• By Concept
  • By Last Name
  • By Full Text

Soininen, Hilkka

Grant Detail

The grant detail shows the name of the PI, active dates of the project, the funding institute and the abstract of the grant. This abstract is what is used to create the fingerprint of the grant. If any publications referencing this grant are found in the data, they will be listed here as well.



NEUROBIOLOGICAL STUDIES/ALZHEIMER'S/PARKINSON'S DISEASE

Price, Donald L

1 June 1982 - 31 August 1990
NATIONAL INSTITUTE ON AGING
Total Funding: $ 1,064,558

FY 1989
5R01AG003359-08
$ 110,210
FY 1988
5R01AG003359-07
$ 104,244
FY 1987
5R01AG003359-06
$ 99,241
FY 1986
5R01AG003359-05
$ 93,832
FY 1985
2R01AG003359-04
$ 90,986
FY 1984
5R01AG003359-03
$ 205,867
FY 1983
5R01AG003359-02
$ 200,524
FY 1982
1R01AG003359-01
$ 159,654
 
 
$ 1,064,558
Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common adult-onset degenerative disorders of the nervous system. Patients with AD and a substantial number of patients with PD develop dementia during the course of their illness. Although recent studies indicate that these disorders involve several neuronal populations, the cellular substrate for the memory deficits and abnormalities in cognitive processes, language, visual-spatial skills, and mood are not well understood. In both diseases, certain cell groups show neurofibrillary pathology, i.e., neurofibrillary tangles, Lewy bodies, and argentophilic neurites in senile plaques. Our work with experimental disorders of cytoskeletal pathology suggest that affected neurons in AD and PD exhibit abnormalities in the function of the cytoskeleton. Our research specifically addresses issues concerning the distribution and character of these pathological processes in relation to clinical disease. At The Johns Hopkins Medical Institutions, we have substantial numbers of patients with AD and PD who are well characterized by clinical examinations, neuropsychological tests, and in vitro imaging methods. Affected individuals provide an unusual opportunity to investigate the biology of brain pathology in carefully studied individuals with AD or PD. Using a variety of approaches (immunohistochemistry/histochemistry, neurochemical assays, and computer-assisted imaging methods), we will investigate specific pathologies, including: the number and size of neurons in specific cell groups thought to be at risk in AD or PD; the distribution and density of plaques and tangles; and the distribution of transmitter markers and specific cytoskeletal elements within plaques and tangles. Using statistical approaches, our findings in the brain will be correlated with clinical findings in individual patients. The long-range goal of these investigations is to understand the mechanisms and consequences of specific cellular pathologies in AD and PD. Understanding these processes should lead to insights into the dynamics of disease, raise questions about etiological factors, and suggest rational approaches to therapy.

79 Resulting Publications

Scientific Context

This section shows information that has been computed by using the fingerprint of the grant, including related publications, related experts and related grants - all with fingerprints representing significant amounts of overlap between their fingerprint and this grant. The red dots indicate whether those experts or terms actually appear within this grant, showing potential and actual connections.

Related Grants

Related Publications