Iwatsubo, Takeshi

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Genetically engineered mouse models of neurodegenerative diseases.

Philip C Wong; Huaibin Cai; David R Borchelt; Donald L Price (Profiled Author: Price, Donald L)

Department of Pathology, The Johns Hopkins University School of Medicine, 558 Ross Research Building, 720 Rutland Avenue, Baltimore, Maryland 21205-2196, USA. wong@jhmi.edu
Nature neuroscience 2002;5(7):633-9.

Recent research has significantly advanced our understanding of the molecular mechanisms of neurodegenerative diseases, including Alzheimer's disease (AD) and motor neuron disease. Here we emphasize the use of genetically engineered mouse models that are instrumental for understanding why AD is a neuronal disease, and for validating attractive therapeutic targets. In motor neuron diseases, Cu/Zn superoxide dismutase and survival motor neuron mouse models are useful in testing disease mechanisms and therapeutic strategies for amyotrophic lateral sclerosis (ALS) and spinal motor atrophy, respectively, but the mechanisms that account for selective motor neuron loss remain uncertain. We anticipate that, in the future, therapies based on understanding disease mechanisms will be identified and tested in mouse model systems.

12 Originating Grant

• 1.

  Price, Donald L

  NEUROBIOLOGY OF DISEASE TRAINING PROGRAM

  1 July 1998 - 30 June 2004

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 1,021,630

• 2.

  Price, Donald L

  MECHANISMS OF MOTOR NEURON DISEASE

  15 January 1998 - 31 December 2001

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 1,629,618

• 3.

  ALBERT, MARILYN B

  Johns Hopkins Alzheimer's Disease Research Center

  15 July 1997 - 31 March 2015

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 5,559,946

• 4.

  Price, Donald L

  Alzheimer's Disease and Animal Models

  15 July 1997 - 31 March 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 44,095,695

• 5.

  PRICE, DONALD L

  PRESENILINS IN MODELS OF FAMILIAL ALZHEIMERS DISEASE

  12 March 1997 - 28 February 2002

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 2,001,677

• 6.

  Gandy, Samuel E

  Interdisciplinary Approach to Alzheimer Drug Discovery

  30 September 1991 - 31 August 2010

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 11,063,275

• 7.

  GREENGARD, PAUL

  INTERDISCIPLINARY APPROACH TO ALZHEIMER DRUG DISCOVERY

  30 September 1991 - 31 July 1996

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 2,198,300

• 8.

  PRICE, DONALD L

  MOLECULAR NEUROPATHOLOGY OF AGING AND DEMENTIA

  1 January 1989 - 31 December 1995

  NATIONAL INSTITUTE ON AGING

  Total Funding: $ 4,861,240

• 9.

  PRICE, DONALD L

  THE FOREBRAIN CHOLINERGIC SYSTEM IN HEALTH AND DISEASE

  1 April 1984 - 30 June 1992

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 4,029,351

• 10.

  PRICE, DONALD L

  DISORDERS OF AGING--TRANSMITTER SYSTEMS & NEUROTROPHINS

  1 April 1984 - 30 June 1997

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 10,370,755

• 11.

  PRICE, DONALD L

  MOTOR NEURON DISEASES AND TROPHIC THERAPIES

  1 March 1979 - 30 November 2001

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 5,158,019

• 12.

  Sisodia, Sangram S

  PRESENILINS IN MODELS OF FAMILIAL ALZHEIMERS DISEASE

  Total Funding: $ 1,966,810

Scientific Context

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