Roses, Allen D

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BIOCHEMICAL STUDIES OF MEMBRANE PROTEINS IN DMD

Roses, Allen D

1 July 1977 - 30 June 1983
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Total Funding: $ 605,401

This research proposes to define a unique biochemical abnormality in erythrocyte membrane spectrin that is characteristic of and specific to x-linked Duchenne muscular dystrophy. Using the abnormally increased (32P)-phosphorylation of erythrocyte protein band II as a marker, methods of peptide mapping and isolation are proposed that involve a number of peptide cleavage techniques. Methods of analysis include gel filtration, stacking polyacrylamide gel electrophoresis, and reverse phase high performance liquid chromatography. This proposal is the next phase of a long-term project to define the biochemical defect in Duchenne dystrophy, to determine the pathogenesis of the disease, and to use these data to develop diagnostic methods for patients, carriers, and fetuses at risk.

7 Resulting Publications

• 1.

  1983

  R J Lane; M Robinow; A D Roses

  The genetic status of mothers of isolated cases of Duchenne muscular dystrophy.

  Journal of medical genetics 1983;20(1):1-11.

• 2.

  1981

  M E Mabry; A D Roses

  Increased [32P]-phosphorylation of tryptic peptides of erythrocyte spectrin in Duchenne muscular dystrophy.

  Muscle & nerve 1981;4(6):489-93.

• 3.

  1981

  A D Roses; P E Shile; M H Herbstreith; C V Balakrishnan

  Identification of abnormally [32P]-phosphorylated cyanogen bromide cleavage product of erythrocyte membrane spectrin in Duchenne muscular dystrophy.

  Neurology 1981;31(8):1026-30.

• 4.

  1981

  R J Lane; A D Roses

  Variation of serum creatine kinase levels with age in normal females: implications for genetic counselling in Duchenne muscular dystrophy.

  Clinica chimica acta; international journal of clinical chemistry 1981;113(1):75-86.

• 5.

  1981

  R L Wertz; G B Hartwig; A P Frost; J J Brophy; S K Atwater; A D Roses

  Patients with myotonic dystrophy, a possible segmental progeroid syndrome, and Duchenne muscular dystrophy have fibroblasts with normal limits for in vitro lifespan and growth characteristics.

  Journal of cellular physiology 1981;107(2):255-60.

• 6.

  1980

  Y Nagano; P Wong; A D Roses

  Altered erythrocyte spectrin extractability in Duchenne muscular dystrophy.

  Clinica chimica acta; international journal of clinical chemistry 1980;108(3):469-74.

• 7.

  1980

  Y Nagano; A D Roses

  Abnormalities of erythrocyte membranes in myotonic muscular dystrophy manifested in lipid vesicles.

  Neurology 1980;30(9):989-91.

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