precursor protein by protein kinase C.

  Neuroscience 1992;48(4):755-61.

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