The grant detail shows the name of the PI, active dates of the project, the funding institute and the abstract of the grant. This abstract is what is used to create the fingerprint of the grant. If any publications referencing this grant are found in the data, they will be listed here as well.
MENTAL DISORDERS OF AGING--ANTIINFLAMMATION IN AD
1 December 1998 - 30 November 2005
NATIONAL INSTITUTE OF MENTAL HEALTH
Total Funding: $ 2,341,749
Several observational epidemiological studies indicate that anti- inflammatory treatments attenuate or prevent the symptoms of one of the most common mental disorders of late life, Alzheimer disease (AD). Neuropathological studies also support inflammatory or immune mechanisms in AD, including findings of reactive microglia within or near AD lesions. Such evidence, however, is circumstantial, and controlled, randomized drug trials are needed to determine efficacy. The proposed project is designed to determine if the commonly used non-steroidal anti-inflammatory drug (NSAID), ibuprofen, is efficacious in delaying progression of cognitive symptoms in people with age-related cognitive losses who are at risk for developing AD. A total of 135 subjects with age-associated memory impairment (AAMI) who are at risk for further cognitive decline (age 65 to 90 years, low scores on tests of verbal and visual memory and verbal fluency) will be randomized (double-blind design) to one of two treatment groups: ibuprofen (1200 mg/d) or placebo, and followed for two years for evidence of further cognitive decline. All randomized subjects will receive magnetic resonance imaging (MRI) scans and selective genotyping (apolipoprotein E [APOE] and human leukocyte antigen [HLA) to explore how baseline brain morphology (e.g., deep white matter disease hippocampal asymmetry and atrophy) and genetic risk for AD onset (e.g., APOE-4, HLA- A2) influence decline rates and treatment outcome. Subjects receiving ibuprofen are expected to show less evidence of cognitive decline than those receiving placebo. The proposed project builds upon our group's prior work on early detection of AD using brain imaging, genetic risk, and neuropsychological assessments. This project also is a logical follow-up to recent observation studies of a promising early intervention and will represent one of the first controlled, anti-inflammatory treatment trials for persons at high risk for age-related cognitive decline and the eventual development of AD.
5 Resulting Publications
Meredith N Braskie; Andrea D Klunder; Kiralee M Hayashi; Hillary Protas; Vladimir Kepe; Karen J Miller; S-C Huang; Jorge R Barrio; Linda M Ercoli; Prabha Siddarth; et al.Neurobiology of aging 2010;31(10):1669-78.
Liana G Apostolova; Paul M Thompson; Steve A Rogers; Ivo D Dinov; Charleen Zoumalan; Calen A Steiner; Erin Siu; Amity E Green; Gary W Small; Arthur W Toga; et al.Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2010;12(2):218-24.
H D Protas; S-C Huang; V Kepe; K Hayashi; A Klunder; M N Braskie; L Ercoli; S Bookheimer; P M Thompson; G W Small; et al.NeuroImage 2010;49(1):240-8.
Meredith N Braskie; Gary W Small; Susan Y BookheimerHuman brain mapping 2009;30(12):3981-92.
Gary W Small; Prabha Siddarth; Daniel H S Silverman; Linda M Ercoli; Karen J Miller; Helen Lavretsky; Susan Y Bookheimer; S-C Huang; Jorge R Barrio; Michael E PhelpsThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2008;16(12):999-1009.
This section shows information that has been computed by using the fingerprint of the grant, including related publications, related experts and related grants - all with fingerprints representing significant amounts of overlap between their fingerprint and this grant. The red dots indicate whether those experts or terms actually appear within this grant, showing potential and actual connections.
1 September 1998 - 31 July 2008
NATIONAL INSTITUTE ON AGING
Total Funding: $ 18,974,144
Dekosky, Steven T
30 September 1999 - 31 July 2010
NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE
Total Funding: $ 30,761,491
SMALL, GARY W
1 March 1983 - 29 February 1988
NATIONAL INSTITUTE ON AGING
Total Funding: $ 270,498
D B Howieson; R Camicioli; J Quinn; L C Silbert; B Care; M M Moore; A Dame; G Sexton; J A KayeNeurology 2003;60(9):1489-94.
L Mosconi; D Perani; S Sorbi; K Herholz; B Nacmias; V Holthoff; E Salmon; J-C Baron; M T R De Cristofaro; A Padovani; et al.Neurology 2004;63(12):2332-40.
George Bartzokis; Po H Lu; Daniel H Geschwind; Nancy Edwards; Jim Mintz; Jeffrey L CummingsArchives of general psychiatry 2006;63(1):63-72.
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