Frangione, Blas

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Amyloidosis and Alzheimer's Disease

Frangione, Blas

1 July 1985 - 30 June 2007
NATIONAL INSTITUTE ON AGING
Total Funding: $ 4,467,436

141 Resulting Publications

• 1.

  2010

  Yasushi Tomidokoro; Agueda Rostagno; Thomas A Neubert; Yun Lu; G William Rebeck; Blas Frangione; Steven M Greenberg; Jorge Ghiso

  Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits.

  The American journal of pathology 2010;176(4):1841-54.

• 2.

  2009

  Stéphanie G Trouche; Ayodeji Asuni; Sylvie Rouland; Thomas Wisniewski; Blas Frangione; Jean-Michel Verdier; Einar M Sigurdsson; Nadine Mestre-Francés

  Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives.

  Vaccine 2009;27(7):957-64.

• 3.

  2009

  Allal Boutajangout; Fernando Goni; Elin Knudsen; Fernanda Schreiber; Ayodeji Asuni; David Quartermain; Blas Frangione; Alejandro Chabalgoity; Thomas Wisniewski; Einar M Sigurdsson

  Diminished amyloid-beta burden in Tg2576 mice following a prophylactic oral immunization with a salmonella-based amyloid-beta derivative vaccine.

  Journal of Alzheimer's disease : JAD 2009;18(4):961-72.

• 4.

  2008

  T Lashley; T Revesz; G Plant; R Bandopadhyay; A J Lees; B Frangione; N W Wood; R de Silva; J Ghiso; A Rostagno; et al.

  Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease.

  Neuropathology and applied neurobiology 2008;34(5):492-505.

• 5.

  2007

  Agueda Rostagno; Tammaryn Lashley; Douglas Ng; Jordana Meyerson; Hans Braendgaard; Gordon Plant; Marie Bojsen-Møller; Janice Holton; Blas Frangione; Tamas Revesz; et al.

  Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease.

  Journal of the neurological sciences 2007;257(1-2):88-96.

• 6.

  2006

  Ayodeji A Asuni; Allal Boutajangout; Henrieta Scholtzova; Elin Knudsen; Yong Sheng Li; David Quartermain; Blas Frangione; Thomas Wisniewski; Einar M Sigurdsson

  Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages.

  The European journal of neuroscience 2006;24(9):2530-42.

• 7.

  2006

  T Lashley; J L Holton; M M Verbeek; A Rostagno; M Bojsen-Møller; G David; J van Horssen; H Braendgaard; G Plant; B Frangione; et al.

  Molecular chaperons, amyloid and preamyloid lesions in the BRI2 gene-related dementias: a morphological study.

  Neuropathology and applied neurobiology 2006;32(5):492-504.

• 8.

  2006

  María C Leal; Verónica B Dorfman; Agata Fernández Gamba; Blas Frangione; Thomas Wisniewski; Eduardo M Castaño; Einar M Sigurdsson; Laura Morelli

  Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology.

  Journal of neuropathology and experimental neurology 2006;65(10):976-87.

• 9.

  2006

  J Ghiso; A Rostagno; Y Tomidokoro; T Lashley; M Bojsen-Møller; H Braendgaard; G Plant; J Holton; R Lal; T Revesz; et al.

  Genetic alterations of the BRI2 gene: familial British and Danish dementias.

  Brain pathology (Zurich, Switzerland) 2006;16(1):71-9.

• 10.

  2006

  Efrat Levy; Frances Prelli; Blas Frangione

  Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant.

  Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):329-39.

• 11.

  2005

  Yasushi Tomidokoro; Tammaryn Lashley; Agueda Rostagno; Thomas A Neubert; Marie Bojsen-Møller; Hans Braendgaard; Gordon Plant; Janice Holton; Blas Frangione; Tamas Révész; et al.

  Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques.

  The Journal of biological chemistry 2005;280(44):36883-94.

• 12.

  2005

  Angeliki Fotinopoulou; Maria Tsachaki; Maria Vlavaki; Alexandros Poulopoulos; Agueda Rostagno; Blas Frangione; Jorge Ghiso; Spiros Efthimiopoulos

  BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.

  The Journal of biological chemistry 2005;280(35):30768-72.

• 13.

  2005

  Shuji Matsuda; Luca Giliberto; Yukiko Matsuda; Peter Davies; Eileen McGowan; Fiona Pickford; Jorge Ghiso; Blas Frangione; Luciano D'Adamio

  The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.

  The Journal of biological chemistry 2005;280(32):28912-6.

• 14.

  2005

  A Rostagno; Y Tomidokoro; T Lashley; D Ng; G Plant; J Holton; B Frangione; T Revesz; J Ghiso

  Chromosome 13 dementias.

  Cellular and molecular life sciences : CMLS 2005;62(16):1814-25.

• 15.

  2005

  Arjan Quist; Ivo Doudevski; Hai Lin; Rushana Azimova; Douglas Ng; Blas Frangione; Bruce Kagan; Jorge Ghiso; Ratnesh Lal

  Amyloid ion channels: a common structural link for protein-misfolding disease.

  Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10427-32.

• 16.

  2005

  Laura Morelli; Ramiro E Llovera; Leonardo G Alonso; Blas Frangione; Gonzalo de Prat-Gay; Jorge Ghiso; Eduardo M Castaño

  Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia.

  Biochemical and biophysical research communications 2005;332(3):808-16.

• 17.

  2005

  Miguel Calero; Agueda Rostagno; Blas Frangione; Jorge Ghiso

  Clusterin and Alzheimer's disease.

  Sub-cellular biochemistry 2005;38():273-98.

• 18.

  2005

  Thomas Wisniewski; Blas Frangione

  Immunological and anti-chaperone therapeutic approaches for Alzheimer disease.

  Brain pathology (Zurich, Switzerland) 2005;15(1):72-7.

• 19.

  2004

  Laura Morelli; Ramiro E Llovera; Irina Mathov; Lih-Fen Lue; Blas Frangione; Jorge Ghiso; Eduardo M Castaño

  Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.

  The Journal of biological chemistry 2004;279(53):56004-13.

• 20.

  2004

  Jorge Ghiso; Marcos Shayo; Miguel Calero; Douglas Ng; Yasushi Tomidokoro; Samuel Gandy; Agueda Rostagno; Blas Frangione

  Systemic catabolism of Alzheimer's Abeta40 and Abeta42.

  The Journal of biological chemistry 2004;279(44):45897-908.

• 21.

  2004

  Etsuro Matsubara; Yoshiki Sekijima; Takahiko Tokuda; Katsuya Urakami; Masakuni Amari; Masami Shizuka-Ikeda; Yasushi Tomidokoro; Masaki Ikeda; Takeshi Kawarabayashi; Yasuo Harigaya; et al.

  Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins.

  Neurobiology of aging 2004;25(7):833-41.

• 22.

  2004

  Einar M Sigurdsson; Elin Knudsen; Ayodeji Asuni; Cheryl Fitzer-Attas; Daniel Sage; David Quartermain; Fernando Goni; Blas Frangione; Thomas Wisniewski

  An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(28):6277-82.

• 23.

  2003

  Tamas Revesz; Jorge Ghiso; Tammaryn Lashley; Gordon Plant; Agueda Rostagno; Blas Frangione; Janice L Holton

  Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view.

  Journal of neuropathology and experimental neurology 2003;62(9):885-98.

• 24.

  2002

  Jorge Ghiso; Blas Frangione

  Amyloidosis and Alzheimer's disease.

  Advanced drug delivery reviews 2002;54(12):1539-51.

• 25.

  2002

  Einar M Sigurdsson; Thomas Wisniewski; Blas Frangione

  A safer vaccine for Alzheimer's disease?

  Neurobiology of aging 2002;23(6):1001-8.

• 26.

  2002

  Einar M Sigurdsson; David R Brown; Maki Daniels; Richard J Kascsak; Regina Kascsak; Richard Carp; Harry C Meeker; Blas Frangione; Thomas Wisniewski

  Immunization delays the onset of prion disease in mice.

  The American journal of pathology 2002;161(1):13-7.

• 27.

  2002

  Tamas Revesz; Janice L Holton; Tammaryn Lashley; Gordon Plant; Agueda Rostagno; Jorge Ghiso; Blas Frangione

  Sporadic and familial cerebral amyloid angiopathies.

  Brain pathology (Zurich, Switzerland) 2002;12(3):343-57.

• 28.

  2002

  Jasmina B Mackic; James Bading; Jorge Ghiso; Larry Walker; Thomas Wisniewski; Blas Frangione; Berislav V Zlokovic

  Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.

  Vascular pharmacology 2002;38(6):303-13.

• 29.

  2002

  O R Monro; J B Mackic; S Yamada; M B Segal; J Ghiso; C Maurer; M Calero; B Frangione; B V Zlokovic

  Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood.

  Neurobiology of aging 2002;23(3):405-12.

• 30.

  2002

  Janice L Holton; Tammaryn Lashley; Jorge Ghiso; Hans Braendgaard; Ruben Vidal; Christopher J Guerin; Graham Gibb; Diane P Hanger; Agueda Rostagno; Brian H Anderton; et al.

  Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.

  Journal of neuropathology and experimental neurology 2002;61(3):254-67.

• 31.

  2001

  B Poeggeler; L Miravalle; M G Zagorski; T Wisniewski; Y J Chyan; Y Zhang; H Shao; T Bryant-Thomas; R Vidal; B Frangione; et al.

  Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide.

  Biochemistry 2001;40(49):14995-5001.

• 32.

  2001

  J Ghiso; T Révész; J Holton; A Rostagno; T Lashley; H Houlden; G Gibb; B Anderton; T Bek; M Bojsen-Møller; et al.

  Chromosome 13 dementia syndromes as models of neurodegeneration.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8(4):277-84.

• 33.

  2001

  J A Ghiso; J Holton; L Miravalle; M Calero; T Lashley; R Vidal; H Houlden; N Wood; T A Neubert; A Rostagno; et al.

  Systemic amyloid deposits in familial British dementia.

  The Journal of biological chemistry 2001;276(47):43909-14.

• 34.

  2001

  E M Sigurdsson; H Scholtzova; P D Mehta; B Frangione; T Wisniewski

  Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.

  The American journal of pathology 2001;159(2):439-47.

• 35.

  2001

  B Frangione; T Révész; R Vidal; J Holton; T Lashley; H Houlden; N Wood; A Rostagno; G Plant; J Ghiso

  Familial cerebral amyloid angiopathy related to stroke and dementia.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8 Suppl 1():36-42.

• 36.

  2001

  M Calero; M Pawlik; C Soto; E M Castaño; E M Sigurdsson; A Kumar; G Gallo; B Frangione; E Levy

  Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type.

  Journal of neurochemistry 2001;77(2):628-37.

• 37.

  2001

  R Vidal; M Calero; T Révész; G Plant; J Ghiso; B Frangione

  Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family.

  Gene 2001;266(1-2):95-102.

• 38.

  2001

  J L Holton; J Ghiso; T Lashley; A Rostagno; C J Guerin; G Gibb; H Houlden; H Ayling; L Martinian; B H Anderton; et al.

  Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia.

  The American journal of pathology 2001;158(2):515-26.

• 39.

  2000

  M Shibata; S Yamada; S R Kumar; M Calero; J Bading; B Frangione; D M Holtzman; C A Miller; D K Strickland; J Ghiso; et al.

  Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.

  The Journal of clinical investigation 2000;106(12):1489-99.

• 40.

  2000

  R Vidal; J Ghiso; B Frangione

  New familial forms of cerebral amyloid and dementia.

  Molecular psychiatry 2000;5(6):575-6.

• 41.

  2000

  L Miravalle; T Tokuda; R Chiarle; G Giaccone; O Bugiani; F Tagliavini; B Frangione; J Ghiso

  Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

  The Journal of biological chemistry 2000;275(35):27110-6.

• 42.

  2000

  M Calero; A Rostagno; E Matsubara; B Zlokovic; B Frangione; J Ghiso

  Apolipoprotein J (clusterin) and Alzheimer's disease.

  Microscopy research and technique 2000;50(4):305-15.

• 43.

  2000

  T Tokuda; M Calero; E Matsubara; R Vidal; A Kumar; B Permanne; B Zlokovic; J D Smith; M J Ladu; A Rostagno; et al.

  Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.

  The Biochemical journal 2000;348 Pt 2():359-65.

• 44.

  2000

  S Mead; M James-Galton; T Revesz; R B Doshi; G Harwood; E L Pan; J Ghiso; B Frangione; G Plant

  Familial British dementia with amyloid angiopathy: early clinical, neuropsychological and imaging findings.

  Brain : a journal of neurology 2000;123 ( Pt 5)():975-91.

• 45.

  2000

  R Vidal; T Revesz; A Rostagno; E Kim; J L Holton; T Bek; M Bojsen-Møller; H Braendgaard; G Plant; J Ghiso; et al.

  A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred.

  Proceedings of the National Academy of Sciences of the United States of America 2000;97(9):4920-5.

• 46.

  2000

  E M Sigurdsson; B Permanne; C Soto; T Wisniewski; B Frangione

  In vivo reversal of amyloid-beta lesions in rat brain.

  Journal of neuropathology and experimental neurology 2000;59(1):11-7.

• 47.

  2000

  B Frangione; R Vidal; A Rostagno; J Ghiso

  Familial cerebral amyloid angiopathies and dementia.

  Alzheimer disease and associated disorders 2000;14 Suppl 1():S25-30.

• 48.

  1999

  M Calero; T Tokuda; A Rostagno; A Kumar; B Zlokovic; B Frangione; J Ghiso

  Functional and structural properties of lipid-associated apolipoprotein J (clusterin).

  The Biochemical journal 1999;344 Pt 2():375-83.

• 49.

  1999

  A Rostagno; R Vidal; B Kaplan; J Chuba; A Kumar; J I Elliott; B Frangione; G Gallo; J Ghiso

  pH-dependent fibrillogenesis of a VkappaIII Bence Jones protein.

  British journal of haematology 1999;107(4):835-43.

• 50.

  1999

  Y J Chyan; B Poeggeler; R A Omar; D G Chain; B Frangione; J Ghiso; M A Pappolla

  Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid.

  The Journal of biological chemistry 1999;274(31):21937-42.

• 51.

  1999

  J F Poduslo; G L Curran; A Kumar; B Frangione; C Soto

  Beta-sheet breaker peptide inhibitor of Alzheimer's amyloidogenesis with increased blood-brain barrier permeability and resistance to proteolytic degradation in plasma.

  Journal of neurobiology 1999;39(3):371-82.

• 52.

  1999

  E Matsubara; J Ghiso; B Frangione; M Amari; Y Tomidokoro; Y Ikeda; Y Harigaya; K Okamoto; M Shoji

  Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome.

  Annals of neurology 1999;45(4):537-41.

• 53.

  1998

  F Crawford; C Soto; Z Suo; C Fang; T Parker; A Sawar; B Frangione; M Mullan

  Alzheimer's beta-amyloid vasoactivity: identification of a novel beta-amyloid conformational intermediate.

  FEBS letters 1998;436(3):445-8.

• 54.

  1998

  J B Mackic; M Stins; J G McComb; M Calero; J Ghiso; K S Kim; S D Yan; D Stern; A M Schmidt; B Frangione; et al.

  Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

  The Journal of clinical investigation 1998;102(4):734-43.

• 55.

  1998

  C Soto; E M Sigurdsson; L Morelli; R A Kumar; E M Castaño; B Frangione

  Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

  Nature medicine 1998;4(7):822-6.

• 56.

  1998

  M Pappolla; P Bozner; C Soto; H Shao; N K Robakis; M Zagorski; B Frangione; J Ghiso

  Inhibition of Alzheimer beta-fibrillogenesis by melatonin.

  The Journal of biological chemistry 1998;273(13):7185-8.

• 57.

  1998

  T Wisniewski; W K Dowjat; J D Buxbaum; O Khorkova; S Efthimiopoulos; J Kulczycki; W Lojkowska; J Wegiel; H M Wisniewski; B Frangione

  A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years.

  Neuroreport 1998;9(2):217-21.

• 58.

  1998

  J B Mackic; M H Weiss; W Miao; E Kirkman; J Ghiso; M Calero; J Bading; B Frangione; B V Zlokovic

  Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy.

  Journal of neurochemistry 1998;70(1):210-5.

• 59.

  1997

  B Permanne; C Perez; C Soto; B Frangione; T Wisniewski

  Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants.

  Biochemical and biophysical research communications 1997;240(3):715-20.

• 60.

  1997

  T Wisniewski; W K Dowjat; B Permanne; J Palha; A Kumar; G Gallo; B Frangione

  Presenilin-1 is associated with Alzheimer's disease amyloid.

  The American journal of pathology 1997;151(2):601-10.

• 61.

  1997

  J Ghiso; M Calero; E Matsubara; S Governale; J Chuba; R Beavis; T Wisniewski; B Frangione

  Alzheimer's soluble amyloid beta is a normal component of human urine.

  FEBS letters 1997;408(1):105-8.

• 62.

  1996

  M Lalowski; A Golabek; C A Lemere; D J Selkoe; H M Wisniewski; R C Beavis; B Frangione; T Wisniewski

  The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid.

  The Journal of biological chemistry 1996;271(52):33623-31.

• 63.

  1996

  E M Castaño; F Prelli; C Soto; R Beavis; E Matsubara; M Shoji; B Frangione

  The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease.

  The Journal of biological chemistry 1996;271(50):32185-91.

• 64.

  1996

  C Soto; M S Kindy; M Baumann; B Frangione

  Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation.

  Biochemical and biophysical research communications 1996;226(3):672-80.

• 65.

  1996

  R Vidal; J Ghiso; T Wisniewski; B Frangione

  Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant.

  FEBS letters 1996;393(1):19-23.

• 66.

  1996

  J F Ghersi-Egea; P D Gorevic; J Ghiso; B Frangione; C S Patlak; J D Fenstermacher

  Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries.

  Journal of neurochemistry 1996;67(2):880-3.

• 67.

  1996

  F Perini; R Vidal; B Ghetti; F Tagliavini; B Frangione; F Prelli

  PrP27-30 is a normal soluble prion protein fragment released by human platelets.

  Biochemical and biophysical research communications 1996;223(3):572-7.

• 68.

  1996

  F Perini; B Frangione; F Prelli

  Prion protein released by platelets.

  Lancet 1996;347(9015):1635-6.

• 69.

  1996

  E Matsubara; C Soto; S Governale; B Frangione; J Ghiso

  Apolipoprotein J and Alzheimer's amyloid beta solubility.

  The Biochemical journal 1996;316 ( Pt 2)():671-9.

• 70.

  1996

  R Vidal; F Garzuly; H Budka; M Lalowski; R P Linke; F Brittig; B Frangione; T Wisniewski

  Meningocerebrovascular amyloidosis associated with a novel transthyretin mis-sense mutation at codon 18 (TTRD 18G)

  The American journal of pathology 1996;148(2):361-6.

• 71.

  1996

  T Wisniewski; M Lalowski; M Baumann; H Rauvala; E Raulo; R Nolo; B Frangione

  HB-GAM is a cytokine present in Alzheimer's and Down's syndrome lesions.

  Neuroreport 1996;7(2):667-71.

• 72.

  1996

  L Morelli; L Wei; A Amorim; J McDermid; C R Abee; B Frangione; L C Walker; E Levy

  Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype.

  FEBS letters 1996;379(2):132-4.

• 73.

  1996

  T Wisniewski; M Lalowski; M Bobik; M Russell; J Strosznajder; B Frangione

  Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs.

  The Biochemical journal 1996;313 ( Pt 2)():575-80.

• 74.

  1996

  T Wisniewski; B Frangione

  Molecular biology of brain aging and neurodegenerative disorders.

  Acta neurobiologiae experimentalis 1996;56(1):267-79.

• 75.

  1995

  C Soto; E M Castaño; R A Kumar; R C Beavis; B Frangione

  Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure.

  Neuroscience letters 1995;200(2):105-8.

• 76.

  1995

  E M Castaño; B Frangione

  Non-Alzheimer's disease amyloidoses of the nervous system.

  Current opinion in neurology 1995;8(4):279-85.

• 77.

  1995

  T Wisniewski; A A Golabek; E Kida; K E Wisniewski; B Frangione

  Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis.

  The American journal of pathology 1995;147(2):238-44.

• 78.

  1995

  E M Castaño; F Prelli; M Pras; B Frangione

  Apolipoprotein E carboxyl-terminal fragments are complexed to amyloids A and L. Implications for amyloidogenesis and Alzheimer's disease.

  The Journal of biological chemistry 1995;270(29):17610-5.

• 79.

  1995

  T Wisniewski; M Lalowski; A Golabek; T Vogel; B Frangione

  Is Alzheimer's disease an apolipoprotein E amyloidosis?

  Lancet 1995;345(8955):956-8.

• 80.

  1995

  M A Smith; S L Siedlak; P L Richey; P Mulvihill; J Ghiso; B Frangione; F Tagliavini; G Giaccone; O Bugiani; D Praprotnik

  Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease.

  Nature medicine 1995;1(4):365-9.

• 81.

  1995

  E Matsubara; B Frangione; J Ghiso

  Characterization of apolipoprotein J-Alzheimer's A beta interaction.

  The Journal of biological chemistry 1995;270(13):7563-7.

• 82.

  1995

  E M Castano; F Prelli; T Wisniewski; A Golabek; R A Kumar; C Soto; B Frangione

  Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

  The Biochemical journal 1995;306 ( Pt 2)():599-604.

• 83.

  1995

  C Soto; B Frangione

  Two conformational states of amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease.

  Neuroscience letters 1995;186(2-3):115-8.

• 84.

  1995

  C Soto; E M Castaño; B Frangione; N C Inestrosa

  The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation.

  The Journal of biological chemistry 1995;270(7):3063-7.

• 85.

  1995

  C A Mangone; E M Castaño; E Levy; G Abiusi; T Wisniewski; M R Marques; E Faccio; P B Gorelick; B Frangione; R E Sica

  Early onset Alzheimer's disease in a South American pedigree from Argentina.

  Acta neurologica Scandinavica 1995;91(1):6-13.

• 86.

  1994

  A Koudinov; E Matsubara; B Frangione; J Ghiso

  The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma.

  Biochemical and biophysical research communications 1994;205(2):1164-71.

• 87.

  1994

  S Gandy; G Caporaso; J Buxbaum; B Frangione; P Greengard

  APP processing, A beta-amyloidogenesis, and the pathogenesis of Alzheimer's disease.

  Neurobiology of aging 1994;15(2):253-6.

• 88.

  1993

  J E Gardella; G A Gorgone; L Candela; J Ghiso; E M Castaño; B Frangione; P D Gorevic

  High-level expression and in vitro mutagenesis of a fibrillogenic 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein.

  The Biochemical journal 1993;294 ( Pt 3)():667-74.

• 89.

  1993

  J Ghiso; E Matsubara; A Koudinov; N H Choi-Miura; M Tomita; T Wisniewski; B Frangione

  The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.

  The Biochemical journal 1993;293 ( Pt 1)():27-30.

• 90.

  1993

  F Tagliavini; G Giaccone; O Bugiani; B Frangione

  Ubiquitinated neurites are associated with preamyloid and cerebral amyloid beta deposits in patients with hereditary cerebral hemorrhage with amyloidosis Dutch type.

  Acta neuropathologica 1993;85(3):267-71.

• 91.

  1992

  J Ghiso; A Rostagno; J E Gardella; L Liem; P D Gorevic; B Frangione

  A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion.

  The Biochemical journal 1992;288 ( Pt 3)():1053-9.

• 92.

  1992

  M Shoji; T E Golde; J Ghiso; T T Cheung; S Estus; L M Shaffer; X D Cai; D M McKay; R Tintner; B Frangione

  Production of the Alzheimer amyloid beta protein by normal proteolytic processing.

  Science (New York, N.Y.) 1992;258(5079):126-9.

• 93.

  1992

  J E Gardella; G A Gorgone; P C Munoz; J Ghiso; B Frangione; P D Gorevic

  Beta protein precursor expression in human platelets and a megakaryocyte cell line. Possible implications for the origin of cerebral amyloidosis in Alzheimer's disease.

  Laboratory investigation; a journal of technical methods and pathology 1992;67(3):303-13.

• 94.

  1992

  J E Gardella; G A Gorgone; P Newman; B Frangione; P D Gorevic

  Characterization of Alzheimer amyloid precursor protein transcripts in platelets and megakarocytes.

  Neuroscience letters 1992;138(2):229-32.

• 95.

  1992

  J Ghiso; T Wisniewski; R Vidal; A Rostagno; B Frangione

  Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease.

  The Biochemical journal 1992;282 ( Pt 2)():517-22.

• 96.

  1992

  M Haltia; E Levy; J Meretoja; I Fernandez-Madrid; O Koivunen; B Frangione

  Gelsolin gene mutation--at codon 187--in familial amyloidosis, Finnish: DNA-diagnostic assay.

  American journal of medical genetics 1992;42(3):357-9.

• 97.

  1992

  F Tagliavini; G Giaccone; L Verga; B Frangione; O Bugiani

  Down syndrome as a key to the time sequence of brain changes in Alzheimer disease.

  Progress in clinical and biological research 1992;379():143-58.

• 98.

  1991

  I Fernandez-Madrid; E Levy; K Marder; B Frangione

  Codon 618 variant of Alzheimer amyloid gene associated with inherited cerebral hemorrhage.

  Annals of neurology 1991;30(5):730-3.

• 99.

  1991

  E M Castaño; T Wisniewski; B Frangione

  Inherited amyloids of the nervous system.

  Current opinion in neurobiology 1991;1(3):448-54.

• 100.

  1991

  T Wisniewski; J Ghiso; B Frangione

  Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.

  Biochemical and biophysical research communications 1991;179(3):1247-54.

• 101.

  1991

  K H el Hachimi; L Verga; G Giaccone; F Tagliavini; B Frangione; O Bugiani; J F Foncin

  Relationship between non-fibrillary amyloid precursors and cell processes in the cortical neuropil of Alzheimer patients.

  Neuroscience letters 1991;129(1):119-22.

• 102.

  1991

  F Tagliavini; G Giaccone; L Verga; J Ghiso; B Frangione; O Bugiani

  Alzheimer patients: preamyloid deposits are immunoreactive with antibodies to extracellular domains of the amyloid precursor protein.

  Neuroscience letters 1991;128(1):117-20.

• 103.

  1991

  M Haltia; J Ghiso; T Wisniewski; S Kiuru; D Miller; B Frangione

  Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies.

  Neurobiology of aging 1991;12(4):313-6.

• 104.

  1991

  E M Castaño; B Frangione

  Alzheimer's disease from the perspective of the systemic and localized forms of amyloidosis.

  Brain pathology (Zurich, Switzerland) 1991;1(4):263-71.

• 105.

  1991

  T Wisniewski; M Haltia; J Ghiso; B Frangione

  Lewy bodies are immunoreactive with antibodies raised to gelsolin related amyloid-Finnish type.

  The American journal of pathology 1991;138(5):1077-83.

• 106.

  1991

  F Tagliavini; F Prelli; J Ghiso; O Bugiani; D Serban; S B Prusiner; M R Farlow; B Ghetti; B Frangione

  Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.

  The EMBO journal 1991;10(3):513-9.

• 107.

  1990

  J Ghiso; M Haltia; F Prelli; J Novello; B Frangione

  Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type.

  The Biochemical journal 1990;272(3):827-30.

• 108.

  1990

  E Levy; M Haltia; I Fernandez-Madrid; O Koivunen; J Ghiso; F Prelli; B Frangione

  Mutation in gelsolin gene in Finnish hereditary amyloidosis.

  The Journal of experimental medicine 1990;172(6):1865-7.

• 109.

  1990

  O Bugiani; G Giaccone; L Verga; B Pollo; B Ghetti; B Frangione; F Tagliavini

  Alzheimer patients and Down patients: abnormal presynaptic terminals are related to cerebral preamyloid deposits.

  Neuroscience letters 1990;119(1):56-9.

• 110.

  1990

  G Giaccone; F Tagliavini; L Verga; B Frangione; M R Farlow; O Bugiani; B Ghetti

  Neurofibrillary tangles of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease share antigenic determinants with those of Alzheimer disease.

  Brain research 1990;530(2):325-9.

• 111.

  1990

  W F Timmers; F Tagliavini; J Haan; B Frangione

  Parenchymal preamyloid and amyloid deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis--Dutch type.

  Neuroscience letters 1990;118(2):223-6.

• 112.

  1990

  F Prelli; E Levy; S G van Duinen; G T Bots; W Luyendijk; B Frangione

  Expression of a normal and variant Alzheimer's beta-protein gene in amyloid of hereditary cerebral hemorrhage, Dutch type: DNA and protein diagnostic assays.

  Biochemical and biophysical research communications 1990;170(1):301-7.

• 113.

  1990

  G Giaccone; L Verga; M Finazzi; B Pollo; F Tagliavini; B Frangione; O Bugiani

  Cerebral preamyloid deposits and congophilic angiopathy in aged dogs.

  Neuroscience letters 1990;114(2):178-83.

• 114.

  1990

  E Levy; M D Carman; I J Fernandez-Madrid; M D Power; I Lieberburg; S G van Duinen; G T Bots; W Luyendijk; B Frangione

  Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

  Science (New York, N.Y.) 1990;248(4959):1124-6.

• 115.

  1990

  F Tagliavini; J Ghiso; W F Timmers; G Giaccone; O Bugiani; B Frangione

  Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls.

  Laboratory investigation; a journal of technical methods and pathology 1990;62(6):761-7.

• 116.

  1990

  M Haltia; J Ghiso; F Prelli; G Gallo; S Kiuru; H Somer; J Palo; B Frangione

  Amyloid in familial amyloidosis, Finnish type, is antigenically and structurally related to gelsolin.

  The American journal of pathology 1990;136(6):1223-8.

• 117.

  1990

  M Haltia; F Prelli; J Ghiso; S Kiuru; H Somer; J Palo; B Frangione

  Amyloid protein in familial amyloidosis (Finnish type) is homologous to gelsolin, an actin-binding protein.

  Biochemical and biophysical research communications 1990;167(3):927-32.

• 118.

  1990

  M M Picken; M Larrondo-Lillo; F Coria; G R Gallo; M L Shelanski; B Frangione

  Distribution of the protease inhibitor alpha 1-antichymotrypsin in cerebral and systemic amyloid.

  Journal of neuropathology and experimental neurology 1990;49(1):41-8.

• 119.

  1989

  L Verga; B Frangione; F Tagliavini; G Giaccone; A Migheli; O Bugiani

  Alzheimer patients and Down patients: cerebral preamyloid deposits differ ultrastructurally and histochemically from the amyloid of senile plaques.

  Neuroscience letters 1989;105(3):294-9.

• 120.

  1989

  O Bugiani; G Giaccone; B Frangione; B Ghetti; F Tagliavini

  Alzheimer patients: preamyloid deposits are more widely distributed than senile plaques throughout the central nervous system.

  Neuroscience letters 1989;103(3):263-8.

• 121.

  1989

  J Ghiso; F Tagliavini; W F Timmers; B Frangione

  Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization.

  Biochemical and biophysical research communications 1989;163(1):430-7.

• 122.

  1989

  E Levy; C Lopez-Otin; J Ghiso; D Geltner; B Frangione

  Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases.

  The Journal of experimental medicine 1989;169(5):1771-8.

• 123.

  1989

  P D Gorevic; F C Prelli; J Wright; M Pras; B Frangione

  Systemic senile amyloidosis. Identification of a new prealbumin (transthyretin) variant in cardiac tissue: immunologic and biochemical similarity to one form of familial amyloidotic polyneuropathy.

  The Journal of clinical investigation 1989;83(3):836-43.

• 124.

  1989

  G Giaccone; F Tagliavini; G Linoli; C Bouras; L Frigerio; B Frangione; O Bugiani

  Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques.

  Neuroscience letters 1989;97(1-2):232-8.

• 125.

  1989

  F Tagliavini; G Giaccone; G Linoli; B Frangione; O Bugiani

  Cerebral extracellular preamyloid deposits in Alzheimer's disease, Down syndrome and nondemented elderly individuals.

  Progress in clinical and biological research 1989;317():1001-5.

• 126.

  1989

  B Frangione

  Systemic and cerebral amyloidosis.

  Annals of medicine 1989;21(2):69-72.

• 127.

  1988

  F Tagliavini; G Giaccone; B Frangione; O Bugiani

  Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals.

  Neuroscience letters 1988;93(2-3):191-6.

• 128.

  1988

  F Coria; F Prelli; E M Castaño; M Larrondo-Lillo; J Fernandez-Gonzalez; S G van Duinen; G T Bots; W Luyendijk; M L Shelanski; B Frangione

  Beta-protein deposition: a pathogenetic link between Alzheimer's disease and cerebral amyloid angiopathies.

  Brain research 1988;463(1):187-91.

• 129.

  1988

  F Prelli; E Castaño; G G Glenner; B Frangione

  Differences between vascular and plaque core amyloid in Alzheimer's disease.

  Journal of neurochemistry 1988;51(2):648-51.

• 130.

  1988

  J Ghiso; N Cowan; B Frangione

  Isolation of a sequence encoding human cystatin C. Conservation of exon-intron structure between members of the cysteine proteinase inhibitors superfamily.

  Biological chemistry Hoppe-Seyler 1988;369 Suppl():205-8.

• 131.

  1988

  F Coria; E Castaño; F Prelli; M Larrondo-Lillo; S van Duinen; M L Shelanski; B Frangione

  Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis.

  Laboratory investigation; a journal of technical methods and pathology 1988;58(4):454-8.

• 132.

  1988

  F Prelli; E M Castaño; S G van Duinen; G T Bots; W Luyendijk; B Frangione

  Different processing of Alzheimer's beta-protein precursor in the vessel wall of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type.

  Biochemical and biophysical research communications 1988;151(3):1150-5.

• 133.

  1988

  E M Castaño; B Frangione

  Human amyloidosis, Alzheimer disease and related disorders.

  Laboratory investigation; a journal of technical methods and pathology 1988;58(2):122-32.

• 134.

  1987

  F Prelli; M Pras; B Frangione

  Degradation and deposition of amyloid AA fibrils are tissue specific.

  Biochemistry 1987;26(25):8251-6.

• 135.

  1987

  A H Warfel; D Zucker-Franklin; B Frangione; J Ghiso

  Constitutive secretion of cystatin C (gamma-trace) by monocytes and macrophages and its downregulation after stimulation.

  The Journal of experimental medicine 1987;166(6):1912-7.

• 136.

  1987

  F Coria; E M Castaño; B Frangione

  Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer's disease beta-protein.

  The American journal of pathology 1987;129(3):422-8.

• 137.

  1987

  P D Gorevic; E M Castano; R Sarma; B Frangione

  Ten to fourteen residue peptides of Alzheimer's disease protein are sufficient for amyloid fibril formation and its characteristic x-ray diffraction pattern.

  Biochemical and biophysical research communications 1987;147(2):854-62.

• 138.

  1987

  S G van Duinen; E M Castaño; F Prelli; G T Bots; W Luyendijk; B Frangione

  Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease.

  Proceedings of the National Academy of Sciences of the United States of America 1987;84(16):5991-4.

• 139.

  1986

  P D Gorevic; F Goñi; B Pons-Estel; F Alvarez; N S Peress; B Frangione

  Isolation and partial characterization of neurofibrillary tangles and amyloid plaque core in Alzheimer's disease: immunohistological studies.

  Journal of neuropathology and experimental neurology 1986;45(6):647-64.

• 140.

  1986

  J Ghiso; O Jensson; B Frangione

  Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C).

  Proceedings of the National Academy of Sciences of the United States of America 1986;83(9):2974-8.

• 141.

  1986

  J Ghiso; B Pons-Estel; B Frangione

  Hereditary cerebral amyloid angiopathy: the amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases.

  Biochemical and biophysical research communications 1986;136(2):548-54.

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