Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease.

J L Price; J C Morris (Profiled Author: Morris, John C)

Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Annals of neurology 1999;45(3):358-68.

The distribution and density of neurofibrillary tangles and amyloid plaques was studied in a unique series of cases whose premortem cognitive status had been assessed with the Clinical Dementia Rating (CDR), including 39 nondemented cases (CDR = 0; age, 51-88 years), 15 very mildly demented cases (CDR = 0.5), and 8 severely demented (CDR = 3) cases. The initial formation of tangles and plaques in healthy aging appeared to be independent of each other. Tangles were found in all the nondemented cases, especially in hippocampal and parahippocampal areas; the average tangle concentration increased exponentially with age. In contrast, plaques were absent in some brains up to age 88, and the earliest plaque formation in other cases occurred in the neocortex, in patches of diffuse plaques. Widely distributed neuritic as well as diffuse plaques throughout neocortex and limbic structures characterized a further group of nondemented cases. In these cases there was also a substantial increase over other nondemented cases, both in the number of tangles and in the rate of increase in tangles with age, suggesting an interaction between amyloid and neurofibrillary change at this stage. Such cases closely resemble CDR = 0.5 cases, and it is proposed they represent "preclinical" Alzheimer's disease.

2 Originating Grant

• 1.

  MORRIS, JOHN

  ALZHEIMERS DISEASE RESEARCH CENTER

  15 June 1997 - 30 April 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 29,005,627

• 2.

  MORRIS, JOHN

  HEALTHY AGING AND SENILE DEMENTIA

  1 January 1997 - 31 December 2013

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 30,196,104

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.