Perry, George

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Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?

George Perry; Akihiko Nunomura; Keisuke Hirai; Xiongwei Zhu; Mar Pérez; Jesús Avila; Rudolph J Castellani; Craig S Atwood; Gjumrakch Aliev; Lawrence M Sayre; et al. (Profiled Authors: Smith, Mark A; Zhu, Xiongwei; Avila, Jesús; Perry, George)

Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Free radical biology & medicine 2002;33(11):1475-9.

In less than a decade, beginning with the demonstration by Floyd, Stadtman, Markesbery et al. of increased reactive carbonyls in the brains of patients with Alzheimer's disease (AD), oxidative damage has been established as a feature of the disease. Here, we review the types of oxidative damage seen in AD, sites involved, possible origin, relationship to lesions, and compensatory changes, and we also consider other neurodegenerative diseases where oxidative stress has been implicated. Although much data remain to be collected, the broad spectrum of changes found in AD are only seen, albeit to a lesser extent, in normal aging with other neurodegenerative diseases showing distinct spectrums of change.

1 Originating Grant

• 1.

  Smith, Mark A

  METABOLIC ABNORMALITIES IN ALZHEIMER DISEASE

  1 May 1999 - 30 April 2006

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

  Total Funding: $ 750,386

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