The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia.
R G Cutler; N J Haughey; A Tammara; J C McArthur; A Nath; R Reid; D L Vargas; C A Pardo; M P Mattson (Profiled Author: Mattson, Mark P)
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, MD, USA.
BACKGROUND: Polymorphisms in apolipoprotein E have been associated with worse prognoses in numerous neurodegenerative conditions, including HIV dementia (HIVD). Despite these correlative observations, there has been little evidence suggesting a mechanism whereby the expression of ApoE4 renders neurons susceptible to insult. METHODS: Electrospray ionization tandem mass spectrometry was used to quantify levels of sphingolipids and sterols in brains of HIVD patients. Data were stratified according to APOE genotype. RESULTS: The authors found evidence of dysregulated lipid and sterol metabolism in HIVD patients with an APOE4 genotype. They also found elevations of sphingomyelin, ceramide, and cholesterol in the medial frontal cortex, parietal cortex, and cerebellum of HIVD patients with an APOE3/4 or APOE4/4 genotype compared with HIVD patients with an APOE3/3 genotype. There was no difference in the number of astrocytes or activated microglia in any brain region of the two patient populations, suggesting that modification of lipid metabolism in HIVD patients with an APOE4 genotype was not the result of increased CNS inflammation. CONCLUSIONS: HIV dementia patients with an APOE4 genotype may be sensitized to neural insults because of dysregulations in lipid metabolism.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
NATIONAL INSTITUTE ON AGING
Total Funding: $ 1,876,709
COLE, GREGORY M
1 September 2011 - 31 March 2016
NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE
Total Funding: $ 766,150
1 February 1989 - 30 June 2009
NATIONAL INSTITUTE ON AGING
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V V R Bandaru; J C McArthur; N Sacktor; R G Cutler; E L Knapp; M P Mattson; N J HaugheyNeurology 2007;68(18):1481-7.
Chava B Pocernich; Rukhsana Sultana; Eugene Hone; Jadwiga Turchan; Ralph N Martins; Vittorio Calabrese; Avindra Nath; D Allan ButterfieldJournal of neuroscience research 2004;77(4):532-9.
Norman J Haughey; Roy G Cutler; Anita Tamara; Justin C McArthur; Diana L Vargas; Carlos A Pardo; Jadwiga Turchan; Avindra Nath; Mark P MattsonAnnals of neurology 2004;55(2):257-67.
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