The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Expression of stromal cell-derived factor 1alpha protein in HIV encephalitis.
Dianne Langford; Virginia J Sanders; Margaret Mallory; Markus Kaul; Eliezer Masliah (Profiled Author: Masliah, Eliezer)
Department of Pathology, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA.
Journal of neuroimmunology 2002;127(1-2):115-26.
Analysis of the patterns of stromal cell-derived factor 1alpha (SDF-1alpha) expression in the brains from HIV-positive patients suggests that in neuronal cells, SDF-1alpha might play a role in neuroprotection and neurite extension in response to HIV infection. In all cases analyzed, SDF-1alpha immunoreactivity was primarily present in astroglial cells. Patients with HIV encephalitis (HIVE) showed intense somato-dendritic neuronal SDF-1alpha immunoreactivity, while HIVE negative patients with neurodegeneration had a significant decrease in neuronal SDF-1alpha immunoreactivity. Neuronal cells treated with SDF-1alpha displayed increased neurite outgrowth. Similarly, neurons treated with HIV-Tat, which induced SDF-1alpha expression, also showed neurite outgrowth. Tat-mediated neurite outgrowth was blocked by anti-SDF-1alpha antibody. These results suggest that SDF-1alpha may play a role in the neuronal response to HIV in the brains of AIDS patients.
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MAYEUX, RICHARD P
1 July 1989 - 30 June 1993
NATIONAL INSTITUTE OF MENTAL HEALTH
Total Funding: $ 1,060,315
1 May 2012 - 30 April 2017
NATIONAL INSTITUTE ON AGING
Total Funding: $ 387,292
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Norman J Haughey; Mark P MattsonJournal of acquired immune deficiency syndromes (1999) 2002;31 Suppl 2():S55-61.
Chava B Pocernich; Rukhsana Sultana; Eugene Hone; Jadwiga Turchan; Ralph N Martins; Vittorio Calabrese; Avindra Nath; D Allan ButterfieldJournal of neuroscience research 2004;77(4):532-9.
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