Pericak-Vance, Margaret A.

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Age at onset in two common neurodegenerative diseases is genetically controlled.

Yi-Ju Li; William K Scott; Dale J Hedges; Fengyu Zhang; P Craig Gaskell; Martha A Nance; Ray L Watts; Jean P Hubble; William C Koller; Rajesh Pahwa; et al. (Profiled Authors: Haines, Jonathan L; Roses, Allen D; Schmechel, Donald E; Saunders, Ann M; Small, Gary W; Pericak-Vance, Margaret A.; Gilbert, John R)

Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA.
American journal of human genetics 2002;70(4):985-93.

To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%--60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D10S1239 and D10S1237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.

7 Originating Grant

• 1.

  Schmechel, Donald E

  ALZHEIMER'S DISEASE RESEARCH CENTER

  1 May 2000 - 30 April 2005

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 16,537,307

• 2.

  Pericakvance, Margaret A

  Genetic Studies in Neurological Disorders

  1 March 1997 - 31 March 2009

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 18,660,474

• 3.

  Pericak-Vance, Margaret A

  GENOMIC SCREEN TO IDENTIFY ALZHEIMERS DISEASE GENES

  20 February 1997 - 31 January 2003

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 3,879,803

• 4.

  Small, Gary W

  FUNCTIONAL MRI FOR EARLY DIAGNOSIS OF ALZHEIMER'S

  10 August 1995 - 31 August 2006

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 3,111,865

• 5.

  SMALL, GARY W

  FUNCTIONAL BRAIN IMAGING AND MENTAL DISORDERS IN AGING

  1 July 1995 - 30 June 2001

  NATIONAL INSTITUTE OF MENTAL HEALTH

  Total Funding: $ 1,359,074

• 6.

  Cummings, Jeffrey L

  ALZHEIMERS DISEASE CENTER

  30 September 1991 - 31 March 1999

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 6,066,060

• 7.

  ROSES, ALLEN D

  ALZHEIMERS DISEASE RESEARCH CENTER

  30 September 1985 - 30 April 2000

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 17,660,528

Scientific Context

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