Mufson, Elliott J

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Neuropathologic correlates of apathy in Alzheimer's disease.

Gad A Marshall; Lynn A Fairbanks; Sibel Tekin; Harry V Vinters; Jeffrey L Cummings (Profiled Author: Cummings, Jeffrey L)

Department of Neurology, University of California at Los Angeles, Reed Neurological Research Center, 2-238, 710 Westwood Plaza, CA 90095-1769, USA. gmarshall@mednet.ucla.edu
Dementia and geriatric cognitive disorders 2006;21(3):144-7.

Apathy is the most commonly observed behavioral disturbance in Alzheimer's disease (AD) and has been suggested to be frontally mediated. Neuritic plaque (NP) and neurofibrillary tangle (NFT) counts were performed for 8 brain regions in 29 subjects with definite AD. Neuropsychiatric Inventory (NPI) for autopsied subjects was obtained from questioning of caregivers of subjects included in the study. Chronic apathy and total NPI composite scores correlated with anterior cingulate NFT counts (r = 0.518, p = 0.01, and r = 0.438, p = 0.032). This analysis suggests that chronic apathy in AD correlates with a greater anterior cingulate NFT burden and that chronic behavioral changes are more reflective than acute changes of disease pathology.

2 Originating Grant

• 1.

  CUMMINGS, JEFFREY L.

  UCLA Alzeheimer's Disease Research Center

  5 April 1999 - 31 March 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 19,865,071

• 2.

  TEPLOW, DAVID B

  UCLA Alzeheimer's Disease Research Center

  5 April 1999 - 31 March 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 1,913,591

Scientific Context

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