The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study.
Gerd Faxén Irving; Yvonne Freund-Levi; Maria Eriksdotter-Jönhagen; Hans Basun; Kerstin Brismar; Erik Hjorth; Jan Palmblad; Bengt Vessby; Inger Vedin; Lars-Olof Wahlund; et al. (Profiled Author: Wahlund, Lars-Olof)
Department of Neurobiology, Karolinska Institutet, Karolinska University, Hospital Huddinge, Stockholm, Sweden. firstname.lastname@example.org
Journal of the American Geriatrics Society 2009;57(1):11-7.
OBJECTIVES: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4). DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Specialist memory clinics in the Stockholm catchment area. PARTICIPANTS: Two hundred four patients (aged 73+/-9, 52% women) with mild to moderate AD. INTERVENTION: Patients with AD received 1.7 g of docosahexaenoic acid (DHA) and 0.6 g of eicosapentaenoic acid (EPA) (Omega-3/Omega-3 group; n=89, aged 73+/-9, 57% women) or placebo 0.6 g of linoleic acid per day (placebo/Omega-3 group; n=85, aged 73+/-9, 46% women) for 6 months. After 6 months, all patients received DHA and EPA for another 6 months. MEASUREMENTS: Anthropometry, biochemical nutritional and inflammatory markers, and appetite assessed by caregiver. RESULTS: Mean weight and body mass index (kg/m(2)) at baseline were 70.0+/-11.8 kg and 24.3+/-3.0 kg/m(2), respectively. At 6- and 12-month follow-up, weight had increased 0.7+/-2.5 kg (P=.02) and 1.4+/-2.9 kg (P<.001) in the Omega-3/Omega-3 group. In the placebo group, weight was unchanged at 6 months but had increased (P=.01) at 12 months follow-up after Omega-3 supplementation was initiated. Appetite improved in the Omega-3/Omega-3 group over the treatment period (P=.01). In logistic regression analyses, not carrying the APOEepsilon4 allele and high plasma DHA concentrations were independently related to weight gain in the combined group of patients at 6 months follow-up. CONCLUSION: A DHA-enriched Omega-3 FA supplement may positively affect weight and appetite in patients with mild to moderate AD. Not carrying the APOEepsilon4 allele and high DHA were independently associated with weight gain.
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Cole, Gregory M
1 September 2005 - 31 August 2009
NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE
Total Funding: $ 1,072,290
COLE, GREGORY M
1 September 2011 - 31 March 2016
NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE
Total Funding: $ 766,150
1 February 1989 - 30 June 2009
NATIONAL INSTITUTE ON AGING
Total Funding: $ 40,531,208
Inger Vedin; Tommy Cederholm; Yvonne Freund-Levi; Hans Basun; Anita Garlind; Gerd Faxén Irving; Maria Eriksdotter-Jönhagen; Lars-Olof Wahlund; Ingrid Dahlman; Jan PalmbladPloS one 2012;7(4):e35425.
Inger Vedin; Tommy Cederholm; Yvonne Freund Levi; Hans Basun; Anita Garlind; Gerd Faxén Irving; Maria Eriksdotter Jönhagen; Bengt Vessby; Lars-Olof Wahlund; Jan PalmbladThe American journal of clinical nutrition 2008;87(6):1616-22.
Yvonne Freund-Levi; Hans Basun; Tommy Cederholm; Gerd Faxén-Irving; Anita Garlind; Mikaela Grut; Inger Vedin; Jan Palmblad; Lars-Olof Wahlund; Maria Eriksdotter-JönhagenInternational journal of geriatric psychiatry 2008;23(2):161-9.
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