Seubert, Peter

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease.

Y Chu; E J Cochran; D A Bennett; E J Mufson; J H Kordower (Profiled Authors: Bennett, David A; Mufson, Elliott J)

Department of Neurological Sciences and Rush Alzheimer's Disease Center, Rush Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA.
The Journal of comparative neurology 2001;437(3):296-307.

Recent studies indicate that trkA expression is reduced in end-stage Alzheimer's disease (AD). However, understanding the neuropathologic correlates of early cognitive decline, as well as the changes that underlie the transition from nondemented mild cognitive impairment (MCI) to AD, are more critical neurobiological challenges. In these regards, the present study examined the expression of trkA mRNA in individuals diagnosed with MCI and AD from a cohort of people enrolled in a Religious Orders Study. Individuals with MCI and AD displayed significant reductions in trkA mRNA relative to aged-matched controls, indicating that alterations in trkA gene expression occur early in the disease process. The magnitude of change was similar in MCI and AD cases, suggesting that further loss of trkA mRNA is not necessarily associated with the transition of individuals from nondemented MCI to AD. The loss of trkA mRNA was not associated with education, apolipoprotein E allele status, gender, Braak score, global cognitive score or Mini-Mental Status Examination. In contrast, the loss of trkA mRNA in MCI and AD was significantly correlated with function on a variety of episodic memory tests.

4 Originating Grant

• 1.

  MUFSON, ELLIOTT JAY

  Neurobiology of Mild Cognitive Impairment in the Elderly

  1 September 1997 - 31 March 2013

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 20,516,366

• 2.

  BENNETT, DAVID ALAN

  Rush Alzheimer's Disease Core Center

  15 August 1997 - 30 June 2016

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 20,028,581

• 3.

  Trojanowski, John Q

  Molecular substrates of aging and neuron death

  15 May 1997 - 30 April 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 24,601,856

• 4.

  MIRRA, SUZANNE S

  EMORY ALZHEIMERS DISEASE CENTER

  30 September 1991 - 30 June 2001

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,700,782

Scientific Context

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