The grant detail shows the name of the PI, active dates of the project, the funding institute and the abstract of the grant. This abstract is what is used to create the fingerprint of the grant. If any publications referencing this grant are found in the data, they will be listed here as well.
EPIDEMIOLOGY OF DEMENTIA IN OLDER JAPANESE AMERICANS
1 May 1991 - 30 April 2003
NATIONAL INSTITUTE ON AGING
Total Funding: $ 9,071,109
Existing studies suggest that, while the overall prevalence rates of dementia in Japan and the U.S. are similar, the relative prevalence of Alzheimer's disease (AD) to vascular dementia (VaD) is much greater in the U.S. It is not known whether these differences result from differing study methods or whether they reflect underlying differences in the incidence of dementia subtypes in the two countries with concomitant differences in genetic susceptibility and/or exposure to environmental risk factors. Results from a prevalence survey of a total population of Japanese-Americans aged 65 and over living in King County, WA show that prevalence rates more closely resemble those of Caucasian populations than native Japanese. We propose to (1) follow this cohort over the next five years to (2) determine age- and sex-specific incidence rates of dementia and its subtypes; (3) follow existing prevalent and developing incident cases to monitor the clinical and neuropsychological progression and describe survival in AD and VaD cases, (4) conduct prospective risk factor analyses, including survival analyses, of genetic (apolipoprotein E and family history) and environmental factors for AD and VaD, particularly those affected by lifestyle and diet, and examine potential interactions between genes and environment on the risk of dementia and its subtypes; (5) compare prevalence, incidence as well as relative and attributable risks with methodologically standardized studies in Honolulu, Hiroshima and Machida City. The baseline examination (1992- 1994) contained nearly 2,000 individuals; to cohort of cognitively intact persons contains approximately 1,650. The cognitively intact cohort will be screened every two years, the persons with cognitive impairment are followed annually. Pending the results of an analysis of our screening strategy during the currently funded grant period, we plan to screen the cognitively intact cohort every two years using a cutoff score of 81/100 on the Cognitive Abilities Screening Instrument (CASI) and/or a decline of 7 points at any CASI level, to estimate age and sex-specific incidence rates. Patients scoring below the cut scores will have routine, standardized neurologic and neuropsychological evaluations. The followup of the cohort to the year 2001 will yield approximately 127 new cases of dementia. Risk factors for dementia subtypes will be examined in this group, including possible protective factors which show preliminary associations with cognitive impairment and prevalent disease, such as estrogen therapy replacement, head circumference and the apolipoprotein E-e2 (apoE) allele. Changes over time in CASI scores in the cognitively intact cohort also will be analyzed with regard to apoE genotype and other host factors. Finally, standardization efforts between the study sites will focus on the enhancement of the uniformity of diagnostic methods, and cross-site data analysis to compare rates and risk factors.
24 Resulting Publications
Katherine W Snapinn; Eric B Larson; Hideshi Kawakami; Hiroshi Ujike; Amy R Borenstein; Yuishin Izumi; Ryuji Kaji; Hirofumi Maruyama; Ignacio F Mata; Hiroyuki Morino; et al.Parkinsonism & related disorders 2011;17(6):473-5.
Eric B LarsonInternational psychogeriatrics / IPA 2010;22(8):1196-202.
Qi Dai; Amy R Borenstein; Yougui Wu; James C Jackson; Eric B LarsonThe American journal of medicine 2006;119(9):751-9.
Gail E Bond; Robert L Burr; Susan M McCurry; Madeline Murguia Rice; Amy R Borenstein; Eric B LarsonInternational psychogeriatrics / IPA 2005;17(4):653-68.
Gail E Bond; Robert Burr; Susan M McCurry; Madeline Murguia Rice; Amy R Borenstein; Walter A Kukull; Linda Teri; James D Bowen; Wayne C McCormick; Eric B LarsonJournal of aging and health 2004;16(5):615-40.
Gail E Bond; Robert Burr; Madeline Murguia Rice; Susan M McCurry; Amy Borenstein Graves; Linda Teri; James D Bowen; Wayne C McCormick; Eric B LarsonJournal of aging and health 2003;15(2):371-90.
Wayne C McCormick; Cynthia Y Ohata; Jay Uomoto; Heather M Young; Amy B Graves; Walter Kukull; Linda Teri; Peter Vitaliano; James A Mortimer; Susan M McCurry; et al.Journal of the American Geriatrics Society 2002;50(6):1149-55.
Susan M McCurry; Laura E Gibbons; Gail E Bond; Madeline Murguia Rice; Amy Borenstein Graves; Walter A Kukull; Linda Teri; Roger Higdon; James D Bowen; Wayne C McCormick; et al.International psychogeriatrics / IPA 2002;14(2):161-79.
A Borenstein Graves; J A Mortimer; J D Bowen; W C McCormick; S M McCurry; G D Schellenberg; E B LarsonNeurology 2001;57(8):1453-60.
M M Rice; A Z LaCroix; J W Lampe; G van Belle; M Kestin; M Sumitani; A B Graves; E B LarsonPublic health nutrition 2001;4(5):943-52.
M F Shadlen; E B Larson; L E Gibbons; M M Rice; W C McCormick; J Bowen; S M McCurry; A B GravesJournal of the American Geriatrics Society 2001;49(10):1371-8.
G E Bond; R Burr; S M McCurry; A B Graves; E B LarsonInternational psychogeriatrics / IPA 2001;13(2):207-23.
M M Rice; A B Graves; S M McCurry; L E Gibbons; J D Bowen; W C McCormick; E B LarsonArchives of internal medicine 2000;160(11):1641-9.
A B Graves; J D Bowen; L Rajaram; W C McCormick; S M McCurry; G D Schellenberg; E B LarsonNeurology 1999;53(7):1480-7.
S M McCurry; S D Edland; L Teri; W A Kukull; J D Bowen; W C McCormick; E B LarsonInternational journal of geriatric psychiatry 1999;14(10):882-8.
M Snowden; W McCormick; J Russo; D Srebnik; K Comtois; J Bowen; L Teri; E B LarsonJournal of the American Geriatrics Society 1999;47(8):1000-4.
S D Edland; A B Graves; W C McCormick; E B LarsonJournal of clinical epidemiology 1999;52(5):399-403.
A B Graves; L Rajaram; J D Bowen; W C McCormick; S M McCurry; E B LarsonThe journals of gerontology. Series B, Psychological sciences and social sciences 1999;54(3):S154-61.
E B Larson; S M McCurry; A B Graves; J D Bowen; M M Rice; W C McCormick; N Zee; A Homma; Y Imai; L White; et al.The journals of gerontology. Series A, Biological sciences and medical sciences 1998;53(4):M313-9.
E B Larson; J K Edwards; E O'Meara; D Nochlin; S M SumiThe journals of gerontology. Series A, Biological sciences and medical sciences 1996;51(6):M313-8.
A B Graves; E B Larson; S D Edland; J D Bowen; W C McCormick; S M McCurry; M M Rice; A Wenzlow; J M UomotoAmerican journal of epidemiology 1996;144(8):760-71.
W C McCormick; J Uomoto; H Young; A B Graves; P Vitaliano; J A Mortimer; S D Edland; E B LarsonJournal of the American Geriatrics Society 1996;44(7):769-77.
A B Graves; J A Mortimer; E B Larson; A Wenzlow; J D Bowen; W C McCormickThe British journal of psychiatry : the journal of mental science 1996;169(1):86-92.
A B Graves; E B Larson; L R White; E L Teng; A HommaInternational psychogeriatrics / IPA 1994;6(2):209-23.
This section shows information that has been computed by using the fingerprint of the grant, including related publications, related experts and related grants - all with fingerprints representing significant amounts of overlap between their fingerprint and this grant. The red dots indicate whether those experts or terms actually appear within this grant, showing potential and actual connections.
GROWDON, JOHN H
1 January 1984 - 31 December 1986
NATIONAL INSTITUTE ON AGING
Total Funding: $ 374,277
Dekosky, Steven T
30 September 1999 - 31 July 2010
NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE
Total Funding: $ 30,761,491
MORRIS, JOHN C
5 February 1996 - 31 December 2001
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Total Funding: $ 1,529,999
Theodore K Malmstrom; Douglas K Miller; Mary A Coats; Pamela Jackson; J Philip Miller; John C MorrisAlzheimer disease and associated disorders 2009;23(2):117-23.
T Reed; D Carmelli; G E Swan; J C Breitner; K A Welsh; G P Jarvik; S Deeb; J AuwerxArchives of neurology 1994;51(12):1189-92.
B J Small; M Viitanen; B Winblad; L BäckmanJournal of clinical and experimental neuropsychology 1997;19(2):245-60.
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