Hyman, Bradley T

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Structural Biology of Amyloid Beta-Protein

10 December 1998 - 28 February 2015
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Total Funding: $ 3,633,629

46 Resulting Publications

• 1.

  2013

  Zhengjian Lv; Margaret M Condron; David B Teplow; Yuri L Lyubchenko

  Nanoprobing of the effect of Cu(2+) cations on misfolding, interaction and aggregation of amyloid β peptide.

  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2013;8(1):262-73.

• 2.

  2013

  Robin Roychaudhuri; Mingfeng Yang; Atul Deshpande; Gregory M Cole; Sally Frautschy; Aleksey Lomakin; George B Benedek; David B Teplow

  C-terminal turn stability determines assembly differences between Aβ40 and Aβ42.

  Journal of molecular biology 2013;425(2):292-308.

• 3.

  2013

  Mathew T Mizwicki; Guanghao Liu; Milan Fiala; Larry Magpantay; James Sayre; Avi Siani; Michelle Mahanian; Rachel Weitzman; Eric Y Hayden; Mark J Rosenthal; et al.

  1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients.

  Journal of Alzheimer's disease : JAD 2013;34(1):155-70.

• 4.

  2012

  Megan Murray Gessel; Summer Bernstein; Martin Kemper; David B Teplow; Michael T Bowers

  Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization.

  ACS chemical neuroscience 2012;3(11):909-18.

• 5.

  2012

  L Cruz; J Srinivasa Rao; D B Teplow; B Urbanc

  Dynamics of metastable β-hairpin structures in the folding nucleus of amyloid β-protein.

  The journal of physical chemistry. B 2012;116(22):6311-25.

• 6.

  2012

  Robin Roychaudhuri; Mingfeng Yang; Margaret M Condron; David B Teplow

  Structural dynamics of the amyloid β-protein monomer folding nucleus.

  Biochemistry 2012;51(19):3957-9.

• 7.

  2012

  Clark Rosensweig; Kenjiro Ono; Kazuma Murakami; Devin K Lowenstein; Gal Bitan; David B Teplow

  Preparation of stable amyloid β-protein oligomers of defined assembly order.

  Methods in molecular biology (Clifton, N.J.) 2012;849():23-31.

• 8.

  2011

  Mohammed Inayathullah; David B Teplow

  Structural dynamics of the ΔE22 (Osaka) familial Alzheimer's disease-linked amyloid β-protein.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2011;18(3):98-107.

• 9.

  2009

  Akihiko Noguchi; Satoko Matsumura; Mari Dezawa; Mari Tada; Masako Yanazawa; Akane Ito; Manami Akioka; Satoru Kikuchi; Michio Sato; Shouji Ideno; et al.

  Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

  The Journal of biological chemistry 2009;284(47):32895-905.

• 10.

  2009

  Robin Roychaudhuri; Mingfeng Yang; Minako M Hoshi; David B Teplow

  Amyloid beta-protein assembly and Alzheimer disease.

  The Journal of biological chemistry 2009;284(8):4749-53.

• 11.

  2008

  Regina Fluhrer; Akio Fukumori; Lucas Martin; Gudula Grammer; Martina Haug-Kröper; Bärbel Klier; Edith Winkler; Elisabeth Kremmer; Margaret M Condron; David B Teplow; et al.

  Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.

  The Journal of biological chemistry 2008;283(44):30121-8.

• 12.

  2007

  Marianne A Grant; Noel D Lazo; Aleksey Lomakin; Margaret M Condron; Hiromi Arai; Ghiam Yamin; Alan C Rigby; David B Teplow

  Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus.

  Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16522-7.

• 13.

  2007

  Sijung Yun; B Urbanc; L Cruz; G Bitan; D B Teplow; H E Stanley

  Role of electrostatic interactions in amyloid beta-protein (A beta) oligomer formation: a discrete molecular dynamics study.

  Biophysical journal 2007;92(11):4064-77.

• 14.

  2007

  Yukiko Hori; Tadafumi Hashimoto; Yosuke Wakutani; Katsuya Urakami; Kenji Nakashima; Margaret M Condron; Satoshi Tsubuki; Takaomi C Saido; David B Teplow; Takeshi Iwatsubo

  The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation.

  The Journal of biological chemistry 2007;282(7):4916-23.

• 15.

  2006

  Brigita Urbanc; Luis Cruz; David B Teplow; H Eugene Stanley

  Computer simulations of Alzheimer's amyloid beta-protein folding and assembly.

  Current Alzheimer research 2006;3(5):493-504.

• 16.

  2006

  David B Teplow; Noel D Lazo; Gal Bitan; Summer Bernstein; Thomas Wyttenbach; Michael T Bowers; Andrij Baumketner; Joan-Emma Shea; Brigita Urbanc; Luis Cruz; et al.

  Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach.

  Accounts of chemical research 2006;39(9):635-45.

• 17.

  2006

  Regina Fluhrer; Gudula Grammer; Lars Israel; Margaret M Condron; Christof Haffner; Elena Friedmann; Claudia Böhland; Axel Imhof; Bruno Martoglio; David B Teplow; et al.

  A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.

  Nature cell biology 2006;8(8):894-6.

• 18.

  2006

  Andrij Baumketner; Summer L Bernstein; Thomas Wyttenbach; Noel D Lazo; David B Teplow; Michael T Bowers; Joan-Emma Shea

  Structure of the 21-30 fragment of amyloid beta-protein.

  Protein science : a publication of the Protein Society 2006;15(6):1239-47.

• 19.

  2006

  Andrij Baumketner; Summer L Bernstein; Thomas Wyttenbach; Gal Bitan; David B Teplow; Michael T Bowers; Joan-Emma Shea

  Amyloid beta-protein monomer structure: a computational and experimental study.

  Protein science : a publication of the Protein Society 2006;15(3):420-8.

• 20.

  2006

  Uvidelio F Castillo; Gary A Strobel; Kirby Mullenberg; Margaret M Condron; David B Teplow; Vincenzo Folgiano; Monica Gallo; Rosalia Ferracane; Luisa Mannina; Stepanie Viel; et al.

  Munumbicins E-4 and E-5: novel broad-spectrum antibiotics from Streptomyces NRRL 3052.

  FEMS microbiology letters 2006;255(2):296-300.

• 21.

  2006

  Aleksey Lomakin; David B Teplow

  Quasielastic light scattering study of amyloid beta-protein fibril formation.

  Protein and peptide letters 2006;13(3):247-54.

• 22.

  2006

  David B Teplow

  Preparation of amyloid beta-protein for structural and functional studies.

  Methods in enzymology 2006;413():20-33.

• 23.

  2005

  Luis Cruz; Brigita Urbanc; Jose M Borreguero; Noel D Lazo; David B Teplow; H Eugene Stanley

  Solvent and mutation effects on the nucleation of amyloid beta-protein folding.

  Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18258-63.

• 24.

  2005

  Samir K Maji; Jason J Amsden; Kenneth J Rothschild; Margaret M Condron; David B Teplow

  Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence.

  Biochemistry 2005;44(40):13365-76.

• 25.

  2005

  Noel D Lazo; Marianne A Grant; Margaret C Condron; Alan C Rigby; David B Teplow

  On the nucleation of amyloid beta-protein monomer folding.

  Protein science : a publication of the Protein Society 2005;14(6):1581-96.

• 26.

  2005

  Gal Bitan; Erica A Fradinger; Sean M Spring; David B Teplow

  Neurotoxic protein oligomers--what you see is not always what you get.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2005;12(2):88-95.

• 27.

  2005

  Jose M Borreguero; Brigita Urbanc; Noel D Lazo; Sergey V Buldyrev; David B Teplow; H Eugene Stanley

  Folding events in the 21-30 region of amyloid beta-protein (Abeta) studied in silico.

  Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6015-20.

• 28.

  2005

  Summer L Bernstein; Thomas Wyttenbach; Andrij Baumketner; Joan-Emma Shea; Gal Bitan; David B Teplow; Michael T Bowers

  Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform.

  Journal of the American Chemical Society 2005;127(7):2075-84.

• 29.

  2005

  Gal Bitan; David B Teplow

  Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays.

  Methods in molecular biology (Clifton, N.J.) 2005;299():3-9.

• 30.

  2005

  Sabrina S Vollers; David B Teplow; Gal Bitan

  Determination of Peptide oligomerization state using rapid photochemical crosslinking.

  Methods in molecular biology (Clifton, N.J.) 2005;299():11-8.

• 31.

  2005

  Aleksey Lomakin; David B Teplow; George B Benedek

  Quasielastic light scattering for protein assembly studies.

  Methods in molecular biology (Clifton, N.J.) 2005;299():153-74.

• 32.

  2004

  B Urbanc; L Cruz; S Yun; S V Buldyrev; G Bitan; D B Teplow; H E Stanley

  In silico study of amyloid beta-protein folding and oligomerization.

  Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17345-50.

• 33.

  2004

  Gal Bitan; David B Teplow

  Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies.

  Accounts of chemical research 2004;37(6):357-64.

• 34.

  2004

  W L Klein; W B Stine; D B Teplow

  Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease.

  Neurobiology of aging 2004;25(5):569-80.

• 35.

  2003

  Gal Bitan; Bogdan Tarus; Sabrina S Vollers; Hilal A Lashuel; Margaret M Condron; John E Straub; David B Teplow

  A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization.

  Journal of the American Chemical Society 2003;125(50):15359-65.

• 36.

  2003

  Gal Bitan; Sabrina S Vollers; David B Teplow

  Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization.

  The Journal of biological chemistry 2003;278(37):34882-9.

• 37.

  2003

  Gal Bitan; Marina D Kirkitadze; Aleksey Lomakin; Sabrina S Vollers; George B Benedek; David B Teplow

  Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.

  Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):330-5.

• 38.

  2002

  Youcef Fezoui; David B Teplow

  Kinetic studies of amyloid beta-protein fibril assembly. Differential effects of alpha-helix stabilization.

  The Journal of biological chemistry 2002;277(40):36948-54.

• 39.

  2002

  Marina D Kirkitadze; Gal Bitan; David B Teplow

  Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies.

  Journal of neuroscience research 2002;69(5):567-77.

• 40.

  2001

  M D Kirkitadze; M M Condron; D B Teplow

  Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis.

  Journal of molecular biology 2001;312(5):1103-19.

• 41.

  2001

  G Bitan; A Lomakin; D B Teplow

  Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins.

  The Journal of biological chemistry 2001;276(37):35176-84.

• 42.

  2001

  C Nilsberth; A Westlind-Danielsson; C B Eckman; M M Condron; K Axelman; C Forsell; C Stenh; J Luthman; D B Teplow; S G Younkin; et al.

  The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.

  Nature neuroscience 2001;4(9):887-93.

• 43.

  2001

  D M Walsh; D M Hartley; M M Condron; D J Selkoe; D B Teplow

  In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.

  The Biochemical journal 2001;355(Pt 3):869-77.

• 44.

  2000

  Y Fezoui; D M Hartley; J D Harper; R Khurana; D M Walsh; M M Condron; D J Selkoe; P T Lansbury; A L Fink; D B Teplow

  An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments.

  Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2000;7(3):166-78.

• 45.

  1999

  D M Walsh; D M Hartley; Y Kusumoto; Y Fezoui; M M Condron; A Lomakin; G B Benedek; D J Selkoe; D B Teplow

  Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.

  The Journal of biological chemistry 1999;274(36):25945-52.

• 46.

  1999

  D J Watson; D J Selkoe; D B Teplow

  Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein.

  The Biochemical journal 1999;340 ( Pt 3)():703-9.

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