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GENETIC EPIDEMIOLOGY OF AGING IN A MULTIETHNIC COMMUNITY
30 September 2000 - 31 July 2003
NATIONAL INSTITUTE ON AGING
Total Funding: $ 2,268,838
(Abstract from application) For this exploratory proposal, we will develop the hypothesis that active survival into old age is highly dependent on the preservation of cognitive and physical function, and that the preservation of these functions is, in part, inherited. We will use longitudinal data from two cohorts of elderly African-Americans, Caribbean Hispanics and whites in northern Manhattan and their families to identify potential candidate phenotype definitions for genetic analysis. The phenotypes of interest will be related to the rate-of-change with age in cognitive and physical function, and to the age at which individuals reach critical stages in these functional domains. First, previously collected longitudinal data will be used to determine the rate-of-change with age in specific measures of cognitive performance and physical function, develop specific indicators of clinically meaningful changes corresponding to the loss of ability and determine the age-at-onset of these changes within strata defined by ethnic group, major disease categories, lifestyle factors and specific allelic polymorphisms. Interactions between genotypes and disease and lifestyle factors will be explored for their combined effects on the rate-of-change and the age-at-onset of specified changes in cognitive or physical function. Shared genetic effects on the phenotypic measures and years of total and active survival will be investigated in these individuals and their first-degree family members. In a recently established cohort we will recruit their same-sex siblings to analyze concordance in cognitive and physical function, concordance in rate-of-change in these functions based on retrospective interviews and familial aggregation of time-to-event measures in probands and first-degree relatives. We will collect and store DNA from examined siblings for future linkage or association studies, and we will assess the feasibility of repeated examinations in the siblings, in terms of participation and attrition rates, loss to follow-up, location of examinations, clinical procedures to be included, etc. We will use the experience in this multi-ethnic community to obtain information about phenotype definitions, study designs, sample size requirements, and analytic tools to detecting genes influencing the rate-of-change in cognitive and physical function.
10 Resulting Publications
Joshua Z Willey; Nikolaos Scarmeas; Frank A Provenzano; José A Luchsinger; Richard Mayeux; Adam M BrickmanJournal of neurology 2013;260(3):884-90.
Christiane Reitz; Christopher Conrad; Katherine Roszkowski; Robert S Rogers; Richard MayeuxArchives of neurology 2012;69(7):894-900.
Christiane Reitz; Rong Cheng; Nicole Schupf; Joseph H Lee; Pankaj D Mehta; Ekaterina Rogaeva; Peter St George-Hyslop; Richard MayeuxNeurobiology of aging 2012;33(1):199.e13-7.
Christiane Reitz; Rong Cheng; Ekaterina Rogaeva; Joseph H Lee; Shinya Tokuhiro; Fanggeng Zou; Karolien Bettens; Kristel Sleegers; Eng King Tan; Ryo Kimura; et al.Archives of neurology 2011;68(1):99-106.
Jennifer L Akerblom; Rosann Costa; Jose A Luchsinger; Jennifer J Manly; Ming-Xin Tang; Joseph H Lee; Richard Mayeux; Nicole SchupfAge and ageing 2008;37(2):207-13.
N Schupf; M-X Tang; S M Albert; R Costa; H Andrews; J H Lee; R MayeuxNeurology 2005;65(8):1218-26.
Nicole Schupf; Rosann Costa; Jose Luchsinger; Ming-Xin Tang; Joseph H Lee; Richard MayeuxJournal of the American Geriatrics Society 2005;53(2):219-26.
Nicole Schupf; Rosann Costa; Ming-Xin Tang; Howard Andrews; Benjamin Tycko; Joseph H Lee; Richard MayeuxNeurobiology of aging 2004;25(9):1231-40.
Joseph H Lee; Antonia Flaquer; Rosann Costa; Howard Andrews; Peter Cross; Rafael Lantigua; Nicole Schupf; Ming-Xin Tang; Richard MayeuxAmerican journal of medical genetics. Part A 2004;128A(2):159-64.
J H Lee; M X Tang; N Schupf; Y Stern; D M Jacobs; B Tycko; R MayeuxAmerican journal of medical genetics 2001;103(2):121-7.
This section shows information that has been computed by using the fingerprint of the grant, including related publications, related experts and related grants - all with fingerprints representing significant amounts of overlap between their fingerprint and this grant. The red dots indicate whether those experts or terms actually appear within this grant, showing potential and actual connections.
COLE, GREGORY M
1 September 2011 - 31 March 2016
NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE
Total Funding: $ 1,109,185
Mayeux, Richard P
1 December 1998 - 31 January 2004
NATIONAL INSTITUTE ON AGING
Total Funding: $ 5,549,515
KRAMER, JOEL H
15 June 2009 - 31 May 2014
NATIONAL INSTITUTE ON AGING
Total Funding: $ 1,979,400
J Tian; J Shi; K Bailey; J M Harris; A Pritchard; J-C Lambert; M-C Chartier-Harlin; S M Pickering-Brown; C L Lendon; D M A MannNeuroscience letters 2004;354(2):103-6.
E Masliah; W Samuel; I Veinbergs; M Mallory; M Mante; T SaitohBrain research 1997;751(2):307-14.
I Veinbergs; M Mallory; M Mante; E Rockenstein; J R Gilbert; E MasliahNeuroscience letters 1999;265(3):218-22.
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