Younkin, Steven G

Publication Detail

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Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.

N Ertekin-Taner; N Graff-Radford; L H Younkin; C Eckman; M Baker; J Adamson; J Ronald; J Blangero; M Hutton; S G Younkin (Profiled Authors: Younkin, Steven G; Hutton, Michael; Eckman, Christopher B)

Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.
Science (New York, N.Y.) 2000;290(5500):2303-4.

Plasma Abeta42 (amyloid beta42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Abeta42, we used plasma Abeta42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Abeta. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Abeta.

2 Originating Grant

• 1.

  PETERSEN, RONALD C

  Mayo Alzheimer's Disease Research Center

  1 May 1999 - 30 April 2014

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 25,743,859

• 2.

  YOUNKIN, STEVEN G

  ChAT, AChE, and Cholinergic Neurons in Aging and AD

  1 September 1997 - 31 May 2012

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 7,246,925

Scientific Context

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