Grant Detail
The grant detail shows the name of the PI, active dates of the project, the funding institute and the abstract of the grant. This abstract is what is used to create the fingerprint of the grant. If any publications referencing this grant are found in the data, they will be listed here as well.
Massachusetts Alzheimer's Disease Research Center
1 April 1997 - 31 March 2009
NATIONAL INSTITUTE ON AGING
Total Funding: $ 36,612,653
The Massachusetts Alzheimer's Disease Research Center (ADRC) is a multi-institutional consortium composed of Harvard-affiliated facilities including the Massachusetts General Hospital, the Brigham and Women's Hospital, the Harvard Division on Aging and the Hebrew Rehabilitation Center for the Aged. The broad goals of the Massachusetts ADRC have evolved from those first proposed in 1984 but remain constant in the mission to prevent, cure or at least treat effectively AD and related dementing diseases. The specific goals are: To propose and support new research in neuroscience directed toward uncovering the etiology and pathogenetic mechanisms of AD and related dementias; to enhance collaborative dementia research funded outside of the ADRC; and to catalyze education, training and information transfer related to AD and related dementias. To accomplish these goals, we will retain the four Core facilities that were established 20 years ago. Investigators in the Clinical Core examine and diagnose patients with AD and related disorders, and refer them for participation in specific research Projects. The purpose of the Neuropathology Core is to establish diagnoses on all brains submitted to the Tissue Resource Center, store fixed and frozen brain tissue and distribute brain tissue to qualified investigators. The Education and Information Transfer Core has developed programs to train future leaders in academic fields related to aging and dementia, to educate caregivers, and to enroll elderly, non-demented control subjects into ADRC research. To these four Cores, we have added a fifth: The Data Management and Statistics Core that will carry on and expand activities that had previously been housed in the Administrative Core. The overriding mission of the ADRC is to stimulate and support research of the highest quality. This application contains three R01-type Projects that are closely inter-related and also tightly linked to the Clinical, Neuropathological and Data Management and Statistics Cores.
293 Resulting Publications
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1.
2013Katherine J Kopeikina; Manuela Polydoro; Hwan-Ching Tai; Erich Yaeger; George A Carlson; Rose Pitstick; Bradley T Hyman; Tara L Spires-Jones
Synaptic alterations in the rTg4510 mouse model of tauopathy.
The Journal of comparative neurology 2013;521(6):1334-53. -
2.
2013Shaomin Li; Ming Jin; Dainan Zhang; Ting Yang; Thomas Koeglsperger; Hongjun Fu; Dennis J Selkoe
Neuron 2013;77(5):929-41. -
3.
2013Anke Wahler; Anja-Silke Beyer; Ilona E Keller; Cathrin Schnack; Björn von Einem; Christian Pröpper; Tobias M Boeckers; Ithan D Peltan; Dudley K Strickland; Bradley T Hyman; et al.
The Biochemical journal 2013;450(2):333-43. -
4.
2013Patrick Holton; Mina Ryten; Michael Nalls; Daniah Trabzuni; Michael E Weale; Dena Hernandez; Helen Crehan; J Raphael Gibbs; Richard Mayeux; Jonathan L Haines; et al.
Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.
Annals of human genetics 2013;77(2):85-105. -
5.
2012Tadafumi Hashimoto; Alberto Serrano-Pozo; Yukiko Hori; Kenneth W Adams; Shuko Takeda; Adrian Olaf Banerji; Akinori Mitani; Daniel Joyner; Diana H Thyssen; Brian J Bacskai; et al.
Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(43):15181-92. -
6.
2012Gyungah Jun; Badri N Vardarajan; Jacqueline Buros; Chang-En Yu; Michele V Hawk; Beth A Dombroski; Paul K Crane; Eric B Larson; ; Richard Mayeux; et al.
Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.
Archives of neurology 2012;69(10):1270-9. -
7.
2012Nikita Rudinskiy; Jonathan M Hawkes; Rebecca A Betensky; Megumi Eguchi; Shun Yamaguchi; Tara L Spires-Jones; Bradley T Hyman
Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease.
Nature neuroscience 2012;15(10):1422-9. -
8.
2012Gillian Hamilton; Richard Killick; ; ; Jean-Charles Lambert; Philippe Amouyel; ; Minerva M Carrasquillo; V Shane Pankratz; Neill R Graff-Radford; et al.
Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.
Neurobiology of aging 2012;33(8):1848.e1-13. -
9.
2012Alberto Serrano-Pozo; Matthew L Mielke; Alona Muzitansky; Teresa Gómez-Isla; John H Growdon; Brian J Bacskai; Rebecca A Betensky; Matthew P Frosch; Bradley T Hyman
Stable size distribution of amyloid plaques over the course of Alzheimer disease.
Journal of neuropathology and experimental neurology 2012;71(8):694-701. -
10.
2012Olivia I Okereke; Norberto Pantoja-Galicia; Maura Copeland; Bradley T Hyman; Taylor Wanggaard; Marilyn S Albert; Rebecca A Betensky; Deborah Blacker
The SIST-M: predictive validity of a brief structured clinical dementia rating interview.
Alzheimer disease and associated disorders 2012;26(3):225-31. -
11.
2012Robert M Koffie; Tadafumi Hashimoto; Hwan-Ching Tai; Kevin R Kay; Alberto Serrano-Pozo; Daniel Joyner; Steven Hou; Katherine J Kopeikina; Matthew P Frosch; Virginia M Lee; et al.
Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.
Brain : a journal of neurology 2012;135(Pt 7):2155-68. -
12.
2012Stephen N Gomperts; Joseph J Locascio; Marta Marquie; Andrea L Santarlasci; Dorene M Rentz; Jacqueline Maye; Keith A Johnson; John H Growdon
Brain amyloid and cognition in Lewy body diseases.
Movement disorders : official journal of the Movement Disorder Society 2012;27(8):965-73. -
13.
2012Michael T Lin; Ippolita Cantuti-Castelvetri; Kangni Zheng; Katie E Jackson; Yong B Tan; Thomas Arzberger; Andrew J Lees; Rebecca A Betensky; M Flint Beal; David K Simon
Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease.
Annals of neurology 2012;71(6):850-4. -
14.
2012S Barral; T Bird; A Goate; M R Farlow; R Diaz-Arrastia; D A Bennett; N Graff-Radford; B F Boeve; R A Sweet; Y Stern; et al.
Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.
Neurology 2012;78(19):1464-71. -
15.
2012Anja-Silke Beyer; Bjoern von Einem; Daniel Schwanzar; Ilona E Keller; Anke Hellrung; Dietmar R Thal; Martin Ingelsson; Alexandra Makarova; Meihua Deng; Ekta S Chhabra; et al.
Neurobiology of aging 2012;33(4):732-43. -
16.
2012B DaRocha-Souto; M Coma; B G Pérez-Nievas; T C Scotton; M Siao; P Sánchez-Ferrer; T Hashimoto; Z Fan; E Hudry; I Barroeta; et al.
Neurobiology of disease 2012;45(1):425-37. -
17.
2012Bradley T Hyman; Creighton H Phelps; Thomas G Beach; Eileen H Bigio; Nigel J Cairns; Maria C Carrillo; Dennis W Dickson; Charles Duyckaerts; Matthew P Frosch; Eliezer Masliah; et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012;8(1):1-13. -
18.
2012Fanggeng Zou; High Seng Chai; Curtis S Younkin; Mariet Allen; Julia Crook; V Shane Pankratz; Minerva M Carrasquillo; Christopher N Rowley; Asha A Nair; Sumit Middha; et al.
Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.
PLoS genetics 2012;8(6):e1002707. -
19.
2012Luxiang Cao; Benjamin R Schrank; Steve Rodriguez; Eric G Benz; Thomas W Moulia; Gregory T Rickenbacher; Alexis C Gomez; Yona Levites; Sarah R Edwards; Todd E Golde; et al.
Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo.
Nature communications 2012;3():1009. -
20.
2012Juan Qu; Roland Matsouaka; Rebecca A Betensky; Bradley T Hyman; Cynthia L Grosskreutz
Calcineurin activation causes retinal ganglion cell degeneration.
Molecular vision 2012;18():2828-38. -
21.
2011Robert M Koffie; Christian T Farrar; Laiq-Jan Saidi; Christopher M William; Bradley T Hyman; Tara L Spires-Jones
Proceedings of the National Academy of Sciences of the United States of America 2011;108(46):18837-42. -
22.
2011Stéphane P Poulin; Rebecca Dautoff; John C Morris; Lisa Feldman Barrett; Bradford C Dickerson;
Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity.
Psychiatry research 2011;194(1):7-13. -
23.
2011Katherine J Kopeikina; George A Carlson; Rose Pitstick; Adam E Ludvigson; Alan Peters; Jennifer I Luebke; Robert M Koffie; Matthew P Frosch; Bradley T Hyman; Tara L Spires-Jones
The American journal of pathology 2011;179(4):2071-82. -
24.
2011Alberto Serrano-Pozo; Matthew L Mielke; Teresa Gómez-Isla; Rebecca A Betensky; John H Growdon; Matthew P Frosch; Bradley T Hyman
Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease.
The American journal of pathology 2011;179(3):1373-84. -
25.
2011Bradley T Hyman
Amyloid-dependent and amyloid-independent stages of Alzheimer disease.
Archives of neurology 2011;68(8):1062-4. -
26.
2011Reisa A Sperling; Clifford R Jack; Sandra E Black; Matthew P Frosch; Steven M Greenberg; Bradley T Hyman; Philip Scheltens; Maria C Carrillo; William Thies; Martin M Bednar; et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(4):367-85. -
27.
2011Niklas Mattsson; Ulf Andreasson; Staffan Persson; Hiroyuki Arai; Sat Dev Batish; Sergio Bernardini; Luisella Bocchio-Chiavetto; Marinus A Blankenstein; Maria C Carrillo; Sonia Chalbot; et al.
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(4):386-395.e6. -
28.
2011Gregory Crosby; Deborah J Culley; Bradley T Hyman
Preoperative cognitive assessment of the elderly surgical patient: a call for action.
Anesthesiology 2011;114(6):1265-8. -
29.
2011Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; et al.
Nature genetics 2011;43(5):436-41. -
30.
2011Reisa A Sperling; Paul S Aisen; Laurel A Beckett; David A Bennett; Suzanne Craft; Anne M Fagan; Takeshi Iwatsubo; Clifford R Jack; Jeffrey Kaye; Thomas J Montine; et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(3):280-92. -
31.
2011B C Dickerson; T R Stoub; R C Shah; R A Sperling; R J Killiany; M S Albert; B T Hyman; D Blacker; L Detoledo-Morrell
Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults.
Neurology 2011;76(16):1395-402. -
32.
2011Lena Skoglund; Toshifumi Matsui; Stefanie H Freeman; Anders Wallin; Elin S Blom; Matthew P Frosch; John H Growdon; Bradley T Hyman; Lars Lannfelt; Martin Ingelsson; et al.
Novel progranulin mutation detected in 2 patients with FTLD.
Alzheimer disease and associated disorders 2011;25(2):173-8. -
33.
2011Alice S Chen-Plotkin; Maria Martinez-Lage; Patrick M A Sleiman; William Hu; Robert Greene; Elisabeth McCarty Wood; Shaoxu Bing; Murray Grossman; Gerard D Schellenberg; Kimmo J Hatanpaa; et al.
Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.
Archives of neurology 2011;68(4):488-97. -
34.
2011Anete Rozkalne; Bradley T Hyman; Tara L Spires-Jones
Neurobiology of disease 2011;41(3):650-4. -
35.
2011Olivia I Okereke; Maura Copeland; Bradley T Hyman; Taylor Wanggaard; Marilyn S Albert; Deborah Blacker
Archives of neurology 2011;68(3):343-50. -
36.
2011Ellen M Wijsman; Nathan D Pankratz; Yoonha Choi; Joseph H Rothstein; Kelley M Faber; Rong Cheng; Joseph H Lee; Thomas D Bird; David A Bennett; Ramon Diaz-Arrastia; et al.
PLoS genetics 2011;7(2):e1001308. -
37.
2011Tara L Spires-Jones; Kevin Kay; Roland Matsouka; Anete Rozkalne; Rebecca A Betensky; Bradley T Hyman
Neuroscience letters 2011;487(3):260-3. -
38.
2011Robert S Wilson; Sandra Barral; Joseph H Lee; Sue E Leurgans; Tatiana M Foroud; Robert A Sweet; Neill Graff-Radford; Thomas D Bird; Richard Mayeux; David A Bennett
Heritability of different forms of memory in the Late Onset Alzheimer's Disease Family Study.
Journal of Alzheimer's disease : JAD 2011;23(2):249-55. -
39.
2011Phillip B Jones; Kenneth W Adams; Anete Rozkalne; Tara L Spires-Jones; Tammy T Hshieh; Tadafumi Hashimoto; Christine A F von Armin; Mathew Mielke; Brian J Bacskai; Bradley T Hyman
PloS one 2011;6(1):e14586. -
40.
2010Gyungah Jun; Adam C Naj; Gary W Beecham; Li-San Wang; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Nilufer Ertekin-Taner; M Daniele Fallin; Robert Friedland; et al.
Archives of neurology 2010;67(12):1473-84. -
41.
2010Alberto Serrano-Pozo; Gloria L Vega; Dieter Lütjohann; Joseph J Locascio; Marsha K Tennis; Amy Deng; Alireza Atri; Bradley T Hyman; Michael C Irizarry; John H Growdon
Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers.
Alzheimer disease and associated disorders 2010;24(3):220-6. -
42.
2010Robert S Wilson; Sue E Leurgans; Tatiana M Foroud; Robert A Sweet; Neill Graff-Radford; Richard Mayeux; David A Bennett;
Telephone assessment of cognitive function in the late-onset Alzheimer's disease family study.
Archives of neurology 2010;67(7):855-61. -
43.
2010Jason J Corneveaux; Winnie S Liang; Eric M Reiman; Jennifer A Webster; Amanda J Myers; Victoria L Zismann; Keta D Joshipura; John V Pearson; Diane Hu-Lince; David W Craig; et al.
Evidence for an association between KIBRA and late-onset Alzheimer's disease.
Neurobiology of aging 2010;31(6):901-9. -
44.
2010M Coma; L Serenó; B Da Rocha-Souto; T C Scotton; J España; M B Sánchez; M Rodríguez; J Agulló; C Guardia-Laguarta; M Garcia-Alloza; et al.
Neurobiology of disease 2010;38(3):482-91. -
45.
2010Alberto Serrano-Pozo; Christopher M William; Isidro Ferrer; Emmanuelle Uro-Coste; Marie-Bernadette Delisle; Claude-Alain Maurage; Christoph Hock; Roger M Nitsch; Eliezer Masliah; John H Growdon; et al.
Brain : a journal of neurology 2010;133(Pt 5):1312-27. -
46.
2010Robert A Sweet; David A Bennett; Neill R Graff-Radford; Richard Mayeux;
Brain : a journal of neurology 2010;133(Pt 4):1155-62. -
47.
2010Reisa A Sperling; Bradford C Dickerson; Maija Pihlajamaki; Patrizia Vannini; Peter S LaViolette; Ottavio V Vitolo; Trey Hedden; J Alex Becker; Dorene M Rentz; Dennis J Selkoe; et al.
Functional alterations in memory networks in early Alzheimer's disease.
Neuromolecular medicine 2010;12(1):27-43. -
48.
2010Vivianna M Van Deerlin; Patrick M A Sleiman; Maria Martinez-Lage; Alice Chen-Plotkin; Li-San Wang; Neill R Graff-Radford; Dennis W Dickson; Rosa Rademakers; Bradley F Boeve; Murray Grossman; et al.
Nature genetics 2010;42(3):234-9. -
49.
2010Maija Pihlajamäki; Kelly O' Keefe; Lars Bertram; Rudolph E Tanzi; Bradford C Dickerson; Deborah Blacker; Marilyn S Albert; Reisa A Sperling
Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease.
Alzheimer disease and associated disorders 2010;24(1):28-36. -
50.
2009S Salloway; R Sperling; S Gilman; N C Fox; K Blennow; M Raskind; M Sabbagh; L S Honig; R Doody; C H van Dyck; et al.
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease.
Neurology 2009;73(24):2061-70. -
51.
2009Will Stoothoff; Phillip B Jones; Tara L Spires-Jones; Daniel Joyner; Ekta Chhabra; Kathryn Bercury; Zhanyun Fan; Hong Xie; Brian Bacskai; Jon Edd; et al.
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.
Journal of neurochemistry 2009;111(2):417-27. -
52.
2009Reisa A Sperling; Peter S Laviolette; Kelly O'Keefe; Jacqueline O'Brien; Dorene M Rentz; Maija Pihlajamaki; Gad Marshall; Bradley T Hyman; Dennis J Selkoe; Trey Hedden; et al.
Neuron 2009;63(2):178-88. -
53.
2009Alix de Calignon; Tara L Spires-Jones; Rose Pitstick; George A Carlson; Bradley T Hyman
Journal of neuropathology and experimental neurology 2009;68(7):757-61. -
54.
2009Robert M Koffie; Melanie Meyer-Luehmann; Tadafumi Hashimoto; Kenneth W Adams; Matthew L Mielke; Monica Garcia-Alloza; Kristina D Micheva; Stephen J Smith; M Leo Kim; Virginia M Lee; et al.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):4012-7. -
55.
2009Bradford C Dickerson; Akram Bakkour; David H Salat; Eric Feczko; Jenni Pacheco; Douglas N Greve; Fran Grodstein; Christopher I Wright; Deborah Blacker; H Diana Rosas; et al.
Cerebral cortex (New York, N.Y. : 1991) 2009;19(3):497-510. -
56.
2009A Viswanathan; S Raj; S M Greenberg; M Stampfer; S Campbell; B T Hyman; M C Irizarry
Neurology 2009;72(3):268-72. -
57.
2009Stefanie H Freeman; Bradley T Hyman; Katherine B Sims; E T Hedley-Whyte; Arastoo Vossough; Matthew P Frosch; Jeremy D Schmahmann
Brain pathology (Zurich, Switzerland) 2009;19(1):39-47. -
58.
2009Elin S Blom; Vilmantas Giedraitis; Henrik Zetterberg; Hiroaki Fukumoto; Kaj Blennow; Bradley T Hyman; Michael C Irizarry; Lars-Olof Wahlund; Lars Lannfelt; Martin Ingelsson
Dementia and geriatric cognitive disorders 2009;27(5):458-64. -
59.
2009Lena Skoglund; Sofie Ingvast; Toshifumi Matsui; Stefanie H Freeman; Matthew P Frosch; Rosemarie Brundin; Vilmantas Giedraitis; John H Growdon; Bradley T Hyman; Lars Lannfelt; et al.
Dementia and geriatric cognitive disorders 2009;28(5):471-5. -
60.
2008Stefanie H Freeman; Ruth Kandel; Luis Cruz; Anete Rozkalne; Kathy Newell; Matthew P Frosch; E Tessa Hedley-Whyte; Joseph J Locascio; Lewis A Lipsitz; Bradley T Hyman
Journal of neuropathology and experimental neurology 2008;67(12):1205-12. -
61.
2008William H Stoothoff; Brian J Bacskai; Bradley T Hyman
Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons.
Journal of biomedical optics 2008;13(6):064039. -
62.
2008Paul O'Callaghan; Elina Sandwall; Jin-Ping Li; Hong Yu; Rivka Ravid; Zhi-Zhong Guan; Toin H van Kuppevelt; Lars N G Nilsson; Martin Ingelsson; Bradley T Hyman; et al.
Brain pathology (Zurich, Switzerland) 2008;18(4):548-61. -
63.
2008J Sundelöf; J Arnlöv; E Ingelsson; J Sundström; S Basu; B Zethelius; A Larsson; M C Irizarry; V Giedraitis; E Rönnemaa; et al.
Serum cystatin C and the risk of Alzheimer disease in elderly men.
Neurology 2008;71(14):1072-9. -
64.
2008S N Gomperts; D M Rentz; E Moran; J A Becker; J J Locascio; W E Klunk; C A Mathis; D R Elmaleh; T Shoup; A J Fischman; et al.
Imaging amyloid deposition in Lewy body diseases.
Neurology 2008;71(12):903-10. -
65.
2008Alireza Atri; Lynn W Shaughnessy; Joseph J Locascio; John H Growdon
Long-term course and effectiveness of combination therapy in Alzheimer disease.
Alzheimer disease and associated disorders 2008;22(3):209-21. -
66.
2008Joshua R Steinerman; Michael Irizarry; Nikolaos Scarmeas; Susan Raju; Jason Brandt; Marilyn Albert; Deborah Blacker; Bradley Hyman; Yaakov Stern
Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study.
Archives of neurology 2008;65(7):906-12. -
67.
2008Joseph J Locascio; Hiroaki Fukumoto; Liang Yap; Teodoro Bottiglieri; John H Growdon; Bradley T Hyman; Michael C Irizarry
Archives of neurology 2008;65(6):776-85. -
68.
2008Johan Sundelöf; Vilmantas Giedraitis; Michael C Irizarry; Johan Sundström; Erik Ingelsson; Elina Rönnemaa; Johan Arnlöv; Malin Degerman Gunnarsson; Bradley T Hyman; Hans Basun; et al.
Archives of neurology 2008;65(2):256-63. -
69.
2008Stefanie H Freeman; Tara Spires-Jones; Bradley T Hyman; John H Growdon; Matthew P Frosch
TAR-DNA binding protein 43 in Pick disease.
Journal of neuropathology and experimental neurology 2008;67(1):62-7. -
70.
2008Francine Grodstein; Marieke van Oijen; Michael C Irizarry; H Diana Rosas; Bradley T Hyman; John H Growdon; Immaculata De Vivo
PloS one 2008;3(2):e1590. -
71.
2007Bradford C Dickerson; Reisa A Sperling; Bradley T Hyman; Marilyn S Albert; Deborah Blacker
Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment.
Archives of general psychiatry 2007;64(12):1443-50. -
72.
2007Vilmantas Giedraitis; Johan Sundelöf; Michael C Irizarry; Nina Gårevik; Bradley T Hyman; Lars-Olof Wahlund; Martin Ingelsson; Lars Lannfelt
Neuroscience letters 2007;427(3):127-31. -
73.
2007Martin Ingelsson; Karunya Ramasamy; Carsten Russ; Stefanie H Freeman; Jennifer Orne; Susan Raju; Toshifumi Matsui; John H Growdon; Matthew P Frosch; Bernardino Ghetti; et al.
Acta neuropathologica 2007;114(5):471-9. -
74.
2007Chris Conrad; Jun Zhu; Cintia Conrad; David Schoenfeld; Zhide Fang; Martin Ingelsson; Stefan Stamm; George Church; Bradley T Hyman
Single molecule profiling of tau gene expression in Alzheimer's disease.
Journal of neurochemistry 2007;103(3):1228-36. -
75.
2007Keith A Johnson; Matt Gregas; John A Becker; Catherine Kinnecom; David H Salat; Erin K Moran; Erin E Smith; Jonathan Rosand; Dorene M Rentz; William E Klunk; et al.
Imaging of amyloid burden and distribution in cerebral amyloid angiopathy.
Annals of neurology 2007;62(3):229-34. -
76.
2007Toshifumi Matsui; Martin Ingelsson; Hiroaki Fukumoto; Karunya Ramasamy; Hisatomo Kowa; Matthew P Frosch; Michael C Irizarry; Bradley T Hyman
Expression of APP pathway mRNAs and proteins in Alzheimer's disease.
Brain research 2007;1161():116-23. -
77.
2007Eric M Reiman; Jennifer A Webster; Amanda J Myers; John Hardy; Travis Dunckley; Victoria L Zismann; Keta D Joshipura; John V Pearson; Diane Hu-Lince; Matthew J Huentelman; et al.
GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.
Neuron 2007;54(5):713-20. -
78.
2007Michelle L Steinhilb; Dora Dias-Santagata; Erin E Mulkearns; Joshua M Shulman; Jacek Biernat; Eva-Maria Mandelkow; Mel B Feany
S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.
Journal of neuroscience research 2007;85(6):1271-8. -
79.
2007Stefanie H Freeman; Susan Raju; Bradley T Hyman; Matthew P Frosch; Michael C Irizarry
Plasma Abeta levels do not reflect brain Abeta levels.
Journal of neuropathology and experimental neurology 2007;66(4):264-71. -
80.
2007Brian J Bacskai; Matthew P Frosch; Stefanie H Freeman; Scott B Raymond; Jean C Augustinack; Keith A Johnson; Michael C Irizarry; William E Klunk; Chester A Mathis; Steven T Dekosky; et al.
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.
Archives of neurology 2007;64(3):431-4. -
81.
2007Tudor A Fulga; Ilan Elson-Schwab; Vikram Khurana; Michelle L Steinhilb; Tara L Spires; Bradley T Hyman; Mel B Feany
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
Nature cell biology 2007;9(2):139-48. -
82.
2007M C Irizarry; Y Yao; B T Hyman; J H Growdon; D Praticò
Plasma F2A isoprostane levels in Alzheimer's and Parkinson's disease.
Neuro-degenerative diseases 2007;4(6):403-5. -
83.
2006Zhongcong Xie; Yuanlin Dong; Uta Maeda; Robert Moir; Sharon K Inouye; Deborah J Culley; Gregory Crosby; Rudolph E Tanzi
Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(12):1300-6. -
84.
2006Kim A Celone; Vince D Calhoun; Bradford C Dickerson; Alireza Atri; Elizabeth F Chua; Saul L Miller; Kristina DePeau; Doreen M Rentz; Dennis J Selkoe; Deborah Blacker; et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(40):10222-31. -
85.
2006Martin Ingelsson; Karunya Ramasamy; Ippolita Cantuti-Castelvetri; Lena Skoglund; Toshifumi Matsui; Jennifer Orne; Hasimoto Kowa; Susan Raju; Charles R Vanderburg; Jean C Augustinack; et al.
Acta neuropathologica 2006;112(4):439-49. -
86.
2006Toshifumi Matsui; Karunya Ramasamy; Martin Ingelsson; Hiroaki Fukumoto; Cintia Conrad; Matthew P Frosch; Michael C Irizarry; Junying Yuan; Bradley T Hyman
Journal of neuropathology and experimental neurology 2006;65(5):508-15. -
87.
2006Matthew Townsend; Ganesh M Shankar; Tapan Mehta; Dominic M Walsh; Dennis J Selkoe
The Journal of physiology 2006;572(Pt 2):477-92. -
88.
2006J Klucken; M Ingelsson; Y Shin; M C Irizarry; E T Hedley-Whyte; M Frosch; J Growdon; Pamela McLean; Bradley T Hyman
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.
Acta neuropathologica 2006;111(2):101-8. -
89.
2006M E Gurol; M C Irizarry; E E Smith; S Raju; R Diaz-Arrastia; T Bottiglieri; J Rosand; J H Growdon; S M Greenberg
Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy.
Neurology 2006;66(1):23-9. -
90.
2005Ippolita Cantuti-Castelvetri; Jochen Klucken; Martin Ingelsson; Karunya Ramasamy; Pamela J McLean; Matthew P Frosch; Bradley T Hyman; David G Standaert
Alpha-synuclein and chaperones in dementia with Lewy bodies.
Journal of neuropathology and experimental neurology 2005;64(12):1058-66. -
91.
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2003Martin Ingelsson; Youngah Shin; Michael C Irizarry; Bradley T Hyman; Lena Lilius; Charlotte Forsell; Caroline Graff
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Annals of neurology 1997;41(1):17-24. -
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Neurobiology of aging 1994;15 Suppl 2():S171-4. -
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1994B T Hyman
Studying the Alzheimer's disease brain: insights, puzzles, and opportunities.
Neurobiology of aging 1994;15 Suppl 2():S79-83. -
217.
1993A C Bowling; J B Schulz; R H Brown; M F Beal
Journal of neurochemistry 1993;61(6):2322-5. -
218.
1993R M Nitsch; J K Blusztajn; F M Doyle; Y Robitaille; R J Wurtman; J H Growdon; S J Kish
Neuroscience letters 1993;161(2):191-4. -
219.
1993P Mecocci; U MacGarvey; A E Kaufman; D Koontz; J M Shoffner; D C Wallace; M F Beal
Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.
Annals of neurology 1993;34(4):609-16. -
220.
1993A C Bowling; E M Mutisya; L C Walker; D L Price; L C Cork; M F Beal
Age-dependent impairment of mitochondrial function in primate brain.
Journal of neurochemistry 1993;60(5):1964-7. -
221.
1993M F Beal; B T Hyman; W Koroshetz
Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
Trends in neurosciences 1993;16(4):125-31. -
222.
1993U Kischka; A S Mandir; J Ghika; J H Growdon
Electrophysiologic detection of extrapyramidal motor signs in Alzheimer's disease.
Neurology 1993;43(3 Pt 1):500-5. -
223.
1993M A Pericak-Vance; P H St George-Hyslop; P C Gaskell; J Growdon; B J Crain; C Hulette; J F Gusella; L Yamaoka; R E Tanzi; A D Roses
Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets.
Genetic epidemiology 1993;10(6):361-4. -
224.
1993W Du; C DiLuca; J H Growdon
Weight loss in Alzheimer's disease.
Journal of geriatric psychiatry and neurology 1993;6(1):34-8. -
225.
1992P E Fraser; J T Nguyen; D T Chin; D A Kirschner
Journal of neurochemistry 1992;59(4):1531-40. -
226.
1992A Cronin-Golomb; M M Keane; A Kokodis; S Corkin; J H Growdon
Category knowledge in Alzheimer's disease: normal organization and a general retrieval deficit.
Psychology and aging 1992;7(3):359-66. -
227.
1992N W Kowall; A C McKee; B A Yankner; M F Beal
In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment.
Neurobiology of aging 1992;13(5):537-42. -
228.
1992K A Johnson; R A Sperling; B L Holman; J S Nagel; J H Growdon
Cerebral perfusion in progressive supranuclear palsy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(5):704-9. -
229.
1992R M Nitsch; J K Blusztajn; A G Pittas; B E Slack; J H Growdon; R J Wurtman
Evidence for a membrane defect in Alzheimer disease brain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(5):1671-5. -
230.
1992P V Arriagada; J H Growdon; E T Hedley-Whyte; B T Hyman
Neurology 1992;42(3 Pt 1):631-9. -
231.
1992B T Hyman; R E Tanzi; K Marzloff; R Barbour; D Schenk
Journal of neuropathology and experimental neurology 1992;51(1):76-83. -
232.
1991S F Finn; B T Hyman; E Storey; J M Miller; M F Beal
Effects of aging on quinolinic acid lesions in rat striatum.
Brain research 1991;562(2):276-80. -
233.
1991L A Farrer; R H Myers; L Connor; L A Cupples; J H Growdon
Segregation analysis reveals evidence of a major gene for Alzheimer disease.
American journal of human genetics 1991;48(6):1026-33. -
234.
1991L A Farrer; L A Cupples; L Connor; P A Wolf; J H Growdon
Archives of neurology 1991;48(6):599-604. -
235.
1991M M Keane; J D Gabrieli; A C Fennema; J H Growdon; S Corkin
Evidence for a dissociation between perceptual and conceptual priming in Alzheimer's disease.
Behavioral neuroscience 1991;105(2):326-42. -
236.
1991P V Arriagada; D N Louis; E T Hedley-Whyte; B T Hyman
Neurofibrillary tangles and olfactory dysgenesis.
Lancet 1991;337(8740):559. -
237.
1991N W Kowall; M F Beal
Annals of neurology 1991;29(2):162-7. -
238.
1991A Kumar; M B Schapiro; C L Grady; M F Matocha; J V Haxby; A M Moore; J S Luxenberg; P H St George-Hyslop; C D Robinette; M J Ball
Archives of neurology 1991;48(2):160-8. -
239.
1991R Nitsch; A Pittas; J K Blusztajn; B E Slack; J H Growdon; R J Wurtman
Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():110-3. -
240.
1991B T Hyman; P V Arriagada; G W Van Hoesen
Pathologic changes in the olfactory system in aging and Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():14-9. -
241.
1991A Cronin-Golomb; J F Rizzo; S Corkin; J H Growdon
Visual function in Alzheimer's disease and normal aging.
Annals of the New York Academy of Sciences 1991;640():28-35. -
242.
1991A Cronin-Golomb; S Corkin; J F Rizzo; J Cohen; J H Growdon; K S Banks
Visual dysfunction in Alzheimer's disease: relation to normal aging.
Annals of neurology 1991;29(1):41-52. -
243.
1990J K Blusztajn; I Lopez Gonzalez-Coviella; M Logue; J H Growdon; R J Wurtman
Brain research 1990;536(1-2):240-4. -
244.
1990M F Beal
Somatostatin in neurodegenerative illnesses.
Metabolism: clinical and experimental 1990;39(9 Suppl 2):116-9. -
245.
1990M F Beal; U MacGarvey; K J Swartz
Galanin immunoreactivity is increased in the nucleus basalis of Meynert in Alzheimer's disease.
Annals of neurology 1990;28(2):157-61. -
246.
1990K A Johnson; B L Holman; T J Rosen; J S Nagel; R J English; J H Growdon
Archives of internal medicine 1990;150(4):752-6. -
247.
1990L A Farrer; R H Myers; L A Cupples; P H St George-Hyslop; T D Bird; M N Rossor; M J Mullan; R Polinsky; L Nee; L Heston
Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity.
Neurology 1990;40(3 Pt 1):395-403. -
248.
1989A Pitkänen; M F Beal; J Sirviö; K J Swartz; P T Männistö; P J Riekkinen
Neuropeptides 1989;14(3):197-207. -
249.
1989P H St George-Hyslop; R H Myers; J L Haines; L A Farrer; R E Tanzi; K Abe; M F James; P M Conneally; R J Polinsky; J F Gusella
Familial Alzheimer's disease: progress and problems.
Neurobiology of aging 1989;10(5):417-25. -
250.
1989S M de la Monte; S E Wells; T Hedley-Whyte; J H Growdon
Neuropathological distinction between Parkinson's dementia and Parkinson's plus Alzheimer's disease.
Annals of neurology 1989;26(3):309-20. -
251.
1989R A Clevens; M F Beal
Brain research 1989;486(2):387-90. -
252.
1989L A Farrer; D M O'Sullivan; L A Cupples; J H Growdon; R H Myers
Assessment of genetic risk for Alzheimer's disease among first-degree relatives.
Annals of neurology 1989;25(5):485-93. -
253.
1989R E Tanzi; P H St George-Hyslop; J F Gusella
Molecular genetic approaches to Alzheimer's disease.
Trends in neurosciences 1989;12(4):152-8. -
254.
1989N W Kowall; M F Beal
Neuroscience letters 1989;98(1):118-23. -
255.
1989N W Kowall; W W Pendlebury; J B Kessler; D P Perl; M F Beal
Neuroscience 1989;29(2):329-37. -
256.
1988M F Beal; R A Clevens; G K Chattha; U M MacGarvey; M F Mazurek; S M Gabriel
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257.
1988S J Zottoli; K J Rhodes; J G Corrodi; E J Mufson
The Journal of comparative neurology 1988;273(3):385-98. -
258.
1988M F Beal; S M Gabriel; K J Swartz; U M MacGarvey
Distribution of galanin-like immunoreactivity in baboon brain.
Peptides 1988;9(4):847-51. -
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1988E J Mufson; R Benoit; M M Mesulam
Brain research 1988;453(1-2):117-28. -
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1988N W Kowall; M F Beal
Annals of neurology 1988;23(2):105-14. -
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1988E J Mufson; M G Cunningham
Observations on choline acetyltransferase containing structures in the CD-1 mouse brain.
Neuroscience letters 1988;84(1):7-12. -
262.
1988M F Beal; R A Clevens; M F Mazurek
Synapse (New York, N.Y.) 1988;2(4):463-7. -
263.
1987K A Johnson; K R Davis; F S Buonanno; T J Brady; T J Rosen; J H Growdon
Comparison of magnetic resonance and roentgen ray computed tomography in dementia.
Archives of neurology 1987;44(10):1075-80. -
264.
1987M F Beal; M F Mazurek; M A McKee
Neuroscience letters 1987;79(1-2):201-6. -
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1987E J Mufson; A D Kehr; B H Wainer; M M Mesulam
Brain research 1987;417(2):385-8. -
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1987D W Ellison; M F Beal; J B Martin
Phosphoethanolamine and ethanolamine are decreased in Alzheimer's disease and Huntington's disease.
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267.
1987M F Beal; M F Mazurek
Substance P-like immunoreactivity is reduced in Alzheimer's disease cerebral cortex.
Neurology 1987;37(7):1205-9. -
268.
1987M M Mesulam; E J Mufson; J Rogers
Age-related shrinkage of cortically projecting cholinergic neurons: a selective effect.
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A comparison of somatostatin and neuropeptide Y distribution in monkey brain.
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Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
Science (New York, N.Y.) 1987;235(4791):873-7. -
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1987M A Morán; E J Mufson; M M Mesulam
Neural inputs into the temporopolar cortex of the rhesus monkey.
The Journal of comparative neurology 1987;256(1):88-103. -
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1987E J Mufson; R Labbe; D G Stein
Brain research 1987;401(1):162-7. -
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Neuropeptides in Alzheimer's disease.
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1987D G Stein; E J Mufson
Annals of the New York Academy of Sciences 1987;495():444-64. -
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1987S J Zottoli; K J Rhodes; E J Mufson
Brain, behavior and evolution 1987;30(3-4):143-59. -
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Comparison of rates of progression in Alzheimer's disease and Parkinson's disease.
Journal of neural transmission. Supplementum 1987;24():105-7. -
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Abstract reasoning in age-related neurological disease.
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1986M F Beal; M F Mazurek; J B Martin
Somatostatin immunoreactivity is reduced in Parkinson's disease dementia with Alzheimer's changes.
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Biological psychiatry 1986;21(11):1077-81. -
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1986M F Beal; M F Mazurek; G K Chattha; C N Svendsen; E D Bird; J B Martin
Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer's disease.
Annals of neurology 1986;20(3):282-8. -
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1986M F Beal; G K Chattha; J B Martin
A comparison of regional somatostatin and neuropeptide Y distribution in rat striatum and brain.
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1986E J Mufson; T L Martin; D C Mash; B H Wainer; M M Mesulam
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1986M F Beal; V T Tran; M F Mazurek; G Chattha; J B Martin
Somatostatin binding sites in human and monkey brain: localization and characterization.
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1986M M Mesulam; L Volicer; J K Marquis; E J Mufson; R C Green
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1986M F Beal; G Uhl; M F Mazurek; N Kowall; J B Martin
Somatostatin: alterations in the central nervous system in neurological diseases.
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1985M F Beal; M F Mazurek; P M Black; J B Martin
Human cerebrospinal fluid somatostatin in neurologic disease.
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1985M F Beal; M F Mazurek; V T Tran; G Chattha; E D Bird; J B Martin
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Scientific Context
This section shows information that has been computed by using the fingerprint of the grant, including related publications, related experts and related grants - all with fingerprints representing significant amounts of overlap between their fingerprint and this grant. The red dots indicate whether those experts or terms actually appear within this grant, showing potential and actual connections.
Related Grants
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1.
HYMAN, BRADLEY T
Massachusetts Alzheimer's Disease Research Center
1 April 1997 - 31 March 2014
NATIONAL INSTITUTE ON AGING
Total Funding: $ 13,238,070
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2.
MORRIS, JOHN
Dominantly Inherited Alzheimer Network
15 September 2008 - 31 December 2014
NATIONAL INSTITUTE ON AGING
Total Funding: $ 7,754,374
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TERI, LINDA
From Evidence-Base to Practice: Implementing RDAD in AAA Community-Based Services
1 April 2012 - 31 March 2017
NATIONAL INSTITUTE ON AGING
Total Funding: $ 455,712
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