The grant detail shows the name of the PI, active dates of the project, the funding institute and the abstract of the grant. This abstract is what is used to create the fingerprint of the grant. If any publications referencing this grant are found in the data, they will be listed here as well.
Genome Wide associate analysis of Alzheimer's Disease
30 September 2009 - 31 August 2011
NATIONAL INSTITUTE ON AGING
Total Funding: $ 5,401,791
[unreadable] Genome-wide association (GWA) methods have now been successfully used to detect disease-related susceptibility genes numerous genetically complex disorders. In these studies, a critical element for success is that the sample size be large enough so that there is adequate power to detect genes with small effect sizes at a genome-wide significance level. As an example, type 2 diabetes, susceptibility genes with odds ratios of ~1.3 were detected with cohorts of ~15,000 cases and a comparable number of controls. For AD, preliminary GWA studies utilized samples of 1,000 cases or less have been performed. These studies have the power to detect modest effect loci but not the small effect genes typically found in the analysis of other complex disorders. The primary goals of this application are to: 1) Assemble enough AD cases and comparable elderly normal controls to detect small effect loci;2) Perform GWA studies using a high- density genotyping platform to detect small effect loci that contribute to AD susceptibility;3) Analyze a large familial AD collection using the same genotyping platform so that family-based methods can be applied to AD gene discovery;4) Provide a DNA, phenotype, and genotype resource of well- characterized AD cases, mild cognitive impaired (MCI) subjects, and controls for the genetics community to analyze. The cases, MCI subjects, and controls will be the approximately 16,500 subjects currently being studied by the 29 NIA-funded Alzheimer's Disease Centers (ADC's). Extensive phenotype data as a Uniform Data Set (UDS) for these subjects is in a centralized database (National Alzheimer Coordinating Center or NACC). DNA from these subjects will be deposited in the National Cell Repository for Alzheimer's Disease (NCRAD), an existing repository. A second cohort will be multiplex families with extensive phenotype data and DNA currently available from the NIMH Genetics Initiative repository. This study will make use of the infrastructure of the existing Alzheimer's Disease Genetics Consortium (ADGC) to coordinate that data from multiple GWA studies for subsequent meta and combined analysis of multiple AD GWA studies, and to provide investigators with AD GWA data for subsequent analysis. [unreadable] [unreadable] PUBLIC HEALTH RELEVANCE: Alzheimer's disease affects over 5 million people in the US costing the Federal Government over $100 billion dollars/year. Because our population is aging, in 2050, if the disease remains untreatable, there will be 16 million people in the US with AD costing $1 trillion dollars/year. Presently there are no methods of preventing AD or halting progression. Thus, more fundamental knowledge on disease mechanism is needed. [unreadable] [unreadable] [unreadable] [unreadable]
9 Resulting Publications
Martin A Kohli; Krista John-Williams; Ruchita Rajbhandary; Adam Naj; Patrice Whitehead; Kara Hamilton; Regina M Carney; Clinton Wright; Elizabeth Crocco; Harry E Gwirtzman; et al.Neurobiology of aging 2013;34(5):1519.e5-12.
Patrick Holton; Mina Ryten; Michael Nalls; Daniah Trabzuni; Michael E Weale; Dena Hernandez; Helen Crehan; J Raphael Gibbs; Richard Mayeux; Jonathan L Haines; et al.Annals of human genetics 2013;77(2):85-105.
Gyungah Jun; Badri N Vardarajan; Jacqueline Buros; Chang-En Yu; Michele V Hawk; Beth A Dombroski; Paul K Crane; Eric B Larson; ; Richard Mayeux; et al.Archives of neurology 2012;69(10):1270-9.
Gerard D Schellenberg; Thomas J MontineActa neuropathologica 2012;124(3):305-23.
Fanggeng Zou; High Seng Chai; Curtis S Younkin; Mariet Allen; Julia Crook; V Shane Pankratz; Minerva M Carrasquillo; Christopher N Rowley; Asha A Nair; Sumit Middha; et al.PLoS genetics 2012;8(6):e1002707.
Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; et al.Nature genetics 2011;43(5):436-41.
Gyungah Jun; Adam C Naj; Gary W Beecham; Li-San Wang; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Nilufer Ertekin-Taner; M Daniele Fallin; Robert Friedland; et al.Archives of neurology 2010;67(12):1473-84.
D M Kay; C F Stevens; T H Hamza; J S Montimurro; C P Zabetian; S A Factor; A Samii; A Griffith; J W Roberts; E S Molho; et al.Neurology 2010;75(13):1189-94.
Mi-Ryung Han; Gerard D Schellenberg; Li-San Wang;BMC neurology 2010;10():90.
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TANZI, RUDOLPH EMILE
1 May 1999 - 30 April 2018
NATIONAL INSTITUTE OF MENTAL HEALTH
Total Funding: $ 3,474,948
PERICAK-VANCE, MARGARET A.
1 April 2008 - 31 March 2013
NATIONAL INSTITUTE ON AGING
Total Funding: $ 5,843,348
Mayeux, Richard P
1 December 1998 - 31 January 2004
NATIONAL INSTITUTE ON AGING
Total Funding: $ 5,549,515
Lars Bertram; Christina M Lill; Rudolph E TanziNeuron 2010;68(2):270-81.
Rita J Guerreiro; John HardyBiochemical Society transactions 2011;39(4):910-6.
Lars Bertram; Rudolph E TanziProgress in molecular biology and translational science 2012;107():79-100.
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