The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA. email@example.com
Given the critical role of mitogen-activated protein kinase (MAPK) pathways in regulating cellular processes that are affected in Alzheimer's disease (AD), the importance of MAPKs in disease pathogenesis is being increasingly recognized. All MAPK pathways, i.e., the extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 pathways, are activated in vulnerable neurons in patients with AD suggesting that MAPK pathways are involved in the pathophysiology and pathogenesis of AD. Here we review recent findings implicating the MAPK pathways in AD and discuss the relationship between these pathways and the prominent pathological processes, i.e., tau phosphorylation and amyloid-beta deposition, as well as the functional association to amyloid beta protein precursor. We suggest that regulation of these pathways may be a central facet to any potential treatment for the disease.
1 Originating Grant
Smith, Mark A
1 May 1999 - 30 April 2006
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Total Funding: $ 750,386
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
2 September 2011 - 30 June 2014
FOGARTY INTERNATIONAL CENTER
Total Funding: $ 70,352
HYMAN, BRADLEY T
15 April 2011 - 31 March 2016
NATIONAL INSTITUTE ON AGING
Total Funding: $ 868,259
GANDY, SAMUEL E
20 September 1992 - 31 July 1995
NATIONAL INSTITUTE ON AGING
Total Funding: $ 544,235
C Atzori; B Ghetti; R Piva; A N Srinivasan; P Zolo; M B Delisle; S S Mirra; A MigheliJournal of neuropathology and experimental neurology 2001;60(12):1190-7.
Xiongwei Zhu; Arun K Raina; Hyoung-Gon Lee; Mark Chao; Akihiko Nunomura; Massimo Tabaton; Robert B Petersen; George Perry; Mark A SmithAntioxidants & redox signaling 2003;5(5):571-6.
A Mudher; S Chapman; J Richardson; A Asuni; G Gibb; C Pollard; R Killick; T Iqbal; L Raymond; I Varndell; et al.The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(14):4987-95.
Appears in this Publication
Author of this Publication