The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Derivatives of xanthic acid are novel antioxidants: application to synaptosomes.
Christopher M Lauderback; Jennifer Drake; Daohong Zhou; Janna M Hackett; Alessandra Castegna; Jaroslaw Kanski; Maria Tsoras; Sridhar Varadarajan; D Allan Butterfield (Profiled Author: Butterfield, D Allan)
Department of Chemistry and Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506, USA.
Free radical research 2003;37(4):355-65.
Xanthic acids have long been known to act as reducing agents. Recently, D609, a tricyclodecanol derivative of xanthic acid, has been reported to have anti-apoptotic and anti-inflammatory properties that are attributed to specific inhibition of phosphatidyl choline phospholipase C (PC-PLC). However, because oxidative stress is involved in both of these cellular responses, the possibility that xanthates may act as antioxidants was investigated in the current study. Finding that xanthates efficiently scavenge hydroxyl radicals, the mechanism by which D609 and other xanthate derivatives may protect against oxidative damage was further examined. The xanthates studied, especially D609, mimic glutathione (GSH). Xanthates scavenge hydroxyl radicals and hydrogen peroxide, form disulfide bonds (dixanthogens), and react with electrophilic products of lipid oxidation (acrolein) in a manner similar to GSH. Further, upon disulfide formation, dixanthogens are reduced by glutathione reductase to a redox active xanthate. Supporting its role as an antioxidant, D609 significantly (p < 0.01) reduces free radical-induced changes in synaptosomal lipid peroxidation (TBARs), protein oxidation (protein carbonyls), and protein conformation. Thus, in addition to inhibitory effects on PC-PLC, D609 may prevent cellular apoptotic and inflammatory cascades by acting as antioxidants and novel GSH mimics. These results are discussed with reference to potential therapeutic application of D609 in oxidative stress conditions.
1 Originating Grant
Markesbery, William R
15 May 1997 - 31 March 2013
NATIONAL INSTITUTE ON AGING
Total Funding: $ 17,393,197
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2 September 2011 - 30 June 2014
FOGARTY INTERNATIONAL CENTER
Total Funding: $ 70,352
Gururaj Joshi; Rukhsana Sultana; Marzia Perluigi; D Allan ButterfieldFree radical biology & medicine 2005;38(8):1023-31.
M Perluigi; G Joshi; R Sultana; V Calabrese; C De Marco; R Coccia; D A ButterfieldNeuroscience 2006;138(4):1161-70.
Mubeen Ahmad Ansari; Gururaj Joshi; Quanzhen Huang; Wycliffe O Opii; Hafiz Mohmmad Abdul; Rukhsana Sultana; D Allan Butterfield
In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidative stress-related neurodegenerative disorders.Free radical biology & medicine 2006;41(11):1694-703.
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