Harvard University

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome.

E Head; B Y Azizeh; I T Lott; A J Tenner; C W Cotman; D H Cribbs (Profiled Author: Cotman, Carl W)

Institute for Brain Aging and Dementia, University of California, Irvine, California 92697-4540, USA.
Neurobiology of disease 2001;8(2):252-65.

To study the link between beta-amyloid (Abeta) and neuroinflammation, we examined the levels of complement as a function of age and extent of Abeta deposition in Down Syndrome (DS) brain. C1q, the first component of the complement cascade, was visualized using immunohistochemistry in the frontal, entorhinal cortex, and hippocampus of 12 DS ranging from 31 to 69 years of age. C1q was consistently associated with thioflavine-S positive Abeta plaques in DS brain and increased with more extensive age-dependent Abeta deposition. In contrast, little or no C1q labeling was associated with diffuse or thioflavine-S negative Abeta deposits. Neurons in the hippocampus and entorhinal cortex, but less frequently in frontal cortex, were C1q positive in DS cases with sufficient neuropathology to have a diagnosis of Alzheimer's disease. C1q-positive neurons were associated with activated microglia. These results provide evidence for Abeta-mediated inflammatory factors contributing to the rapid accumulation of neuropathology in DS brain.

2 Originating Grant

• 1.

  COTMAN, CARL WAYNE

  ADRC of the University of California, Irvine

  15 April 2000 - 31 March 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 19,671,992

• 2.

  COTMAN, CARL WAYNE

  Behavior and Neural Plasticity in the Aged

  1 August 1997 - 31 March 2013

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 30,822,252

Scientific Context

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