Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

In vivo reversal of amyloid-beta lesions in rat brain.

E M Sigurdsson; B Permanne; C Soto; T Wisniewski; B Frangione (Profiled Author: Frangione, Blas)

Department of Pathology, New York University Medical Center, New York 10016, USA.
Journal of neuropathology and experimental neurology 2000;59(1):11-7.

Cerebral amyloid-beta (Abeta) deposition is central to the neuropathological definition of Alzheimer disease (AD) with Abeta related toxicity being linked to its beta-sheet conformation and/or aggregation. We show that a beta-sheet breaker peptide (iAbeta5) dose-dependently and reproducibly induced in vivo disassembly of fibrillar amyloid deposits, with control peptides having no effect. The iAbeta5-induced disassembly prevented and/or reversed neuronal shrinkage caused by Abeta and reduced the extent of interleukin-1beta positive microglia-like cells that surround the Abeta deposits. These findings suggest that beta-sheet breakers, such as iAbeta5 or similar peptidomimetic compounds, may be useful for reducing the size and/or number of cerebral amyloid plaques in AD, and subsequently diminishing Abeta-related histopathology.

5 Originating Grant

• 1.

  Frangione, Blas

  AMYLOID ANGIOPATHY, EARLY PLAQUES & AGING

  1 January 1990 - 31 August 2006

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,063,685

• 2.

  Frangione, Blas

  Amyloidosis and Alzheimer's Disease

  1 July 1985 - 30 June 2007

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,467,436

• 3.

  FRANGIONE, BLAS

  AMYLOIDOSIS AND ALZHEIMERS DISEASE

  1 July 1985 - 30 June 1997

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 3,049,140

• 4.

  Frangione, Blas

  CONFORMATIONAL DISORDERS--AMYLOID AND PRION PROTEINS

  1 September 1978 - 31 March 2006

  NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

  Total Funding: $ 3,600,812

• 5.

  FRANGIONE, BLAS

  STRUCTURE OF IMMUNOGLOBULINS AND RELATED PROTEINS

  1 September 1978 - 31 March 1999

  NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

  Total Funding: $ 2,819,853

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.