Seubert, Peter

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a-synuclein clearance strategies for the treatment of Lewy body disease.

1 July 2000 - 30 June 2016
NATIONAL INSTITUTE ON AGING
Total Funding: $ 1,499,422

148 Resulting Publications

• 1.

  2013

  Meaghan Morris; Patricia Hamto; Anthony Adame; Nino Devidze; Eliezer Masliah; Lennart Mucke

  Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice.

  Neurobiology of aging 2013;34(6):1523-9.

• 2.

  2013

  Elvira Valera; Eliezer Masliah

  Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies.

  Pharmacology & therapeutics 2013;138(3):311-22.

• 3.

  2013

  Gilyana G Borlikova; Margarita Trejo; Alexandra J Mably; Jessica M Mc Donald; Carlo Sala Frigerio; Ciaran M Regan; Keith J Murphy; Eliezer Masliah; Dominic M Walsh

  Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation.

  Neurobiology of aging 2013;34(5):1315-27.

• 4.

  2013

  Abdullah Sherzai; Steven D Edland; Eliezer Masliah; Lawrence Hansen; Donald P Pizzo; Ayesha Sherzai; Jody Corey-Bloom

  Spongiform change in dementia with lewy bodies and Alzheimer disease.

  Alzheimer disease and associated disorders 2013;27(2):157-61.

• 5.

  2013

  Dora Games; Peter Seubert; Edward Rockenstein; Christina Patrick; Margarita Trejo; Kiren Ubhi; Benjamin Ettle; Majid Ghassemiam; Robin Barbour; Dale Schenk; et al.

  Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein.

  The American journal of pathology 2013;182(3):940-53.

• 6.

  2013

  Stephanie S Dusaban; Nicole H Purcell; Edward Rockenstein; Eliezer Masliah; Min Kyung Cho; Alan V Smrcka; Joan Heller Brown

  Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses.

  Proceedings of the National Academy of Sciences of the United States of America 2013;110(9):3609-14.

• 7.

  2013

  Daniela Boassa; Monica L Berlanga; Mary Ann Yang; Masako Terada; Junru Hu; Eric A Bushong; Minju Hwang; Eliezer Masliah; Julia M George; Mark H Ellisman

  Mapping the subcellular distribution of α-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(6):2605-15.

• 8.

  2013

  Kiren Ubhi; Edward Rockenstein; Ruben Vazquez-Roque; Michael Mante; Chandra Inglis; Christina Patrick; Anthony Adame; Margaret Fahnestock; Edith Doppler; Philip Novak; et al.

  Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease.

  Journal of neuroscience research 2013;91(2):167-77.

• 9.

  2013

  Timothy Y Huang; Sarah Michael; Tao Xu; Ali Sarkeshik; James J Moresco; John R Yates; Eliezer Masliah; Gary M Bokoch; Céline DerMardirossian

  A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation.

  Molecular biology of the cell 2013;24(3):194-209.

• 10.

  2013

  Silke Nuber; Florian Harmuth; Zacharias Kohl; Anthony Adame; Margaritha Trejo; Kai Schönig; Frank Zimmermann; Claudia Bauer; Nicolas Casadei; Christiane Giel; et al.

  A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats.

  Brain : a journal of neurology 2013;136(Pt 2):412-32.

• 11.

  2013

  Brian Spencer; Sarah Michael; Jay Shen; Kori Kosberg; Edward Rockenstein; Christina Patrick; Anthony Adame; Eliezer Masliah

  Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD.

  Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(1):31-41.

• 12.

  2013

  Kiren Ubhi; Eliezer Masliah

  Alzheimer's disease: recent advances and future perspectives.

  Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S185-94.

• 13.

  2013

  Hilal A Lashuel; Cassia R Overk; Abid Oueslati; Eliezer Masliah

  The many faces of α-synuclein: from structure and toxicity to therapeutic target.

  Nature reviews. Neuroscience 2013;14(1):38-48.

• 14.

  2013

  David Amschl; Jörg Neddens; Daniel Havas; Stefanie Flunkert; Roland Rabl; Heinrich Römer; Edward Rockenstein; Eliezer Masliah; Manfred Windisch; Birgit Hutter-Paier

  Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model.

  BMC neuroscience 2013;14():6.

• 15.

  2013

  Changyoun Kim; Dong-Hwan Ho; Ji-Eun Suk; Sungyong You; Sarah Michael; Junghee Kang; Sung Joong Lee; Eliezer Masliah; Daehee Hwang; He-Jin Lee; et al.

  Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia.

  Nature communications 2013;4():1562.

• 16.

  2012

  Beate Winner; Martin Regensburger; Sebastian Schreglmann; Leah Boyer; Iryna Prots; Edward Rockenstein; Michael Mante; Chunmei Zhao; Jürgen Winkler; Eliezer Masliah; et al.

  Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(47):16906-16.

• 17.

  2012

  Debby Tsuang; James B Leverenz; Oscar L Lopez; Ronald L Hamilton; David A Bennett; Julie A Schneider; Aron S Buchman; Eric B Larson; Paul K Crane; Jeffrey A Kaye; et al.

  GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.

  Neurology 2012;79(19):1944-50.

• 18.

  2012

  Han Zhang; Yun-wu Zhang; Yaomin Chen; Xiumei Huang; Fangfang Zhou; Weiwei Wang; Bo Xian; Xian Zhang; Eliezer Masliah; Quan Chen; et al.

  Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(44):15565-76.

• 19.

  2012

  Melanie B Watson; Franziska Richter; Soo Kyung Lee; Lauryn Gabby; Jennifer Wu; Eliezer Masliah; Rita B Effros; Marie-Françoise Chesselet

  Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein.

  Experimental neurology 2012;237(2):318-34.

• 20.

  2012

  Eun-Jin Bae; He-Jin Lee; Edward Rockenstein; Dong-Hwan Ho; Eun-Bi Park; Na-Young Yang; Paula Desplats; Eliezer Masliah; Seung-Jae Lee

  Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(39):13454-69.

• 21.

  2012

  Paula Desplats; Brian Spencer; Leslie Crews; Pruthul Pathel; Dinorah Morvinski-Friedmann; Kori Kosberg; Scott Roberts; Christina Patrick; Beate Winner; Juergen Winkler; et al.

  α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1.

  The Journal of biological chemistry 2012;287(38):31691-702.

• 22.

  2012

  David Vilchez; Leah Boyer; Ianessa Morantte; Margaret Lutz; Carsten Merkwirth; Derek Joyce; Brian Spencer; Lesley Page; Eliezer Masliah; W Travis Berggren; et al.

  Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.

  Nature 2012;489(7415):304-8.

• 23.

  2012

  Owen M Siggs; Justin T Cruite; Xin Du; Sophie Rutschmann; Eliezer Masliah; Bruce Beutler; Michael B A Oldstone

  Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease.

  Proceedings of the National Academy of Sciences of the United States of America 2012;109(34):13733-8.

• 24.

  2012

  Yaomin Chen; Xiumei Huang; Yun-wu Zhang; Edward Rockenstein; Guojun Bu; Todd E Golde; Eliezer Masliah; Huaxi Xu

  Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(33):11390-5.

• 25.

  2012

  Young-Don Kwak; Bin Wang; Jing Jing Li; Ruishan Wang; Qiyue Deng; Shiyong Diao; Yaomin Chen; Raymond Xu; Eliezer Masliah; Huaxi Xu; et al.

  Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(32):10971-81.

• 26.

  2012

  Lidia Reznichenko; Qun Cheng; Krystal Nizar; Sergey L Gratiy; Payam A Saisan; Edward M Rockenstein; Tanya González; Christina Patrick; Brian Spencer; Paula Desplats; et al.

  In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(29):9992-8.

• 27.

  2012

  Bin Tang; Kristina Becanovic; Paula A Desplats; Brian Spencer; Austin M Hill; Colum Connolly; Eliezer Masliah; Blair R Leavitt; Elizabeth A Thomas

  Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease.

  Human molecular genetics 2012;21(14):3097-111.

• 28.

  2012

  Taiji Tsunemi; Travis D Ashe; Bradley E Morrison; Kathryn R Soriano; Jonathan Au; Ruben A Vázquez Roque; Eduardo R Lazarowski; Vincent A Damian; Eliezer Masliah; Albert R La Spada

  PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

  Science translational medicine 2012;4(142):142ra97.

• 29.

  2012

  Vicente Sancenon; Sue-Ann Lee; Christina Patrick; Janice Griffith; Amy Paulino; Tiago F Outeiro; Fulvio Reggiori; Eliezer Masliah; Paul J Muchowski

  Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.

  Human molecular genetics 2012;21(11):2432-49.

• 30.

  2012

  Bruno Fauvet; Martial K Mbefo; Mohamed-Bilal Fares; Carole Desobry; Sarah Michael; Mustafa T Ardah; Elpida Tsika; Philippe Coune; Michel Prudent; Niels Lion; et al.

  α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

  The Journal of biological chemistry 2012;287(19):15345-64.

• 31.

  2012

  Jochen Klucken; Anne-Maria Poehler; Darius Ebrahimi-Fakhari; Jacqueline Schneider; Silke Nuber; Edward Rockenstein; Ursula Schlötzer-Schrehardt; Bradley T Hyman; Pamela J McLean; Eliezer Masliah; et al.

  Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.

  Autophagy 2012;8(5):754-66.

• 32.

  2012

  Laure Verret; Edward O Mann; Giao B Hang; Albert M I Barth; Inma Cobos; Kaitlyn Ho; Nino Devidze; Eliezer Masliah; Anatol C Kreitzer; Istvan Mody; et al.

  Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.

  Cell 2012;149(3):708-21.

• 33.

  2012

  Kiren Ubhi; Chandra Inglis; Michael Mante; Christina Patrick; Anthony Adame; Brian Spencer; Edward Rockenstein; Verena May; Juergen Winkler; Eliezer Masliah

  Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy.

  Experimental neurology 2012;234(2):405-16.

• 34.

  2012

  Eliezer Masliah; Edward Rockenstein; Chandra Inglis; Anthony Adame; Cyrus Bett; Melanie Lucero; Christina J Sigurdson

  Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice.

  Prion 2012;6(2):184-90.

• 35.

  2012

  Edward Rockenstein; Kiren Ubhi; Chandra Inglis; Michael Mante; Christina Patrick; Anthony Adame; Eliezer Masliah

  Neuronal to oligodendroglial α-synuclein redistribution in a double transgenic model of multiple system atrophy.

  Neuroreport 2012;23(4):259-64.

• 36.

  2012

  Igor F Tsigelny; Yuriy Sharikov; Wolfgang Wrasidlo; Tania Gonzalez; Paula A Desplats; Leslie Crews; Brian Spencer; Eliezer Masliah

  Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.

  The FEBS journal 2012;279(6):1000-13.

• 37.

  2012

  Iddo Magen; Sheila M Fleming; Chunni Zhu; Eddie C Garcia; Katherine M Cardiff; Diana Dinh; Krystal De La Rosa; Maria Sanchez; Eileen Ruth Torres; Eliezer Masliah; et al.

  Cognitive deficits in a mouse model of pre-manifest Parkinson's disease.

  The European journal of neuroscience 2012;35(6):870-82.

• 38.

  2012

  Cyrus Bett; Shivanjali Joshi-Barr; Melanie Lucero; Margarita Trejo; Pawel Liberski; Jeffery W Kelly; Eliezer Masliah; Christina J Sigurdson

  Biochemical properties of highly neuroinvasive prion strains.

  PLoS pathogens 2012;8(2):e1002522.

• 39.

  2012

  Rubén Antonio Vázquez-Roque; Brenda Ramos; Carolina Tecuatl; Ismael Juárez; Anthony Adame; Fidel de la Cruz; Sergio Zamudio; Raúl Mena; Edward Rockenstein; Eliezer Masliah; et al.

  Chronic administration of the neurotrophic agent cerebrolysin ameliorates the behavioral and morphological changes induced by neonatal ventral hippocampus lesion in a rat model of schizophrenia.

  Journal of neuroscience research 2012;90(1):288-306.

• 40.

  2012

  Markus Mandler; Edward Rockenstein; Kiren Ubhi; Lawrence Hansen; Anthony Adame; Sarah Michael; Douglas Galasko; Radmila Santic; Frank Mattner; Eliezer Masliah

  Detection of peri-synaptic amyloid-β pyroglutamate aggregates in early stages of Alzheimer's disease and in AβPP transgenic mice using a novel monoclonal antibody.

  Journal of Alzheimer's disease : JAD 2012;28(4):783-94.

• 41.

  2012

  Bradley T Hyman; Creighton H Phelps; Thomas G Beach; Eileen H Bigio; Nigel J Cairns; Maria C Carrillo; Dennis W Dickson; Charles Duyckaerts; Matthew P Frosch; Eliezer Masliah; et al.

  National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease.

  Alzheimer's & dementia : the journal of the Alzheimer's Association 2012;8(1):1-13.

• 42.

  2012

  Anna E Cartier; Kiren Ubhi; Brian Spencer; Ruben A Vazquez-Roque; Kori Ann Kosberg; Lawrence Fourgeaud; Priya Kanayson; Christina Patrick; Edward Rockenstein; Gentry N Patrick; et al.

  Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.

  PloS one 2012;7(4):e34713.

• 43.

  2012

  Seung-Jae Lee; Paula Desplats; He-Jin Lee; Brian Spencer; Eliezer Masliah

  Cell-to-cell transmission of α-synuclein aggregates.

  Methods in molecular biology (Clifton, N.J.) 2012;849():347-59.

• 44.

  2012

  Markus Britschgi; Yoshiko Takeda-Uchimura; Edward Rockenstein; Hudson Johns; Eliezer Masliah; Tony Wyss-Coray

  Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.

  Journal of neuroinflammation 2012;9():220.

• 45.

  2012

  Akio Sekigawa; Masayo Fujita; Kazunari Sekiyama; Yoshiki Takamatsu; Taku Hatano; Edward Rockenstein; Albert R La Spada; Eliezer Masliah; Makoto Hashimoto

  Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein.

  Molecular brain 2012;5():34.

• 46.

  2012

  Paula Desplats; Pruthul Patel; Kori Kosberg; Michael Mante; Christina Patrick; Edward Rockenstein; Masayo Fujita; Makoto Hashimoto; Eliezer Masliah

  Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.

  Molecular neurodegeneration 2012;7():49.

• 47.

  2012

  Julie A Harris; Akihiko Koyama; Sumihiro Maeda; Kaitlyn Ho; Nino Devidze; Dena B Dubal; Gui-Qiu Yu; Eliezer Masliah; Lennart Mucke

  Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.

  PloS one 2012;7(9):e45881.

• 48.

  2011

  Edward Rockenstein; Kiren Ubhi; Emiley Pham; Sarah Michael; Edith Doppler; Philipp Novak; Chandra Inglis; Michael Mante; Anthony Adame; X Anton Alvarez; et al.

  Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease.

  Journal of neuroscience research 2011;89(11):1812-21.

• 49.

  2011

  Kiren Ubhi; Phillip Low; Eliezer Masliah

  Multiple system atrophy: a clinical and neuropathological perspective.

  Trends in neurosciences 2011;34(11):581-90.

• 50.

  2011

  Xinyi Li; Eliezer Masliah; Natàlia Reixach; Joel N Buxbaum

  Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(35):12483-90.

• 51.

  2011

  Kiren Ubhi; Eliezer Masliah

  Recent advances in the development of immunotherapies for tauopathies.

  Experimental neurology 2011;230(2):157-61.

• 52.

  2011

  Nadia Stefanova; Lisa Fellner; Markus Reindl; Eliezer Masliah; Werner Poewe; Gregor K Wenning

  Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons.

  The American journal of pathology 2011;179(2):954-63.

• 53.

  2011

  Troy T Rohn; Ellen Wirawan; Raquel J Brown; Jordan R Harris; Eliezer Masliah; Peter Vandenabeele

  Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain.

  Neurobiology of disease 2011;43(1):68-78.

• 54.

  2011

  Ken Nakamura; Venu M Nemani; Farnaz Azarbal; Gaia Skibinski; Jon M Levy; Kiyoshi Egami; Larissa Munishkina; Jue Zhang; Brooke Gardner; Junko Wakabayashi; et al.

  Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein.

  The Journal of biological chemistry 2011;286(23):20710-26.

• 55.

  2011

  Alice S Chen-Plotkin; Maria Martinez-Lage; Patrick M A Sleiman; William Hu; Robert Greene; Elisabeth McCarty Wood; Shaoxu Bing; Murray Grossman; Gerard D Schellenberg; Kimmo J Hatanpaa; et al.

  Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.

  Archives of neurology 2011;68(4):488-97.

• 56.

  2011

  Paula Desplats; Brian Spencer; Elizabeth Coffee; Pruthul Patel; Sarah Michael; Christina Patrick; Anthony Adame; Edward Rockenstein; Eliezer Masliah

  Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases.

  The Journal of biological chemistry 2011;286(11):9031-7.

• 57.

  2011

  Brian Spencer; Robert A Marr; Ryan Gindi; Rewati Potkar; Sarah Michael; Anthony Adame; Edward Rockenstein; Inder M Verma; Eliezer Masliah

  Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease.

  PloS one 2011;6(1):e16575.

• 58.

  2011

  L Crews; C Patrick; A Adame; E Rockenstein; E Masliah

  Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease.

  Cell death & disease 2011;2():e120.

• 59.

  2011

  Daniel Havas; Birgit Hutter-Paier; Kiren Ubhi; Edward Rockenstein; Karl Crailsheim; Eliezer Masliah; Manfred Windisch

  A longitudinal study of behavioral deficits in an AβPP transgenic mouse model of Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 2011;25(2):231-43.

• 60.

  2010

  Seung-Jae Lee; Paula Desplats; Christina Sigurdson; Igor Tsigelny; Eliezer Masliah

  Cell-to-cell transmission of non-prion protein aggregates.

  Nature reviews. Neurology 2010;6(12):702-6.

• 61.

  2010

  Kiren Ubhi; Kevin Peng; Stephanie Lessig; Jennilyn Estrella; Anthony Adame; Douglas Galasko; David P Salmon; Lawrence A Hansen; Claudia H Kawas; Eliezer Masliah

  Neuropathology of dementia with Lewy bodies in advanced age: a comparison with Alzheimer disease.

  Neuroscience letters 2010;485(3):222-7.

• 62.

  2010

  Faviola Alcantara-Gonzalez; Ismael Juarez; Oscar Solis; Isaura Martinez-Tellez; Israel Camacho-Abrego; Eliezer Masliah; Raul Mena; Gonzalo Flores

  Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus, and nucleus accumbens in old rats after chronic donepezil administration.

  Synapse (New York, N.Y.) 2010;64(10):786-93.

• 63.

  2010

  Nicole M Lewandowski; Shulin Ju; Miguel Verbitsky; Barbara Ross; Melissa L Geddie; Edward Rockenstein; Anthony Adame; Alim Muhammad; Jean Paul Vonsattel; Dagmar Ringe; et al.

  Polyamine pathway contributes to the pathogenesis of Parkinson disease.

  Proceedings of the National Academy of Sciences of the United States of America 2010;107(39):16970-5.

• 64.

  2010

  Leslie Crews; Anthony Adame; Christina Patrick; Alexandra Delaney; Emiley Pham; Edward Rockenstein; Lawrence Hansen; Eliezer Masliah

  Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(37):12252-62.

• 65.

  2010

  E Masliah; F Xie; S Dayan; E Rockenstein; M Mante; A Adame; C M Patrick; A F Chan; B Zheng

  Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice.

  Neuroscience 2010;169(1):488-94.

• 66.

  2010

  Stephanie Lessig; Kiren Ubhi; Douglas Galasko; Anthony Adame; Emiley Pham; Kelly Remidios; Michael Chang; Lawrence A Hansen; Eliezer Masliah

  Reduced hypocretin (orexin) levels in dementia with Lewy bodies.

  Neuroreport 2010;21(11):756-60.

• 67.

  2010

  Jason Miller; Montserrat Arrasate; Benjamin A Shaby; Siddhartha Mitra; Eliezer Masliah; Steven Finkbeiner

  Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(31):10541-50.

• 68.

  2010

  Emiley Pham; Leslie Crews; Kiren Ubhi; Lawrence Hansen; Anthony Adame; Anna Cartier; David Salmon; Douglas Galasko; Sarah Michael; Jeffrey N Savas; et al.

  Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins.

  The FEBS journal 2010;277(14):3051-67.

• 69.

  2010

  Corinne G Jolivalt; Rosemarie Hurford; Corinne A Lee; Wilmar Dumaop; Edward Rockenstein; Eliezer Masliah

  Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice.

  Experimental neurology 2010;223(2):422-31.

• 70.

  2010

  Kiren Ubhi; Edward Rockenstein; Michael Mante; Chandra Inglis; Anthony Adame; Christina Patrick; Kristen Whitney; Eliezer Masliah

  Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(18):6236-46.

• 71.

  2010

  Kiren Ubhi; Edward Rockenstein; Michael Mante; Chandra Inglis; Anthony Adame; Christina Patrick; Eliezer Masliah

  Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy.

  Neuroreport 2010;21(6):457-62.

• 72.

  2010

  Leslie Crews; Eliezer Masliah

  Molecular mechanisms of neurodegeneration in Alzheimer's disease.

  Human molecular genetics 2010;19(R1):R12-20.

• 73.

  2010

  He-Jin Lee; Ji-Eun Suk; Christina Patrick; Eun-Jin Bae; Ji-Hoon Cho; Sangchul Rho; Daehee Hwang; Eliezer Masliah; Seung-Jae Lee

  Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies.

  The Journal of biological chemistry 2010;285(12):9262-72.

• 74.

  2010

  Katerina E Paleologou; Abid Oueslati; Gideon Shakked; Carla C Rospigliosi; Hai-Young Kim; Gonzalo R Lamberto; Claudio O Fernandez; Adrian Schmid; Fariba Chegini; Wei Ping Gai; et al.

  Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(9):3184-98.

• 75.

  2010

  Leslie Crews; Edward Rockenstein; Eliezer Masliah

  APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis.

  Brain structure & function 2010;214(2-3):111-26.

• 76.

  2010

  Vivianna M Van Deerlin; Patrick M A Sleiman; Maria Martinez-Lage; Alice Chen-Plotkin; Li-San Wang; Neill R Graff-Radford; Dennis W Dickson; Rosa Rademakers; Bradley F Boeve; Murray Grossman; et al.

  Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

  Nature genetics 2010;42(3):234-9.

• 77.

  2010

  Andrew O Koob; Kiren Ubhi; Johan F Paulsson; Jeffery Kelly; Edward Rockenstein; Michael Mante; Anthony Adame; Eliezer Masliah

  Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies.

  Experimental neurology 2010;221(2):267-74.

• 78.

  2010

  Cynthia A Lemere; Eliezer Masliah

  Can Alzheimer disease be prevented by amyloid-beta immunotherapy?

  Nature reviews. Neurology 2010;6(2):108-19.

• 79.

  2010

  Andrew O Koob; Amy D Paulino; Eliezer Masliah

  GFAP reactivity, apolipoprotein E redistribution and cholesterol reduction in human astrocytes treated with alpha-synuclein.

  Neuroscience letters 2010;469(1):11-4.

• 80.

  2010

  Leslie Crews; Brian Spencer; Paula Desplats; Christina Patrick; Amy Paulino; Edward Rockenstein; Lawrence Hansen; Anthony Adame; Douglas Galasko; Eliezer Masliah

  Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.

  PloS one 2010;5(2):e9313.

• 81.

  2010

  Vivek K Unni; Tamily A Weissman; Edward Rockenstein; Eliezer Masliah; Pamela J McLean; Bradley T Hyman

  In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility.

  PloS one 2010;5(5):e10589.

• 82.

  2010

  Philipp A Jaeger; Fiona Pickford; Chung-Huan Sun; Kurt M Lucin; Eliezer Masliah; Tony Wyss-Coray

  Regulation of amyloid precursor protein processing by the Beclin 1 complex.

  PloS one 2010;5(6):e11102.

• 83.

  2009

  Ganesh M Shankar; Malcolm A Leissring; Anthony Adame; Xiaoyan Sun; Edward Spooner; Eliezer Masliah; Dennis J Selkoe; Cynthia A Lemere; Dominic M Walsh

  Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.

  Neurobiology of disease 2009;36(2):293-302.

• 84.

  2009

  Brian Spencer; Rewati Potkar; Margarita Trejo; Edward Rockenstein; Christina Patrick; Ryan Gindi; Anthony Adame; Tony Wyss-Coray; Eliezer Masliah

  Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(43):13578-88.

• 85.

  2009

  Leslie Crews; Igor Tsigelny; Makoto Hashimoto; Eliezer Masliah

  Role of synucleins in Alzheimer's disease.

  Neurotoxicity research 2009;16(3):306-17.

• 86.

  2009

  Kiren Ubhi; Phil Hyu Lee; Anthony Adame; Chandra Inglis; Michael Mante; Edward Rockenstein; Nadia Stefanova; Gregor K Wenning; Eliezer Masliah

  Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy.

  Journal of neuroscience research 2009;87(12):2728-39.

• 87.

  2009

  Paula Desplats; He-Jin Lee; Eun-Jin Bae; Christina Patrick; Edward Rockenstein; Leslie Crews; Brian Spencer; Eliezer Masliah; Seung-Jae Lee

  Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.

  Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):13010-5.

• 88.

  2009

  Anna E Cartier; Stevan N Djakovic; Afshin Salehi; Scott M Wilson; Eliezer Masliah; Gentry N Patrick

  Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(24):7857-68.

• 89.

  2009

  Gideon M Shaked; Stephanie Chauv; Kiren Ubhi; Lawrence A Hansen; Eliezer Masliah

  Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid beta toxicity in Alzheimer's disease.

  The FEBS journal 2009;276(10):2736-51.

• 90.

  2009

  Roberta Marongiu; Brian Spencer; Leslie Crews; Anthony Adame; Christina Patrick; Margarita Trejo; Bruno Dallapiccola; Enza Maria Valente; Eliezer Masliah

  Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux.

  Journal of neurochemistry 2009;108(6):1561-74.

• 91.

  2009

  Alan H Nagahara; David A Merrill; Giovanni Coppola; Shingo Tsukada; Brock E Schroeder; Gideon M Shaked; Ling Wang; Armin Blesch; Albert Kim; James M Conner; et al.

  Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease.

  Nature medicine 2009;15(3):331-7.

• 92.

  2009

  John B Rose; Leslie Crews; Edward Rockenstein; Anthony Adame; Michael Mante; Louis B Hersh; Fred H Gage; Brian Spencer; Rewati Potkar; Robert A Marr; et al.

  Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(4):1115-25.

• 93.

  2008

  Igor F Tsigelny; Yuriy Sharikov; Mark A Miller; Eliezer Masliah

  Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies.

  Nanomedicine : nanotechnology, biology, and medicine 2008;4(4):350-7.

• 94.

  2008

  Edith Doppler; Edward Rockenstein; Kiren Ubhi; Chandra Inglis; Michael Mante; Anthony Adame; Leslie Crews; Monika Hitzl; Herbert Moessler; Eliezer Masliah

  Neurotrophic effects of Cerebrolysin in the Mecp2(308/Y) transgenic model of Rett syndrome.

  Acta neuropathologica 2008;116(4):425-37.

• 95.

  2008

  Kiren Ubhi; Edward Rockenstein; Michael Mante; Christina Patrick; Anthony Adame; Monica Thukral; Clifford Shults; Eliezer Masliah

  Rifampicin reduces alpha-synuclein in a transgenic mouse model of multiple system atrophy.

  Neuroreport 2008;19(13):1271-6.

• 96.

  2008

  Beate Winner; Edward Rockenstein; D Chichung Lie; Robert Aigner; Michael Mante; Ulrich Bogdahn; Sebastien Couillard-Despres; Eliezer Masliah; Jürgen Winkler

  Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis.

  Neurobiology of aging 2008;29(6):913-25.

• 97.

  2008

  Pazit Bar-On; Leslie Crews; Andrew O Koob; Hideya Mizuno; Anthony Adame; Brian Spencer; Eliezer Masliah

  Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease.

  Journal of neurochemistry 2008;105(5):1656-67.

• 98.

  2008

  Fiona Pickford; Eliezer Masliah; Markus Britschgi; Kurt Lucin; Ramya Narasimhan; Philipp A Jaeger; Scott Small; Brian Spencer; Edward Rockenstein; Beth Levine; et al.

  The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.

  The Journal of clinical investigation 2008;118(6):2190-9.

• 99.

  2008

  Leslie Crews; Hideya Mizuno; Paula Desplats; Edward Rockenstein; Anthony Adame; Christina Patrick; Beate Winner; Juergen Winkler; Eliezer Masliah

  Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(16):4250-60.

• 100.

  2008

  Kohichi Kawahara; Makoto Hashimoto; Pazit Bar-On; Gilbert J Ho; Leslie Crews; Hideya Mizuno; Edward Rockenstein; Syed Z Imam; Eliezer Masliah

  alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease.

  The Journal of biological chemistry 2008;283(11):6979-87.

• 101.

  2008

  Joel N Buxbaum; Zhengyi Ye; Natàlia Reixach; Linsey Friske; Coree Levy; Pritam Das; Todd Golde; Eliezer Masliah; Amanda R Roberts; Tamas Bartfai

  Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity.

  Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2681-6.

• 102.

  2008

  Leslie Crews; Edward Rockenstein; Eliezer Masliah

  Biological transgenic mouse models of Alzheimer's disease.

  Handbook of clinical neurology 2008;89():291-301.

• 103.

  2008

  Igor F Tsigelny; Leslie Crews; Paula Desplats; Gideon M Shaked; Yuriy Sharikov; Hideya Mizuno; Brian Spencer; Edward Rockenstein; Margarita Trejo; Oleksandr Platoshyn; et al.

  Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.

  PloS one 2008;3(9):e3135.

• 104.

  2008

  Brian Spencer; Robert A Marr; Edward Rockenstein; Leslie Crews; Anthony Adame; Rewati Potkar; Christina Patrick; Fred H Gage; Inder M Verma; Eliezer Masliah

  Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice.

  BMC neuroscience 2008;9():109.

• 105.

  2007

  Brian Spencer; Edward Rockenstein; Leslie Crews; Robert Marr; Eliezer Masliah

  Novel strategies for Alzheimer's disease treatment.

  Expert opinion on biological therapy 2007;7(12):1853-67.

• 106.

  2007

  Edward Rockenstein; Leslie Crews; Eliezer Masliah

  Transgenic animal models of neurodegenerative diseases and their application to treatment development.

  Advanced drug delivery reviews 2007;59(11):1093-102.

• 107.

  2007

  Igor F Tsigelny; Pazit Bar-On; Yuriy Sharikov; Leslie Crews; Makoto Hashimoto; Mark A Miller; Steve H Keller; Oleksandr Platoshyn; Jason X-J Yuan; Eliezer Masliah

  Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein.

  The FEBS journal 2007;274(7):1862-77.

• 108.

  2007

  Edward Rockenstein; Magdalena Torrance; Anthony Adame; Michael Mante; Pazit Bar-on; John B Rose; Leslie Crews; Eliezer Masliah

  Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(8):1981-91.

• 109.

  2007

  Brian Spencer; Leslie Crews; Eliezer Masliah

  Climbing the scaffolds of Parkinson's disease pathogenesis.

  Neuron 2007;53(4):469-70.

• 110.

  2006

  S M Fleming; J Salcedo; C B Hutson; E Rockenstein; E Masliah; M S Levine; M-F Chesselet

  Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein.

  Neuroscience 2006;142(4):1245-53.

• 111.

  2006

  R Lyle Patton; Walter M Kalback; Chera L Esh; Tyler A Kokjohn; Gregory D Van Vickle; Dean C Luehrs; Yu-Min Kuo; John Lopez; Daniel Brune; Isidro Ferrer; et al.

  Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis.

  The American journal of pathology 2006;169(3):1048-63.

• 112.

  2006

  Pazit Bar-On; Edward Rockenstein; Anthony Adame; Gilbert Ho; Makoto Hashimoto; Eliezer Masliah

  Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy.

  Journal of neurochemistry 2006;98(4):1032-45.

• 113.

  2006

  Brian Webster; Lawrence Hansen; Anthony Adame; Leslie Crews; Magdalena Torrance; Leon Thal; Eliezer Masliah

  Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease.

  Journal of neuropathology and experimental neurology 2006;65(2):142-51.

• 114.

  2006

  Eliezer Masliah; Leslie Crews; Lawrence Hansen

  Synaptic remodeling during aging and in Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):91-9.

• 115.

  2005

  Clifford W Shults; Edward Rockenstein; Leslie Crews; Anthony Adame; Michael Mante; Gabriel Larrea; Makoto Hashimoto; David Song; Takeshi Iwatsubo; Kyoko Tsuboi; et al.

  Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10689-99.

• 116.

  2005

  Oded Singer; Robert A Marr; Edward Rockenstein; Leslie Crews; Nicole G Coufal; Fred H Gage; Inder M Verma; Eliezer Masliah

  Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.

  Nature neuroscience 2005;8(10):1343-9.

• 117.

  2005

  Nathalie L Chevallier; Salvador Soriano; David E Kang; Eliezer Masliah; Gloria Hu; Edward H Koo

  Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation.

  The American journal of pathology 2005;167(1):151-9.

• 118.

  2005

  Eliezer Masliah; Edward Rockenstein; Anthony Adame; Michael Alford; Leslie Crews; Makoto Hashimoto; Peter Seubert; Michael Lee; Jason Goldstein; Tamie Chilcote; et al.

  Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease.

  Neuron 2005;46(6):857-68.

• 119.

  2005

  Kyoko Tsuboi; John J Grzesiak; Michael Bouvet; Makoto Hashimoto; Eliezer Masliah; Clifford W Shults

  Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell death.

  Molecular and cellular neurosciences 2005;29(2):259-68.

• 120.

  2005

  Gilbert J Ho; Makoto Hashimoto; Anthony Adame; Matthew Izu; Michael F Alford; Leon J Thal; Lawrence A Hansen; Eliezer Masliah

  Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role.

  Neurobiology of aging 2005;26(5):625-35.

• 121.

  2005

  Edward Rockenstein; Gert Schwach; Elisabeth Ingolic; Anthony Adame; Leslie Crews; Michael Mante; Roswitha Pfragner; Edith Schreiner; Manfred Windisch; Eliezer Masliah

  Lysosomal pathology associated with alpha-synuclein accumulation in transgenic models using an eGFP fusion protein.

  Journal of neuroscience research 2005;80(2):247-59.

• 122.

  2005

  Gilbert J Ho; Roulla Drego; Edwin Hakimian; Eliezer Masliah

  Mechanisms of cell signaling and inflammation in Alzheimer's disease.

  Current drug targets. Inflammation and allergy 2005;4(2):247-56.

• 123.

  2005

  E Rockenstein; A Adame; M Mante; G Larrea; L Crews; M Windisch; H Moessler; E Masliah

  Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer's disease with the neurotrophic compound cerebrolysin.

  Journal of neural transmission (Vienna, Austria : 1996) 2005;112(2):269-82.

• 124.

  2005

  E Masliah; L Hansen; A Adame; L Crews; F Bard; C Lee; P Seubert; D Games; L Kirby; D Schenk

  Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease.

  Neurology 2005;64(1):129-31.

• 125.

  2004

  Jochen Klucken; Youngah Shin; Bradley T Hyman; Pamela J McLean

  A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.

  Biochemical and biophysical research communications 2004;325(1):367-73.

• 126.

  2004

  M Hashimoto; E Rockenstein; M Mante; L Crews; P Bar-On; F H Gage; R Marr; E Masliah

  An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model.

  Gene therapy 2004;11(23):1713-23.

• 127.

  2004

  Sheila M Fleming; Jonathan Salcedo; Pierre-Olivier Fernagut; Edward Rockenstein; Eliezer Masliah; Michael S Levine; Marie-Françoise Chesselet

  Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(42):9434-40.

• 128.

  2004

  Jochen Klucken; Youngah Shin; Eliezer Masliah; Bradley T Hyman; Pamela J McLean

  Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.

  The Journal of biological chemistry 2004;279(24):25497-502.

• 129.

  2004

  Makoto Hashimoto; Pazit Bar-On; Gilbert Ho; Takato Takenouchi; Edward Rockenstein; Leslie Crews; Eliezer Masliah

  Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease.

  The Journal of biological chemistry 2004;279(22):23622-9.

• 130.

  2004

  Robert A Marr; Hanjun Guan; Edward Rockenstein; Mark Kindy; Fred H Gage; Inder Verma; Eliezer Masliah; Louis B Hersh

  Neprilysin regulates amyloid Beta peptide levels.

  Journal of molecular neuroscience : MN 2004;22(1-2):5-11.

• 131.

  2004

  Makoto Hashimoto; Kohichi Kawahara; Pazit Bar-On; Edward Rockenstein; Leslie Crews; Eliezer Masliah

  The Role of alpha-synuclein assembly and metabolism in the pathogenesis of Lewy body disease.

  Journal of molecular neuroscience : MN 2004;24(3):343-52.

• 132.

  2003

  Thomas C Brionne; Ina Tesseur; Eliezer Masliah; Tony Wyss-Coray

  Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain.

  Neuron 2003;40(6):1133-45.

• 133.

  2003

  Dianne Langford; Eliezer Masliah

  The emerging role of infectious pathogens in neurodegenerative diseases.

  Experimental neurology 2003;184(2):553-5.

• 134.

  2003

  Makoto Hashimoto; Eliezer Masliah

  Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies.

  Neurochemical research 2003;28(11):1743-56.

• 135.

  2003

  Cristine Alves da Costa; Eliezer Masliah; Frédéric Checler

  Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease.

  The Journal of biological chemistry 2003;278(39):37330-5.

• 136.

  2003

  B P Kennedy; M G Ziegler; M Alford; L A Hansen; L J Thal; E Masliah

  Early and persistent alterations in prefrontal cortex MAO A and B in Alzheimer's disease.

  Journal of neural transmission (Vienna, Austria : 1996) 2003;110(7):789-801.

• 137.

  2003

  Makoto Hashimoto; Takato Takenouchi; Edward Rockenstein; Eliezer Masliah

  Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease.

  Journal of neurochemistry 2003;85(6):1468-79.

• 138.

  2003

  Makoto Hashimoto; Edward Rockenstein; Eliezer Masliah

  Transgenic models of alpha-synuclein pathology: past, present, and future.

  Annals of the New York Academy of Sciences 2003;991():171-88.

• 139.

  2003

  Robert A Marr; Edward Rockenstein; Atish Mukherjee; Mark S Kindy; Louis B Hersh; Fred H Gage; Inder M Verma; Eliezer Masliah

  Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):1992-6.

• 140.

  2003

  Makoto Hashimoto; Edward Rockenstein; Leslie Crews; Eliezer Masliah

  Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases.

  Neuromolecular medicine 2003;4(1-2):21-36.

• 141.

  2002

  Emily Van Uden; Margaret Mallory; Isaac Veinbergs; Michael Alford; Edward Rockenstein; Eliezer Masliah

  Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(21):9298-304.

• 142.

  2002

  Gilbert J Ho; Lawrence A Hansen; Michael F Alford; Katherine Foster; David P Salmon; Douglas Galasko; Leon J Thal; Eliezer Masliah

  Age at onset is associated with disease severity in Lewy body variant and Alzheimer's disease.

  Neuroreport 2002;13(14):1825-8.

• 143.

  2002

  Eliezer Masliah; Makoto Hashimoto

  Development of new treatments for Parkinson's disease in transgenic animal models: a role for beta-synuclein.

  Neurotoxicology 2002;23(4-5):461-8.

• 144.

  2002

  Edward Rockenstein; Margaret Mallory; Makoto Hashimoto; David Song; Clifford W Shults; Ingrid Lang; Eliezer Masliah

  Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters.

  Journal of neuroscience research 2002;68(5):568-78.

• 145.

  2002

  Makoto Hashimoto; Leigh J Hsu; Edward Rockenstein; Takato Takenouchi; Margaret Mallory; Eliezer Masliah

  alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells.

  The Journal of biological chemistry 2002;277(13):11465-72.

• 146.

  2001

  M Hashimoto; E Rockenstein; M Mante; M Mallory; E Masliah

  beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor.

  Neuron 2001;32(2):213-23.

• 147.

  2001

  E Masliah; E Rockenstein; I Veinbergs; Y Sagara; M Mallory; M Hashimoto; L Mucke

  beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.

  Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):12245-50.

• 148.

  2001

  E Rockenstein; L A Hansen; M Mallory; J Q Trojanowski; D Galasko; E Masliah

  Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease.

  Brain research 2001;914(1-2):48-56.

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