Mufson, Elliott J

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Genetic Epidemiology of Alzheimer's Disease in Hispanics

1 December 1998 - 31 January 2014
NATIONAL INSTITUTE ON AGING
Total Funding: $ 9,751,270

53 Resulting Publications

• 1.

  2013

  Patrick Holton; Mina Ryten; Michael Nalls; Daniah Trabzuni; Michael E Weale; Dena Hernandez; Helen Crehan; J Raphael Gibbs; Richard Mayeux; Jonathan L Haines; et al.

  Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.

  Annals of human genetics 2013;77(2):85-105.

• 2.

  2013

  Devangere Devanand; Joseph Lee; Jose Luchsinger; Jennifer Manly; Karen Marder; Richard Mayeux; Nikolaos Scarmeas; Nicole Schupf; Yaakov Stern

  Lessons from epidemiologic research about risk factors, modifiers, and progression of late onset Alzheimer's Disease in New York City at Columbia University Medical Center.

  Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S447-55.

• 3.

  2013

  Badri Vardarajan; David Vergote; Fadel Tissir; Mark Logue; Jing Yang; Nathalie Daude; Kunie Ando; Ekaterina Rogaeva; Joseph Lee; Rong Cheng; et al.

  Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts.

  Molecular neurodegeneration 2013;8():10.

• 4.

  2012

  Gyungah Jun; Badri N Vardarajan; Jacqueline Buros; Chang-En Yu; Michele V Hawk; Beth A Dombroski; Paul K Crane; Eric B Larson; ; Richard Mayeux; et al.

  Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.

  Archives of neurology 2012;69(10):1270-9.

• 5.

  2012

  Christiane Reitz; Christopher Conrad; Katherine Roszkowski; Robert S Rogers; Richard Mayeux

  Effect of genetic variation in LRRTM3 on risk of Alzheimer disease.

  Archives of neurology 2012;69(7):894-900.

• 6.

  2012

  Christiane Reitz; Rong Cheng; Nicole Schupf; Joseph H Lee; Pankaj D Mehta; Ekaterina Rogaeva; Peter St George-Hyslop; Richard Mayeux

  Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels.

  Neurobiology of aging 2012;33(1):199.e13-7.

• 7.

  2012

  Carlos Cruchaga; Gabe Haller; Sumitra Chakraverty; Kevin Mayo; Francesco L M Vallania; Robi D Mitra; Kelley Faber; Jennifer Williamson; Tom Bird; Ramon Diaz-Arrastia; et al.

  Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families.

  PloS one 2012;7(2):e31039.

• 8.

  2012

  Fanggeng Zou; High Seng Chai; Curtis S Younkin; Mariet Allen; Julia Crook; V Shane Pankratz; Minerva M Carrasquillo; Christopher N Rowley; Asha A Nair; Sumit Middha; et al.

  Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.

  PLoS genetics 2012;8(6):e1002707.

• 9.

  2012

  Christiane Reitz; Giuseppe Tosto; Richard Mayeux; Jose A Luchsinger; ;

  Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease.

  PloS one 2012;7(12):e50354.

• 10.

  2011

  Richard Mayeux; Nicole Schupf

  Blood-based biomarkers for Alzheimer's disease: plasma Aβ40 and Aβ42, and genetic variants.

  Neurobiology of aging 2011;32 Suppl 1():S10-9.

• 11.

  2011

  Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; et al.

  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

  Nature genetics 2011;43(5):436-41.

• 12.

  2011

  Joseph H Lee; Rong Cheng; Sandra Barral; Christiane Reitz; Martin Medrano; Rafael Lantigua; Ivonne Z Jiménez-Velazquez; Ekaterina Rogaeva; Peter H St George-Hyslop; Richard Mayeux

  Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals.

  Archives of neurology 2011;68(3):320-8.

• 13.

  2011

  Christiane Reitz; Carol Brayne; Richard Mayeux

  Epidemiology of Alzheimer disease.

  Nature reviews. Neurology 2011;7(3):137-52.

• 14.

  2011

  Ellen M Wijsman; Nathan D Pankratz; Yoonha Choi; Joseph H Rothstein; Kelley M Faber; Rong Cheng; Joseph H Lee; Thomas D Bird; David A Bennett; Ramon Diaz-Arrastia; et al.

  Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.

  PLoS genetics 2011;7(2):e1001308.

• 15.

  2011

  Angela Nervi; Christiane Reitz; Ming-Xin Tang; Vincent Santana; Angel Piriz; Dolly Reyes; Rafael Lantigua; Martin Medrano; Ivonne Z Jiménez-Velázquez; Joseph H Lee; et al.

  Familial aggregation of dementia with Lewy bodies.

  Archives of neurology 2011;68(1):90-3.

• 16.

  2011

  Christiane Reitz; Rong Cheng; Ekaterina Rogaeva; Joseph H Lee; Shinya Tokuhiro; Fanggeng Zou; Karolien Bettens; Kristel Sleegers; Eng King Tan; Ryo Kimura; et al.

  Meta-analysis of the association between variants in SORL1 and Alzheimer disease.

  Archives of neurology 2011;68(1):99-106.

• 17.

  2011

  Christiane Reitz; Shinya Tokuhiro; Lorraine N Clark; Christopher Conrad; Jean-Paul Vonsattel; Lili-Naz Hazrati; András Palotás; Raphael Lantigua; Martin Medrano; Ivonne Z Jiménez-Velázquez; et al.

  SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.

  Annals of neurology 2011;69(1):47-64.

• 18.

  2011

  Fei Song; Anne Poljak; Michael Valenzuela; Richard Mayeux; George A Smythe; Perminder S Sachdev

  Meta-analysis of plasma amyloid-β levels in Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 2011;26(2):365-75.

• 19.

  2011

  Christiane Reitz; Joseph H Lee; Robert S Rogers; Richard Mayeux

  Impact of genetic variation in SORCS1 on memory retention.

  PloS one 2011;6(10):e24588.

• 20.

  2010

  Gyungah Jun; Adam C Naj; Gary W Beecham; Li-San Wang; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Nilufer Ertekin-Taner; M Daniele Fallin; Robert Friedland; et al.

  Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.

  Archives of neurology 2010;67(12):1473-84.

• 21.

  2010

  Christiane Reitz; Richard Mayeux

  Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia.

  Journal of Alzheimer's disease : JAD 2010;19(1):229-51.

• 22.

  2009

  C Reitz; R Mayeux

  Endophenotypes in normal brain morphology and Alzheimer's disease: a review.

  Neuroscience 2009;164(1):174-90.

• 23.

  2009

  Christiane Reitz; Richard Mayeux

  Use of genetic variation as biomarkers for Alzheimer's disease.

  Annals of the New York Academy of Sciences 2009;1180():75-96.

• 24.

  2009

  Lorraine N Clark; Lykourgos A Kartsaklis; Rebecca Wolf Gilbert; Beatriz Dorado; Barbara M Ross; Sergey Kisselev; Miguel Verbitsky; Helen Mejia-Santana; Lucien J Cote; Howard Andrews; et al.

  Association of glucocerebrosidase mutations with dementia with lewy bodies.

  Archives of neurology 2009;66(5):578-83.

• 25.

  2009

  Richard Mayeux; Peter St George-Hyslop

  Brain traffic: subcellular transport of the amyloid precursor protein.

  Archives of neurology 2009;66(4):433-4.

• 26.

  2008

  Angela Nervi; Christiane Reitz; Ming-Xin Tang; Vincent Santana; Angel Piriz; Dolly Reyes-Dumeyer; Rafael Lantigua; Martin Medrano; Ivonne Z Jiménez-Velázquez; Joseph H Lee; et al.

  Comparison of clinical manifestations in Alzheimer disease and dementia with Lewy bodies.

  Archives of neurology 2008;65(12):1634-9.

• 27.

  2008

  Joseph H Lee; Rong Cheng; Neill Graff-Radford; Tatiana Foroud; Richard Mayeux;

  Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci.

  Archives of neurology 2008;65(11):1518-26.

• 28.

  2008

  Joseph H Lee; Rong Cheng; Ekaterina Rogaeva; Yan Meng; Yaakov Stern; Vincent Santana; Rafael Lantigua; Martin Medrano; Ivonne Z Jimenez-Velazquez; Lindsay A Farrer; et al.

  Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.

  Neurogenetics 2008;9(2):127-38.

• 29.

  2008

  J H Lee; R Cheng; L S Honig; J-P G Vonsattel; L Clark; R Mayeux

  Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease.

  Neurology 2008;70(11):887-9.

• 30.

  2008

  Joseph H Lee; Sandra Barral; Rong Cheng; Inara Chacon; Vincent Santana; Jennifer Williamson; Rafael Lantigua; Martin Medrano; Ivonne Z Jimenez-Velazquez; Yaakov Stern; et al.

  Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer's disease.

  Neurogenetics 2008;9(1):51-60.

• 31.

  2008

  Richard Mayeux; Peter St George Hyslop

  Alzheimer's disease: advances in trafficking.

  Lancet neurology 2008;7(1):2-3.

• 32.

  2008

  Joseph H Lee; Nobuto Shibata; Rong Cheng; Richard Mayeux

  Possible association between SORL1 and Alzheimer disease? Reanalysing the data of Shibata et al.

  Dementia and geriatric cognitive disorders 2008;26(5):482.

• 33.

  2007

  Yan Meng; Joseph H Lee; Rong Cheng; Peter St George-Hyslop; Richard Mayeux; Lindsay A Farrer

  Association between SORL1 and Alzheimer's disease in a genome-wide study.

  Neuroreport 2007;18(17):1761-4.

• 34.

  2007

  Nobuto Shibata; Toshitaka Kawarai; Yan Meng; Joseph H Lee; Hye-Seung Lee; Yosuke Wakutani; Eri Shibata; Nazia Pathan; Andrew Bi; Christine Sato; et al.

  Association studies between the plasmin genes and late-onset Alzheimer's disease.

  Neurobiology of aging 2007;28(7):1041-3.

• 35.

  2007

  Jennifer Williamson; Jill S Goldman; Richard Mayeux

  Genetic research and genetic testing in Alzheimer's disease: a view from the bridge.

  Nature clinical practice. Neurology 2007;3(7):356-7.

• 36.

  2007

  Joseph H Lee; Rong Cheng; Nicole Schupf; Jennifer Manly; Rafael Lantigua; Yaakov Stern; Ekaterina Rogaeva; Yosuke Wakutani; Lindsay Farrer; Peter St George-Hyslop; et al.

  The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort.

  Archives of neurology 2007;64(4):501-6.

• 37.

  2007

  Ekaterina Rogaeva; Yan Meng; Joseph H Lee; Yongjun Gu; Toshitaka Kawarai; Fanggeng Zou; Taiichi Katayama; Clinton T Baldwin; Rong Cheng; Hiroshi Hasegawa; et al.

  The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.

  Nature genetics 2007;39(2):168-77.

• 38.

  2007

  Beverly Johnson; Vincent Santana; Nicole Schupf; Ming-X Tang; Yaakov Stern; Richard Mayeux; Joseph H Lee

  The heritability of abstract reasoning in Caribbean Latinos with familial Alzheimer disease.

  Dementia and geriatric cognitive disorders 2007;24(6):411-7.

• 39.

  2007

  Joseph H Lee; Richard Mayeux

  Genetics and its use in Alzheimer's disease.

  Psychopharmacology bulletin 2007;40(4):132-44.

• 40.

  2006

  Joseph H Lee; Rong Cheng; Vincent Santana; Jennifer Williamson; Rafael Lantigua; Martin Medrano; Alex Arriaga; Yaakov Stern; Benjamin Tycko; Ekaterina Rogaeva; et al.

  Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease.

  Archives of neurology 2006;63(11):1591-8.

• 41.

  2006

  Richard Mayeux

  Genetic epidemiology of Alzheimer disease.

  Alzheimer disease and associated disorders 2006;20(3 Suppl 2):S58-62.

• 42.

  2006

  G A Rippon; M X Tang; J H Lee; R Lantigua; M Medrano; R Mayeux

  Familial Alzheimer disease in Latinos: interaction between APOE, stroke, and estrogen replacement.

  Neurology 2006;66(1):35-40.

• 43.

  2006

  Nobuto Shibata; Toshitaka Kawarai; Joseph H Lee; Hye-Seung Lee; Eri Shibata; Christine Sato; Yan Liang; Rajan Duara; Richard P Mayeux; Peter H St George-Hyslop; et al.

  Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.

  Neuroscience letters 2006;391(3):142-6.

• 44.

  2004

  J H Lee; R Mayeux; D Mayo; J Mo; V Santana; J Williamson; A Flaquer; A Ciappa; H Rondon; P Estevez; et al.

  Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics.

  Molecular psychiatry 2004;9(11):1042-51.

• 45.

  2004

  Benjamin Tycko; Joseph H Lee; Alejandra Ciappa; Anjana Saxena; Chi-Ming Li; Lin Feng; Alex Arriaga; Yaakov Stern; Rafael Lantigua; Neil Shachter; et al.

  APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals.

  Archives of neurology 2004;61(9):1434-9.

• 46.

  2004

  J H Lee; A Flaquer; Y Stern; B Tycko; R Mayeux

  Genetic influences on memory performance in familial Alzheimer disease.

  Neurology 2004;62(3):414-21.

• 47.

  2003

  James L Kennedy; Lindsay A Farrer; Nancy C Andreasen; Richard Mayeux; Peter St George-Hyslop

  The genetics of adult-onset neuropsychiatric disease: complexities and conundra?

  Science (New York, N.Y.) 2003;302(5646):822-6.

• 48.

  2002

  R Mayeux; J H Lee; S N Romas; D Mayo; V Santana; J Williamson; A Ciappa; H Z Rondon; P Estevez; R Lantigua; et al.

  Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics.

  American journal of human genetics 2002;70(1):237-43.

• 49.

  2002

  Stavra N Romas; Vincent Santana; Jennifer Williamson; Alejandra Ciappa; Joseph H Lee; Haydee Z Rondon; Pedro Estevez; Rafael Lantigua; Martin Medrano; Mayobanex Torres; et al.

  Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE.

  Archives of neurology 2002;59(1):87-91.

• 50.

  2001

  E S Athan; J Williamson; A Ciappa; V Santana; S N Romas; J H Lee; H Rondon; R A Lantigua; M Medrano; M Torres; et al.

  A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families.

  JAMA : the journal of the American Medical Association 2001;286(18):2257-63.

• 51.

  2000

  G Devi; A Fotiou; D Jyrinji; B Tycko; S DeArmand; E Rogaeva; Y Q Song; H Medieros; Y Liang; A Orlacchio; et al.

  Novel presenilin 1 mutations associated with early onset of dementia in a family with both early-onset and late-onset Alzheimer disease.

  Archives of neurology 2000;57(10):1454-7.

• 52.

  2000

  S N Romas; R Mayeux; M X Tang; R Lantigua; M Medrano; B Tycko; J Knowles

  No association between a presenilin 1 polymorphism and Alzheimer disease.

  Archives of neurology 2000;57(5):699-702.

• 53.

  2000

  S N Romas; R Mayeux; D Rabinowitz; M X Tang; H R Zadroga; R Lantigua; M Medrano; B Tycko; J A Knowles

  The deletion polymorphism and Val1000Ile in alpha-2-macroglobulin and Alzheimer disease in Caribbean Hispanics.

  Neuroscience letters 2000;279(3):133-6.

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